Plastin L antibody
- Known as:
- Plastin L (anti-)
- Catalog number:
- orb101143
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- Plastin antibody
Related genes to: Plastin L antibody
- Gene:
- PLS1 NIH gene
- Name:
- plastin 1
- Previous symbol:
- -
- Synonyms:
- I-plastin, Plastin-1
- Chromosome:
- 3q23
- Locus Type:
- gene with protein product
- Date approved:
- 1997-08-18
- Date modifiied:
- 2015-03-03
Related products to: Plastin L antibody
Related articles to: Plastin L antibody
- The antioxidant activity of natural and semi-synthetic depsides and benzofurans-including -(+)-usnic acid (), dibenzoyl usnic acid (), atranorin (), 2,4-bis(benzoyloxy)atranorin (), 4--methyl atranorin (), decarboxythamnolic acid (), thamnolic acid (), and perlatolic acid ()-was evaluated in this study. Natural compounds were isolated from selected lichen species, whilst semi-synthetic derivatives were prepared to investigate the influence of esterification and methylation on electronic properties and radical-scavenging capacity. Structural elucidation was performed using NMR spectroscopy and mass spectrometry (MS). Electronic and thermodynamic descriptors, including the bond dissociation energy (BDE) of the most reactive O-H group, HOMO and LUMO energies, the HOMO-HOMO-1 energy gap (ΔH(H-1)), polarisability, and logP, were calculated and correlated with experimentally determined antioxidant capacity using the TEAC assay. Multivariate partial least squares (PLS-1) analysis identified ΔH(H-1) and LUMO as the primary determinants of antioxidant activity, with BDE and ΔHf providing complementary contributions. Perlatolic acid () exhibited the highest radical-scavenging capacity (TEAC = 2.7), whereas -(+)-usnic acid () and dibenzoyl usnic acid () were the least active compounds (TEAC ≈ 0.1). Antioxidant activity was found not to correlate with the number of hydroxyl groups, but rather to be governed by electronic redistribution, conjugation effects, and substituent modulation. Exclusion of the outlier decarboxythamnolic acid () improved model performance, explaining 79.8% of the variance in TEAC values (RY), with strong predictive ability (Q = 0.724) using a single latent variable. Overall, these findings provide a robust basis for the prediction and rational design of new antioxidant compounds, highlighting the relevance of lichen-derived metabolites as structurally stable scaffolds with potential applications in pharmaceutical and nutraceutical development. - Source: PubMed
Publication date: 2026/05/05
Mollinedo PatriciaVila José LuisNogales-Ascarrunz PaolaApaza Ticona Luis - Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition with widespread brain structure alterations. However, the relationship between macroscale cortical organization and microscale molecular mechanisms remains unclear, particularly regarding the neurobiological mechanisms shared between the full ADHD cohort and its combined subtype (ADHD-C). - Source: PubMed
Publication date: 2026/05/11
Zeng YexianYang LiCui ZaixuCao Qingjiu - Neuroticism is significantly associated with various psychiatric disorders. Individuals exhibiting high levels of neuroticism are more susceptible to experiencing anxiety, depression, and other negative emotional responses. Research on the differences in macroscopic functional connectivity gradients among neuroticism levels and their associations with microscopic transcriptomics remains scarce. This study explores the associations between functional gradient and transcriptional expression in neuroticism across 109 individuals with low neuroticism (LNG) and 210 with medium-high neuroticism (MHNG). We analyzed functional gradient alterations in MHNG and their correlations with neurotransmitters, meta-analytic cognitive terms, and transcriptional patterns using partial least squares regression (PLS), involving similarity with major psychiatric disorders, functional enrichments, developmental stages, cortical layers, and specific cell types. MHNG exhibited functional gradient changes within the default, limbic, and visual networks, which correlated with higher-order cognitive terms and alterations in several neurotransmitters. We identified significant overlaps between PLS1 weighted genes and those dysregulated in schizophrenia and autism. Genes linked with gradient alterations were enriched in synaptic signaling, infection and metabolism, astrocytes, specific cortical layers, and developmental phases from early fetal to young adulthood. These findings offer a critical theoretical foundation for understanding the complex relationship between macroscopic functional gradients and microscopic transcriptional patterns across various neuroticism levels. - Source: PubMed
Li JingLi XinrongLi RuitingLuo JingXu YongYao Guanqun - Melancholic depression has more severe clinical manifestations, and its mechanism remains unclear. The deficit of reward network (RN) has been reported to be strongly related to anhedonia of melancholic depression. The triple network, including the default-mode network (DMN), executive control network (ECN), and salience network (SN), was found to exhibit abnormal functional coupling across many mental processes. Whether activities of the RN and its connectivity with the triple network could affect emotional symptoms in melancholic depression is worth exploring. - Source: PubMed
Publication date: 2026/05/04
Yan MeiqiChen ZhaobinLi HuabingHu MuliLiu FengXie GuangrongGuo WenbinCui XilongOu Yangpan - Accurate localization of epileptic activity remains challenging when interictal discharges are absent or sparse. Although resting-state functional MRI (rs-fMRI) is noninvasive, individual rs-fMRI metrics provide inconsistent and incomplete localization. We aimed to determine whether multivariate integration of rs-fMRI features could robustly identify syndrome-specific epileptic activity in childhood epilepsy. - Source: PubMed
Publication date: 2026/05/06
Zhang QiruiZhang ZixuanLi YvzhuoHe YanYang FangKim JacquelineTracy Joseph ILu GuangmingZhang Zhiqiang