Rab11 antibody
- Known as:
- Rab11 (anti-)
- Catalog number:
- orb100719
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- Rab11 antibody
Related genes to: Rab11 antibody
- Gene:
- RAB11FIP1 NIH gene
- Name:
- RAB11 family interacting protein 1
- Previous symbol:
- -
- Synonyms:
- RCP, FLJ22622, FLJ22524, Rab11-FIP1
- Chromosome:
- 8p11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-22
- Date modifiied:
- 2016-10-05
- Gene:
- RAB11FIP2 NIH gene
- Name:
- RAB11 family interacting protein 2
- Previous symbol:
- -
- Synonyms:
- KIAA0941, nRip11, Rab11-FIP2
- Chromosome:
- 10q26.11
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-22
- Date modifiied:
- 2016-10-05
- Gene:
- RAB11FIP3 NIH gene
- Name:
- RAB11 family interacting protein 3
- Previous symbol:
- -
- Synonyms:
- KIAA0665, Rab11-FIP3, eferin
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-22
- Date modifiied:
- 2016-04-29
Related products to: Rab11 antibody
Related articles to: Rab11 antibody
- Rab11-family interacting proteins (Rab11‑FIPs) are associated with the progression of various tumors; however, their expression and clinical significance in colorectal cancer (CRC) remains largely undetermined. In this study, the clinical implications, functions and underlying mechanisms of Rab11‑FIP4 in CRC were investigated. Immunohistochemical analysis revealed that expression of Rab11‑FIP4 was significantly increased in human CRC tissues and correlated with poor prognosis of patients with CRC. Overexpression of Rab11‑FIP4 in the CRC cell line significantly promoted cell proliferation, migration and invasion in vitro and tumor metastasis in vivo. Furthermore, the results of a co‑immunoprecipitation assay and western blot analysis demonstrated that Rab11‑FIP4 interacted with Rab11 and insulin‑like growth factor 1 receptor, and increased the phosphorylation of extracellular signal‑regulated kinase 1/2 and AKT serine/threonine kinase. In addition, hypoxia contributed to the upregulation of Rab11‑FIP4 expression via hypoxia‑inducible factor‑1α activation of the Rab11‑FIP4 promoter. In conclusion, the results of the present study suggest that Rab11‑FIP4 may act as an oncogene in CRC, and may be a potential therapeutic target for the treatment of patients with CRC. - Source: PubMed
Publication date: 2017/12/15
Wang Jian-ZhangYang Shou-XingYe FangpengXia Xuan-PingShao Xiao-XiaoXia Sheng-LongZheng BoXu Chang-Long - Rab11a is a small GTP-binding protein enriched in the pericentriolar plasma membrane recycling systems. We hypothesized that Rab11a-binding proteins exist as downstream effectors of its action. Here we define a family of four Rab11-interacting proteins: Rab11-Family Interacting Protein 1 (Rab11-FIP1), Rab11-Family Interacting Protein 2 (Rab11-FIP2), Rab11-Family Interacting Protein 3 (Rab11-FIP3), and pp75/Rip11. All four interacting proteins associated with wild type Rab11a and dominant active Rab11a (Rab11aS20V) as well as Rab11b and Rab25. Rab11-FIP2 also interacted with dominant negative Rab11a (Rab11aS25N) and the tail of myosin Vb. The binding of Rab11-FIP1, Rab11-FIP2, and Rab11-FIP3 to Rab11a was dependent upon a conserved carboxyl-terminal amphipathic alpha-helix. Rab11-FIP1, Rab11-FIP2, and pp75/Rip11 colocalized with Rab11a in plasma membrane recycling systems in both non-polarized HeLa cells and polarized Madin-Darby canine kidney cells. GFP-Rab11-FIP3 also colocalized with Rab11a in HeLa cells. Rab11-FIP1, Rab11-FIP2, and pp75/Rip11 also coenriched with Rab11a and H(+)K(+)-ATPase on parietal cell tubulovesicles, and Rab11-FIP1 and Rab11-FIP2 translocated with Rab11a and the H(+)K(+)-ATPase upon stimulating parietal cells with histamine. The results suggest that the function of Rab11a in plasma membrane recycling systems is dependent upon a compendium of protein effectors. - Source: PubMed
Publication date: 2001/08/08
Hales C MGriner RHobdy-Henderson K CDorn M CHardy DKumar RNavarre JChan E KLapierre L AGoldenring J R