CDC14B antibody
- Known as:
- CDC14B (anti-)
- Catalog number:
- orb101572
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- CDC14B antibody
Related genes to: CDC14B antibody
- Gene:
- CDC14B NIH gene
- Name:
- cell division cycle 14B
- Previous symbol:
- -
- Synonyms:
- Cdc14B1, Cdc14B2, CDC14B3, hCDC14B
- Chromosome:
- 9q22.32-q22.33
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-18
- Date modifiied:
- 2018-02-13
- Gene:
- CDC14C NIH gene
- Name:
- cell division cycle 14C
- Previous symbol:
- -
- Synonyms:
- MGC26484, CDC14B2, CDC14Bretro, CDC14CP
- Chromosome:
- 7p12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-03-09
- Date modifiied:
- 2017-12-06
Related products to: CDC14B antibody
Related articles to: CDC14B antibody
- The budding yeast phosphatase Cdc14 has a central role in mitotic exit and cytokinesis. Puzzlingly, a uniform picture for the three human CDC14 paralogues CDC14A, CDC14B and CDC14C in cell cycle control has not emerged to date. Redundant functions between the three CDC14 phosphatases could explain this unclear picture. To address the possibility of redundancy, we tested expression of and analysed cell cycle progression of cells with single and double deletions in genes. Our data suggest that is not expressed in human RPE1 cells, excluding a function in this cell line. Single- and double-knockouts (KO) of and in RPE1 cells indicate that both phosphatases are not important for the timing of mitotic phases, cytokinesis and cell proliferation. However, cycling KO and KO cells show altered ciliogenesis compared to wild-type cells. The cilia of cycling KO cells are longer, whereas KO cilia are more frequent and disassemble faster. In conclusion, this study demonstrates that the cell cycle functions of CDC14 proteins are not conserved between yeast and human cells. - Source: PubMed
Publication date: 2021/01/27
Partscht PatrickUddin BorhanSchiebel Elmar - CDC14 was originally identified by L. Hartwell in his famous screen for genes that regulate the budding yeast cell cycle. Subsequent work showed that Cdc14 belongs to a family of highly conserved dual-specificity phosphatases that are present in a wide range of organisms from yeast to human. Human CDC14B is even able to fulfill the essential functions of budding yeast Cdc14. In budding yeast, Cdc14 counteracts the activity of cyclin dependent kinase (Cdk1) at the end of mitosis and thus has important roles in the regulation of anaphase, mitotic exit and cytokinesis. On the basis of the functional conservation of other cell-cycle genes it seemed obvious to assume that Cdc14 phosphatases also have roles in late mitosis in mammalian cells and regulate similar targets to those found in yeast. However, analysis of the human Cdc14 proteins (CDC14A, CDC14B and CDC14C) by overexpression or by depletion using small interfering RNA (siRNA) has suggested functions that are quite different from those of ScCdc14. Recent studies in avian and human somatic cell lines in which the gene encoding either Cdc14A or Cdc14B had been deleted, have shown - surprisingly - that neither of the two phosphatases on its own is essential for viability, cell-cycle progression and checkpoint control. In this Commentary, we critically review the available data on the functions of yeast and vertebrate Cdc14 phosphatases, and discuss whether they indeed share common functions as generally assumed. - Source: PubMed
Mocciaro AnnamariaSchiebel Elmar