TUSC5 antibody
- Known as:
- TUSC5 (anti-)
- Catalog number:
- orb101290
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- TUSC5 antibody
Related genes to: TUSC5 antibody
- Gene:
- TRARG1 NIH gene
- Name:
- trafficking regulator of GLUT4 (SLC2A4) 1
- Previous symbol:
- TUSC5
- Synonyms:
- LOST1, IFITMD3, BEC-1, DSPB1
- Chromosome:
- 17p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-24
- Date modifiied:
- 2018-03-22
Related products to: TUSC5 antibody
Related articles to: TUSC5 antibody
- To investigate the molecular mechanisms underlying muscle fiber development in different pig breeds and their impact on meat quality, this study collected the longissimus dorsi muscle of the indigenous Huainan pig and the commercial Large White pig at four developmental stages (0, 7, 14, and 21 days postnatal). Muscle fiber types were identified using myosin ATPase staining, while transcriptomics and non-targeted metabolomics were employed to analyze differences in gene expression and metabolite composition. The results showed that the Huainan pig had a higher proportion of oxidative muscle fibers, indicating superior aerobic metabolic capacity and meat quality. Transcriptome data identified 18 differentially expressed genes common to both pig breeds, including , , , and , which were upregulated in Huainan pigs to regulate muscle fiber type composition and meat quality by influencing mitochondrial function, nitric oxide synthesis, and glucose/lipid metabolism. Metabolomics analysis revealed significantly elevated levels of carnosine, citrulline, serine, and glycerol-3-phosphate in Huainan pigs, which are associated with metabolic pathways promoting muscle fiber transformation via enhancing energy supply, antioxidant capacity, and fatty acid oxidation. Notably, integrated transcriptome-metabolome analysis showed that oxidative metabolism genes (e.g., ) and metabolites (e.g., citrulline) formed an AMPK-mediated 'gene-metabolite' loop in Huainan pigs, which synergistically promotes mitochondrial function and fiber differentiation. In summary, this study provides new insights into the molecular mechanisms underlying meat quality differences between pig breeds and offers a theoretical basis for the breeding and development of high-quality pork. - Source: PubMed
Publication date: 2025/10/14
Wang JingJia MingyangZhang HanbingGuo YapingZhang QiYan XiangzhouLu QingxiaZhang SihuanXing Baosong - Intestinal malrotation is a congenital malformation of the embryonic gut that may cause midgut volvulus either in children or adults. Our understanding of its genetic background stems from reports of syndromic or familial forms and no genome-wide association studies (GWAS) have been reported. We perform the first GWAS to identify common variants associated with this malformation. - Source: PubMed
Publication date: 2025/04/08
Gaitanidis ApostolosChristensen Mathias ADorken Gallastegi AnderBreen Kerry AVelmahos George CKaafarani Haytham M AFarhat Maha R - Parental living environment significantly impacts on offspring, yet related studies are lacking in livestock and poultry production. The present study found that lipopolysaccharide (LPS, Escherichia coli, 0.2 mg/kg) stimulation in F0 hens led to growth retardation and a decrease in egg-laying rate in the unchallenged F1 hens. Using strand-specific transcriptomic data of peripheral blood mononuclear cells (PBMCs) in F1 hens, we identified 100 differentially expressed lncRNAs (DELs) and 452 differentially expressed genes (DEGs). LPS primarily affected the metabolic pathways of the offspring, possibly reducing the egg-laying rate of the F1 hens by inhibiting the ferroptosis signaling pathway and the expression of DEGs involved, such as NCOA4, SLC40A1, STEAP3, and TFRC. Using Pearson correlation analysis, we constructed a lncRNA-mRNA-egg-laying rate regulation network and found that the newly identified lncRNA MSTRG.6500.1 and its positively regulated target genes (ENSGALT00000051184, ENSGALT00000053276, NPPA, OSBP2, and TRARG1) were significantly downregulated in the F1 LPS group, which might be the main reason for the decrease in egg-laying rate of the LPS group. These results provide important references for the study of growth and reproductive performance in laying hens, revealing the impact of parental living environment on animal health and production performance, and providing a theoretical basis for future related research and breeding practices. - Source: PubMed
Publication date: 2024/11/30
Liu LeiWang WeiAdetula Adeyinka AbiolaYan ZhixunLiu HuaguiYu YingChu Qin - The intramuscular oleic-to-stearic fatty acid ratio (C18:1n-9/C18:0) is an important indicator of the biosynthesis and desaturation of fatty acids in muscle. By using an RNA-Seq approach in muscle samples from 32 BC1_DU (25% Iberian and 75% Duroc) pigs with divergent values (high: H and low: L) of C18:1n-9/C18:0 fatty acids ratio, a total of 81 differentially expressed genes (DEGs) were identified. Functional analyses of DEGs indicate that mainly peroxisome proliferator-activated receptor signaling pathway (associated genes: PPARG, SCD, PLIN1, and FABP3) was overrepresented. Notably, SCD is directly involved in the conversion of C18:0 to C18:1n-9, and PPARG is a transcription factor regulating lipid metabolism genes, including SCD. However, other DEGs (e.g., ACADVL, FADS3, EPHB2, HGFAC, NGFR, NR0B2, MDH1, MMAA, PPP1R1B, SFRP5, RAB30, and TRARG1) are plausible candidate genes to explain the phenotypic differences of the C18:1n-9/C18:0 ratio. Interestingly, seven genetic variants within the SCD (including the well-known AY487830:g.2228T>C SNP and other novel genotyped polymorphisms) are associated with two haplotypes. Although the haplotypes are segregating at different frequencies in the H and L groups, they do not fully explain the desaturation ratios or the SCD expression levels. A more complex model, including polyunsaturated fatty acids such as C18:2n-6, C20:4n-6, and C18:3n-3, is suggested to explain the regulation of the C18:1n-9/C18:0 desaturation ratio in porcine muscle. - Source: PubMed
Publication date: 2024/11/26
Valdés-Hernández JesúsRamayo-Caldas YuliaxisPassols MagíCriado-Mesas LourdesCastelló AnnaSánchez ArmandFolch Josep M - The dispanins are a family of 15 transmembrane proteins that have diverse and often unclear physiological functions. Many dispanins, including synapse differentiation induced gene 1 (SynDIG1), proline-rich transmembrane protein 1 (PRRT1)/SynDIG4, and PRRT2, are expressed in the central nervous system (CNS), where they are involved in the development of synapses, regulation of neurotransmitter release, and interactions with ion channels, including AMPA receptors (AMPARs). Others, including transmembrane protein 233 (TMEM233) and trafficking regulator of GLUT4-1 (TRARG1), are expressed in the peripheral nervous system (PNS); however, the function of these dispanins is less clear. Recently, a family of neurotoxins isolated from the giant Australian stinging tree was shown to target TMEM233 to modulate the function of voltage-gated sodium (Na) channels, suggesting that the dispanins are inherently druggable. Here, we review current knowledge about the structure and function of the dispanins, in particular TMEM233 and its two most closely related homologs PRRT2 and TRARG1, which may be drug targets involved in neurological disease. - Source: PubMed
Publication date: 2024/07/17
Deuis Jennifer RKlasfauseweh TabeaWalker LucindaVetter Irina