MAG1 antibody
- Known as:
- MAG1 (anti-)
- Catalog number:
- orb101508
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- MAG1 antibody
Related genes to: MAG1 antibody
- Gene:
- GPAT3 NIH gene
- Name:
- glycerol-3-phosphate acyltransferase 3
- Previous symbol:
- AGPAT9
- Synonyms:
- MGC11324, LPAAT-theta, MAG1, HMFN0839, AGPAT10
- Chromosome:
- 4q21.23
- Locus Type:
- gene with protein product
- Date approved:
- 2008-01-29
- Date modifiied:
- 2015-08-03
Related products to: MAG1 antibody
Related articles to: MAG1 antibody
- This study elucidates the biochemical mechanisms by which extreme high-altitude environments are associated with the remodeling of the skeletal muscle flavor profile in sheep. Using Bayinbuluke (high-altitude) and Turpan Black (low-altitude) sheep, we integrated volatilomics, metabolomics, transcriptomics, and proteomics to map flavor precursor networks. Odor activity value analysis revealed that high-altitude meat exhibited sub-threshold suppression of animal off-flavors, such as p-cresol, while significantly amplifying premium fruity esters. Targeted metabolomics attributed this sensory inversion to a structural shift in the precursor pool, specifically the enrichment of highly reactive polyunsaturated fatty acids, L-cysteine, and rhamnose. Multi-omics integration demonstrated that cold and hypoxic stresses are associated with metabolic reprogramming. The synergistic downregulation of the gene and APOC3 protein was associated with redirected lipid flux, suggesting a mechanism for functional fatty acid accumulation. Simultaneously, the pronounced upregulation of the gene, potentially driven by antioxidant defense needs, coincided with substantial L-cysteine accumulation. Correlation networks suggested that this precursor shift is negatively correlated with off-flavor generation, possibly via competitive thermal degradation. In conclusion, extreme ecological stress is associated with convergent metabolic reprogramming, contributing to the reconstruction of the flavor precursor pool to alter the characteristic lipid aroma of plateau meat. While these findings provide a comprehensive structural blueprint of plateau meat characteristics, the proposed mechanisms remain hypothetical and warrant future functional and sensory validation. - Source: PubMed
Publication date: 2026/07/16
Yang YalingLiu WujunCao Hang - Fat accumulation and tetrodotoxin (TTX) resistance are critical adaptive traits that enable pufferfish to cope with migratory behavior and environmental fluctuations. Here, we integrate whole-genome sequencing, transcriptomic, and electrophysiological analyses to investigate the molecular mechanisms underlying fatty acid metabolism and TTX tolerance in Takifugu fasciatus. A high-quality genome assembly (372.8 Mb, with 94.9% of sequences anchored to 22 chromosomes) suggests that the ancestral freshwater population of T. fasciatus adapted to marine environments approximately 130,000 years ago. DGAT2 and GPAT3 are identified as key regulators of lipid biosynthesis. RNA interference (RNAi)-mediated silencing of these genes significantly reduces hepatic triglyceride levels and lipid droplet accumulation. Four amino acid substitutions are found in Na1.4 channels of T. fasciatus, with a D400E mutation in Domain I that significantly enhancing TTX resistance. These findings highlight conserved lipid metabolism pathways and Na channel mutations as key evolutionary strategies for environmental adaptation in pufferfish. - Source: PubMed
Publication date: 2026/07/16
