RNF43 antibody
- Known as:
- RNF43 (anti-)
- Catalog number:
- orb101533
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- RNF43 antibody
Related genes to: RNF43 antibody
- Gene:
- RNF43 NIH gene
- Name:
- ring finger protein 43
- Previous symbol:
- -
- Synonyms:
- FLJ20315, DKFZp781H0392, URCC
- Chromosome:
- 17q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-04-18
- Date modifiied:
- 2019-04-23
Related products to: RNF43 antibody
Related articles to: RNF43 antibody
- Colorectal cancer (CRC) incidence and mortality rates differ by population, and evidence suggests that genetic differences may affect cancer biology. However, studies investigating CRC variants in genetically heterogeneous populations are limited. Using somatic tumor mutation profiling of CRCs diagnosed in African Americans (AAs), Ghanaians, Ethiopians, and NHWs, we explore correlations between population group and population-specific tumor variants. - Source: PubMed
Publication date: 2026/06/29
Mabvakure Batsirai MPromprasert PatharapaMartinez Cruz LuciaPatil SiddhiBarros JohnHayhurst MatthewMohebbi Elhamde la Caridad Delgado Herrera DeborahLee GraceLatif SophiaWilliams FionaSamdani RashmiDuttargi AnjuBerhane BereketBesufikad EsmaelTadesse SelamawitJibril Suleiman AishaLefante ChristinaHsieh Mei-ChinPurrington KristenAdjei ErnestQin TingtingSartor MaureenStoffel Elena MRozek Laura S - The WNT signaling pathway regulates cell proliferation and stem cell maintenance. Its sustained and inappropriate activation results in excessive cell division and cancer. WNT signaling is activated upon interaction of the soluble WNT ligand with the Frizzled (FZD) receptor. The RING E3 ubiquitin ligases RNF43 and ZNRF3 promote the ubiquitylation and internalization of FZD, thereby turning off WNT signaling, and their inactivation causes cancer. Here, we identified the determinants of ubiquitin transfer by ZNRF3 and RNF43 and report the structure of the RING domain from ZNRF3. We found that the RING domain was monomeric and that RING dimerization was not required for its ubiquitin ligase activity. However, the ectodomain of ZNRF3 dimerizes, and our data supported a model in which the cytoplasmic domains are in close proximity in cells and interact, even though RING dimerization was not required for ubiquitin transfer. Our studies provide a framework for understanding how the E3 ubiquitin ligase activity of ZNRF3 and RNF43 is regulated. - Source: PubMed
Publication date: 2026/06/30
Padala PrasanthRossig ClaudiaCrowther Jennifer MDobson Renwick C JPatel MonicaKumar AbhishekKleffmann TorstenMiddleton Adam JDay Catherine L - Hofbauer cells are fetal macrophages in the placental villous core that contribute to maternal-fetal tolerance and antiviral defense, but how their immune programs change across gestation in response to viral exposure remains poorly understood. - Source: PubMed
Publication date: 2026/06/09
Schuch VivianeHossack DanielHailstorks TiffanyChakraborty RanaJohnson Erica L - Fasting enhances small intestinal regeneration after radiation, but the contribution of the gut microbiome to this process remains uncharacterized. We identify () as a key mediator of this response. was enriched in fasted mice and its antibiotic depletion abrogated radioprotection, whereas reintroduction restored both organismal survival and intestinal integrity. Fasting elevated propionic acid, consistent with 's metabolic output. -conditioned medium and propionate induced histone H3 acetylation in intestinal stem cell cultures while in vivo fasting induced -dependent H3K27ac and H3K9ac, remodeling promoter-enhancer landscapes in crypt epithelial cells. Epigenetic profiling revealed a rewired core regulatory program enriched for pioneer transcription factors (Foxa, Gata, Klf), architectural organizers (Ctcf, Boris), and lineage-defining and metabolic regulators (Cdx2, Hnf4). This program supports expansion of a population of primed persister cells characterized by open chromatin accessibility at key stem and regenerative-associated loci including , , These findings define a fasting-induced microbiome-metabolite-chromatin axis that epigenetically primes highly plastic persister cells for rapid regeneration of the intestinal epithelium following radiation-induced injury. - Source: PubMed
Publication date: 2026/06/23
Barrodia PraveenSaw Ajay KumarJeter-Jones Sabrina LChang Chia-ChiShao JiansuArslan EmreSingh Anand KSatpati SureshJenq Robert RRai KunalPiwnica-Worms Helen - HLA-E presented cancer peptides can be promising cancer therapy targets, as HLA-E is minimally polymorphic and widely expressed across human populations and cancer types. However, systematic discovery of cancer associated HLA-E peptides has been constrained by sparse training data and the technical difficulty of HLA-E immunopeptidomics. Here we develop an integrated HLA-E antigen discovery platform combining a deep learning prediction model, pooled mammalian cell screening, peptide-HLA-E stability validation, and mass spectrometry. We introduce MHC Attention, a neural network that learns allele-level attention over candidate MHC alleles in multi-allele immunopeptidomics datasets, enabling direct training on patient-derived MHC peptide data. Screening an approximately 6,000-peptide HLA-E library identified stable HLA-E-presented peptides and generated HLA-E-specific training data that improved prediction performance of MHC Attention. Combining our screening assays and improved prediction algorithm, we discovered novel HLA-E-presented cancer peptides, including candidates derived from ETV4, WT1, RNF43 and BMP8A, with orthogonal support from stability assays or immunopeptidomics. These results establish a scalable framework for HLA-E peptide target discovery and provide candidate targets for broadly applicable peptide-HLA-directed cancer immunotherapies. MHC Attention 2.0 can be accessed online via https://vcreate.io/mhcattention . - Source: PubMed
Publication date: 2026/06/10
Fast EthanDhar ManjimaGulati Gunsagar SKu MillicentChen Binbin