COG1 antibody
- Known as:
- COG1 (anti-)
- Catalog number:
- orb101518
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- COG1 antibody
Related genes to: COG1 antibody
- Gene:
- COG1 NIH gene
- Name:
- component of oligomeric golgi complex 1
- Previous symbol:
- LDLB
- Synonyms:
- KIAA1381
- Chromosome:
- 17q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-07-31
- Date modifiied:
- 2019-04-16
Related products to: COG1 antibody
Related articles to: COG1 antibody
- BackgroundPreclinical studies suggest β-adrenergic receptor agonists may exert neuroprotective effects, but evidence in human populations is limited.ObjectiveTo examine the association between β-adrenergic receptor agonist use and cognitive performance in older adults.MethodsThis retrospective cohort study linked Dutch pharmacy dispensing records (IADB.nl) with Lifelines cohort data. Participants aged ≥50 years with ≥1 prescription for β-adrenergic receptor agonists or reference medications (COPD/cardiovascular) within 365 days prior to baseline cognitive testing were included. Cognitive function was assessed using the Cogstate Brief Battery. Linear mixed models adjusted for demographic, clinical, and lifestyle factors evaluated longitudinal changes.ResultsA total of 3179 participants were included (249 β-adrenergic receptor agonist users, 2930 reference). The exposed group was younger (mean age 58.6 ± 7.4 years versus 63.7 ± 9 years) and included a higher proportion of females (68.2% versus 58.6%) compared with the referent group. At baseline, groups were similar in most cognitive domains, except for slightly higher attention (COG2) scores in the reference group (p = 0.010). Over time, psychomotor speed (COG1), attention (COG2), and visual learning (COG4) remained stable across groups. Working memory (COG3) declined significantly in both groups, with a steeper decline in the reference cohort (p = 0.048).ConclusionsIn this exploratory cohort study, β-adrenergic receptor agonist use was not associated with broad cognitive benefits, though a modest attenuation of working memory decline was observed. These results highlight the need for larger, prospective studies to clarify whether specific subgroups or drug formulations may offer cognitive advantages. - Source: PubMed
Publication date: 2026/06/09
Alghamdi AliCombrtg ElizabethBalafas SpyrosBos Jens H JVan Munster Barbara CSchmidt MartinaHak Eelko - Neuronal identity is established and maintained by "terminal-selector" transcription factors, yet how these networks evolve remains unclear. We examined the specification of the chemosensory ASE and thermosensory AFD neurons in the nematode Pristionchus pacificus, a species that expresses the terminal-selector, Ppa-CHE-1, in both sensory neurons. To determine if the ASE neurons exhibit left-right laterality, we used HCR-FISH and transgenic reporters to discover 8 ASE left-right-specific and 3 AFD-specific receptor-type guanylyl-cyclases. Late embryos exhibit a multipotential state in which AFD precursors transiently co-express all three types of ASEL, ASER and AFD markers. A forward genetic screen for defects in ASER asymmetry identified a Ppa-DIE-1 homolog, whereas targeted mutations revealed the maintenance of AFD neuronal identity requires another terminal-selector, Ppa-TTX-1, and CNG channels, Ppa-TAX-2/TAX-4. Mutations in the microRNA miR-8345 and pash-1 responsible for miRNA-processing convert ASEL to ASER fate while changes to other conserved regions in the 3' UTR of the cog-1 homolog reveal multiple sites that act as a toggle between left/right ASE versus AFD identities. Together, these results demonstrate that P. pacificus deploys a miRNA-mediated regulatory repertoire to generate three distinct neuronal fates through the Ppa-cog-1 3' UTR as a key regulatory nexus. - Source: PubMed
Publication date: 2026/02/11
Castro Dylan LDimov Ivan MMackie MarisaCarstensen Heather RBarsegyan Mary THong Ray L - Rice ( L.) is a staple crop. It was originally domesticated in tropical and subtropical regions, sustains nearly half of the global population and contributes approximately 20% of the world's total dietary energy supply. However, its inherent sensitivity to low-temperature severely threatens yield stability. To meet the growing global food demand, rice cultivation is expanding to low-temperature-prone high-altitude and high-latitude regions. This expansion makes the low-temperature sensitivity problem worse. To cope with cold stress, rice has evolved a sophisticated regulatory network for cold sensing, signal transduction, and response. Recent research progress includes identifying key sensors (COLD1-RGA1, COG1-OsSERL2), characterizing secondary messengers (Ca², 2',3'-cAMP, ROS) and downstream cascades (CBL-CIPK, CDPK, MAPK), elucidating core transcriptional modules (OsbHLH002/OsICE1-OsDREBs-COR) and auxiliary transcriptional factors (WRKY, MYB, NAC), uncovering critical genes involved in membrane lipid remodeling, and defining the roles of phytohormones (ABA and GA) that fine-tune cold stress responses. This review summarizes current understanding of these molecular mechanisms and highlights future directions for rice cold stress research. - Source: PubMed
Publication date: 2026/01/05
Xiao PeixiangXiong MeixinHou KexinGuo XueyanLi HuaLiu Yi - BackgroundThe Mini-Cog is a brief cognitive examination comprising a three-item memory recall and a simplified Clock Drawing Test (CDT). There is limited research on the effects of detailed scoring criteria for the Mini-Cog on cognitive screening.ObjectiveTo assess the diagnostic effectiveness of three Mini-Cog versions and a new process-based CDT test in identifying mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared to cognitively normal controls (NC).MethodsWe prospectively enrolled 950 subjects who underwent standardized neuropsychological assessments and the Mini-Cog test. The CDT was scored using an adapted 10-point scale. The accuracy of three Mini-Cog versions (Mini-Cog1: 3-word delayed recall + 2-point CDT; Mini-Cog2: 3-word immediate recall + 3-word delayed recall + 3-point CDT; Mini-Cog3: 3-word immediate recall + 3-word delayed recall + 10-point CDT) was assessed through the receiver operating characteristic analysis. Sensitivity and specificity were determined for each diagnostic threshold.ResultsThe optimal cut-off point for Mini-Cog3 is 12/16 for MCI and 10/16 for AD. Mini-Cog3 demonstrated the highest diagnostic efficacy, with AUCs of 0.82 (95% CI: 0.78-0.85) for MCI and 0.95 (95% CI: 0.94-0.97) for AD, with sensitivity of 85% for both MCI and AD. The CDT's AUCs were 0.77 (95% CI: 0.73-0.81) for MCI, and 0.87 (95% CI: 0.84-0.90) for AD, with sensitivity of 89% for MCI, and 82% for AD.ConclusionsA more elaborate scoring system, such as Mini-Cog3, may serve as an effective screening method for the rapid and accurate detection of cognitive dysfunction in patients with MCI and AD. - Source: PubMed
Publication date: 2025/02/18
Yang QianYang HaoLong WeiZuo ShengZhu DefaGuo Qihao - Early detection of dementia enables more effective planning and can enable access to treatment and support. The Mini-Cog is a widely used screening instrument in Indonesia; however, this instrument has never undergone a translation and cultural adaptation process. Currently, there is no data on how accurate the tool is against diagnostic criteria, particularly in low-education. - Source: PubMed
Turana YudaFarina NicolasTheresia ImeldaSani Tara PuspitariniSuswanti IkaFitri Fasihah IrfaniAlbanese EmilianoComas-Herrera AdelinaKnapp MartinBanerjee Sube