Zang XuechunWang TaoShang RuhuaYin DanqingBi YihuiChu PengZhao ChengLiu YuxiZou ShanmeiYin Shaowu - Metabolic syndrome (MetS) has been associated with increased acute pancreatitis (AP) severity. This study aimed to identify shared differentially expressed genes (CDEGs) between MetS and AP and to prioritize mechanistically relevant targets. The shared genetic basis and causal effect of MetS on AP were first assessed using linkage disequilibrium score regression (LDSC) and two-sample Mendelian randomization (MR). Public Gene Expression Omnibus (GEO) datasets were analyzed to define shared CDEGs. A multi-step pipeline incorporating functional enrichment, protein-protein interaction (PPI) analysis, and transcription factor mapping was used to identify AP hub genes (AP-HGs). Functional relatedness and putative causal relationships were evaluated using GeneMANIA, MR, and single-cell RNA sequencing (scRNA-seq). Finally, computational drug prediction and molecular docking were performed to identify potential therapeutic agents. Key findings were further validated in a hyperlipidemia AP (HAP) model. A positive genetic correlation between MetS and AP was identified by LDSC, and MR supported a causal effect of MetS on increased AP risk. BCAT1, GPAT3, ANP32C, and ZNF683 were identified as CDEGs between MetS and AP. MAPK14 was identified as a central AP-HG. MAPK14, BCAT1, and GPAT3 were effective predictors for severe AP (SAP), with AUCs of 0.738, 0.722, and 0.744, respectively. GeneMANIA predicted a high degree of physical interaction (77.6%) among these genes. MR analysis provided supportive genetic evidence linking MAPK14 expression to inflammatory mediators including IL-1ra and TNFR-1. scRNA-seq analysis in an experimental AP model localized Mapk14 expression predominantly to macrophages, while Bcat1 marked a unique, proliferative fibroblast subpopulation that emerged transiently during inflammation and exhibited an anabolic metabolic signature. Ozagrel was prioritized as an exploratory candidate with favorable predicted binding affinities and requires further validation. In a HAP model, aggravated pancreatic injury and upregulation of BCAT1 and MAPK14 were confirmed under the high-fat background. A genetic and transcriptomic link between MetS and AP was identified. MAPK14-associated inflammation and Bcat1-positive fibroblast remodeling may contribute to AP aggravation under metabolic disturbance. These findings provide candidate biomarkers for SAP prediction and support BCAT1 and MAPK14 as potential mechanistic targets. - Source: PubMed
Zhou XiaoyingYang ChenZou TongxinBasharat ZarrinZippi MaddalenaFiorino SirioHong Wandong - The improvement of meat quality by selenium (Se) supplementation has been well documented; however, the effects and underlying mechanisms by which Se-enriched yeast modulates meat quality remain unclear. This study aimed to investigate the effects of Se-enriched yeast on meat quality and its molecular characteristics in finishing pigs. All pigs were fed a Se-deficient diet (SeD) or the same diet supplemented with 0.3, 1, 3, or 5 mg Se/kg (CT, SY1, SY3, and SY5). - Source: PubMed
Publication date: 2026/07/05
Qiu XiangqiLu PanpanXiao MingfeiZeng SumeiLi LiYu HaitaoDeng AihuaZhu MinXu EZeng Xiangfang - High-latitude populations represent valuable case studies to investigate the genetic bases of human biological adaptations to cold climates. Nevertheless, by relying on traditional natural selection models, a limited fraction of them was identified. To overcome this issue, we integrate diverse inferential methods in the attempt to pinpoint combinations of genes presenting both selection signatures and functional relationships supporting their synergic role in regulating a biological trait, as expected under polygenic adaptation. We analyze Yakut genomes from Northeastern Siberia and Russian ones, pointing to adaptive evolution at genes contributing to functions modulated during cold exposure, such as thyroid hormone/insulin signalling (THRB, RCAN2, INSR, NFKB1), brown adipose tissue differentiation (ERBB4) and glycerolipid metabolism (GPAT3). Concerted changes at these loci may support enhanced heat production and responsiveness to insulin, having been partly influenced also by Neanderthal introgression, and provide suggestive insights into the complex adaptations that enabled Eurasians' ancestors to colonize cold environments. - Source: PubMed
Publication date: 2026/06/23
Ferraretti GiuliaAlberti MartaCicolini RositaPognant Viù SabrinaSarno StefaniaSazzini Marco