Prkg1 antibody
- Known as:
- Prkg1 (anti-)
- Catalog number:
- orb101133
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- Prkg1 antibody
Related genes to: Prkg1 antibody
- Gene:
- PRKG1 NIH gene
- Name:
- protein kinase cGMP-dependent 1
- Previous symbol:
- PRKGR1B, PRKG1B
- Synonyms:
- PGK, PKG, PKG1
- Chromosome:
- 10q11.23-q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-17
- Date modifiied:
- 2019-04-23
Related products to: Prkg1 antibody
Related articles to: Prkg1 antibody
- Cetaceans face the risk of thromboembolism due to diving and decompression responses. However, cetaceans maintain normal blood circulation. This study explores the molecular mechanisms cetaceans use to mitigate diving-associated hemostatic challenges during diving. Forty-six species were analyzed, including 18 cetaceans, 9 artiodactyls, and 19 other terrestrial mammals. Thirty-nine anticoagulant genes and proteins were examined, identifying 6 genes (ANXA2, ANXA5, FGA, FGB, PLAUR, and PLG) with conserved evolution, 4 genes (ANXA2, PDGFB, SH2B3, THBS1) with positive selection, and 12 proteins (APOH, FGA, FGB, FGG, GP1BA, PLAU, PRKCD, PRKG1, SERPINF2, SERPING1, TMPRSS6, and TMX1) with specific amino acid sites in cetaceans. Ancestral state reconstruction revealed independent evolution of deep diving behavior in different cetacean lineages, particularly within Odontoceti. Correlation analysis linked the evolution of the APOE gene with diving depth, suggesting its role in diving adaptation. These analyses suggest that cetaceans may help reduce the risk of thrombosis during diving by lowering platelet activity, enhancing fibrinolysis, and modulating the coagulation cascade. These analyses suggest that cetaceans may mitigate diving-associated thrombotic risk by modulating platelet activity, fibrinolysis, and the coagulation cascade. Overall, this study identifies candidate anticoagulant-related genes and amino acid substitutions for future functional validation of hemostatic adaptation in cetaceans. - Source: PubMed
Publication date: 2026/07/06
Lv WenjunCao LiZhang YaXu ShixiaRen Wenhua - Metabolic dysfunction-associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α-smooth muscle actin-positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO-cGMP signalling axis. Modulating this pathway could alter HSC activation and fibrosis during MASH progression. - Source: PubMed
Publication date: 2026/06/25
Rajeeth KrithikaRoessing MalteLehners MoritzDietz LisaSchmitt AnjaHailfinger StephanPeter AndreasQuintanilla-Martinez LeticiaGonzalez-Menendez IreneMederacke IngmarOtt GermanSandner PeterSchwab MatthiasFeil RobertFeil Susanne - Lumbar disc degeneration (LDD) is a common spinal disorder that predisposes patients to lumbar disc herniation (LDH) and causes chronic low back pain. Its pathogenesis remains incompletely understood. This study investigated the clinical relevance of PRKG1-AS1 in LDD and explored its regulation of LDD progression through miR-218-5p, providing experimental support for LDD targeted treatment. - Source: PubMed
Publication date: 2026/06/01
Xu JianqiaoMa ZiyueWang LiLu ZichengWang TianhaoLiu JianhengZhao YingfeiZhu XiaohuXi Bo - Sepsis-induced acute lung injury (ALI) is a life-threatening condition associated with high mortality, yet the molecular mechanisms driving alveolar damage remain incompletely understood. Long non-coding RNA (lncRNA) TUG1 has been implicated in organ injury, but its specific role and regulatory network in septic ALI have not been fully elucidated.Using lipopolysaccharide (LPS)-treated mouse lung epithelial (MLE-12) cells and a murine model of ALI, we investigated the functional role of TUG1 through overexpression strategies. Gene expression, protein levels, inflammatory cytokines, and miRNA interactions were assessed via qPCR, Western blotting, ELISA, and dual-luciferase reporter assays. Bioinformatic analysis of public datasets (GSE241238, GSE48080) was performed to validate clinical relevance.TUG1 expression was significantly downregulated in LPS-induced ALI models. TUG1 overexpression mitigated inflammation and oxidative stress by acting as a competing endogenous RNA (ceRNA) for miR-222-3p, thereby derepressing CALM1. Activation of CALM1 subsequently engaged the PRKG1/RYR3 signaling cascade, leading to restoration of AQP5-mediated alveolar fluid clearance. Analysis of public datasets confirmed suppression of the TUG1/CALM1 axis in septic patients and revealed its association with adverse survival outcomes. While the preliminary sample sizes (n = 3 in vitro, n = 5 in vivo) limit the statistical power (post-hoc 0.65), the robust trends support the TUG1 axis as a potential target, though larger cohort validation is needed.This study identifies TUG1 as a potential modulator of sepsis-induced ALI through the miR-222-3p/CALM1/PRKG1/RYR3/AQP5 axis. These findings underscore the therapeutic potential of targeting TUG1 to alleviate septic lung injury. These findings identify TUG1 as a protective lncRNA that acts via the miR-222-3p/CALM1 axis to regulate calcium signaling and alveolar fluid clearance. Targeting this pathway may offer a novel therapeutic strategy for sepsis-induced ALI. - Source: PubMed
Publication date: 2026/05/16
Li ZheChen WanShi LeiQiu GuozhengZhou YaoWei YanlinHuang ZhengzhuangLyu Liwen - The swamp eel (), known for its benthic and nocturnal feeding habits, exhibits a keen sense of smell. To date, the genomic basis for its adaptive evolution of olfactory system was poorly investigated. In this study, we performed comparative genomic analysis to reveal the evolutionary processes underlying the expansion and diversification of olfactory receptor (OR) genes in the swamp eel. A total of 629 gene families were identified to expand in the swamp eel, with five (, , , , and ) distributed in olfactory transduction (KEGG map04740). GO enrichment analysis of these expanded gene families showed biological processes related to sensory perception of smell and detection of chemical stimulus. Among the 287 positively selected genes (PSGs) in the swamp eel, , , , , , , and were linked to signal transduction. A total of 318 OR genes (289 functional genes, 10 partial genes, and 19 pseudogenes) were annotated in the swamp eel genome, significantly surpassing other fish species. Clusters of OR genes were detected on chromosome 4, chromosome 8, chromosome 9, and chromosome 12 in the swamp eel, sharing the same transcriptional orientation, which indicated that tandem duplication was a possible mechanism for the OR gene expansion. Phylogenetic analysis revealed the obvious expansion pattern of OR genes in groups δ and ζ for the swamp eel. Conserved motifs were detected in the OR genes, which indicated the similar functions of OR genes. Our findings unveiled the genomic basis for the olfactory evolution in the swamp eel, providing insights for a better understanding of swamp eel's environmental adaptation and contributing to further investigation of olfactory function in fish. This study enriches the genomic research on the olfactory system of benthic nocturnal fishes and provides a useful evolutionary case for understanding olfactory adaptation to ecological niches in fish. - Source: PubMed
Publication date: 2026/04/29
Zhou ChuangWang ZhongyiZhang ChenhaoSong Zhaobin