NUBP2 antibody
- Known as:
- NUBP2 (anti-)
- Catalog number:
- orb101602
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- NUBP2 antibody
Related genes to: NUBP2 antibody
- Gene:
- NUBP2 NIH gene
- Name:
- nucleotide binding protein 2
- Previous symbol:
- -
- Synonyms:
- CFD1, CIAO6
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-25
- Date modifiied:
- 2018-05-17
Related products to: NUBP2 antibody
Related articles to: NUBP2 antibody
- Jacobsen syndrome, resulting from a terminal deletion of chromosome 11 (11q), may lead to an increased bleeding tendency due to low platelet counts or platelet dysfunction. Currently, information on bleeding tendency and platelet function in patients with nonterminal 11q-aberrations such as larger deletions, interstitial 11q-deletions, or 11q-duplications is lacking. - Source: PubMed
Publication date: 2025/07/22
Huisman Elise JDalm Virgil A S HJoosten MariekeSmiers Frans JPorcelijn LeendertHoogendijk ArjanJanssen Hansvan der van der Wel Nicole NKremer Hovinga Idske C Lde Haas MasjaCnossen Marjon H - Liver fibrosis is a vital cause of morbidity in patients with liver diseases and developing novel anti-fibrotic drugs is imperative. Isovalerylspiramycin I (ISP I) as a major component of carrimycin applied to upper respiratory infections, was first found to possess anti-fibrotic potential. The present study aims to evaluate the functions and mechanisms of ISP I in protecting against liver fibrosis. According to our results, ISP I not only reduced the expressions of fibrogenic markers in LX-2 cells but also appeared great protective effects on liver injury and liver fibrosis in bile duct ligation (BDL) rats and carbon tetrachloride (CCl) mice. We proved that nucleotide-binding protein 2 (NUBP2) was the direct target of ISP I. ISP I through targeting NUBP2, increased the amount of vascular non-inflammatory molecule-1 (VNN1) on the cell membrane, which will inhibit oxidative stress and fibrosis. Simultaneously, the original carrimycin's protective effect on liver damage and fibrosis was verified. Therefore, our study provides potential agents for patients with liver fibrosis-related diseases, and the clear mechanism supports wide application in the clinic. - Source: PubMed
Publication date: 2024/07/18
Zhang NaNiu WeixiaoNiu WeipingLi YimingGuo SiminLi YangHe WeiqingHe Hongwei - Microcephaly affects 1 in 2,500 babies per year. Primary microcephaly results from aberrant neurogenesis leading to a small brain at birth. This is due to altered patterns of proliferation and/or early differentiation of neurons. Premature differentiation of neurons is associated with defects in the centrosome and/or primary cilia. In this study, we report on the first patients identified with -deficiency and utilize a conditional mouse model to ascertain the molecular mechanisms associated with -deficient primary microcephaly. We identified homozygous variants in these patients who displayed profound primary microcephaly in addition to intrauterine growth restriction, cervical kyphosis, severe contractures of joints, and facial dysmorphia. We then generated a mouse model using to ablate from the forebrain. The mice presented with severe microcephaly starting at E18.5. Neurospheres generated from the forebrain of conditional deletion mice were used to support the pathogenicity of the patient variants. We show that loss of increases both canonical and non-canonical cell death, but that loss of fails to rescue microcephaly in the mouse model. Examination of neurogenesis in mice revealed distinct alterations in proliferation and cellular migration accompanied by supernumerary centrosomes and cilia. We therefore propose that is a novel primary microcephaly-related gene and that the role of in centrosome and cilia regulation is crucial for proper neurogenesis. - Source: PubMed
Publication date: 2025/01/17
Rushforth RebekahShamseldin Hanan ECostantino NicoleMichaels Jes-RiteSawyer Sarah LOsmond MatthewKurdi WesamAbdulwahab FirdousDiStasio Andrew Boycott Kym MAlkuraya Fowzan SStottmann Rolf W - Colorectal cancer (CRC), a digestive tract malignancy with high mortality and morbidity, lacks effective biomarkers for clinical prognosis due to its complex molecular pathogenesis. Nucleotide binding protein 2 (NUBP2) plays a vital role in the assembly of cytosolic Fe/S protein and has been implicated in cancer progression. In this study, we found that NUBP2 was highly expressed in CRC by TCGA database analysis. Subsequently, we verified the expression of NUBP2 in CRC tumor tissues and para-carcinoma tissues using IHC staining, and further investigated its association with clinicopathological parameters. In vitro cell experiments were conducted to assess the role of NUBP2 in CRC by evaluating cell proliferation, migration, and apoptosis upon NUBP2 dysregulation. Furthermore, we established a subcutaneous CRC model to evaluate the impact of NUBP2 on tumor growth in vivo. Additionally, we performed mechanistic exploration using a Human Phospho-Kinase Array-Membrane. Our results showed higher expression of NUBP2 in CRC tissues, which positively correlated with the pathological stage, indicating its involvement in tumor malignancy. Functional studies demonstrated that NUBP2 knockdown reduced cell proliferation, increased apoptosis, and impaired migration ability. Moreover, NUBP2 knockdown inhibited tumor growth in mice. We also observed significant changes in the phosphorylation level of GSK3β upon NUBP2 knockdown or overexpression. Additionally, treatment with CHIR-99021 HCl, an inhibitor of GSK3β, reversed the malignant phenotype induced by NUBP2 overexpression. Overall, this study elucidated the functional role of NUBP2 in CRC progression both in vitro and in vivo, providing insights into the molecular mechanisms underlying CRC and potential implications for targeted therapeutic strategies. - Source: PubMed
Publication date: 2024/03/16
Lan DanfengWang JunyuSun GuishunJiang LixiaChen QiyunLi ShaQu HaiyanWang YiboWu Bian - Oral Squamous Cell Carcinoma (OSCC), a common malignancy of the head and neck region, is frequently diagnosed at advanced stages, necessitating the development of efficient diagnostic methods. Profiling autoantibodies generated against tumor-associated antigens have lately demonstrated a promising role in diagnosis, predicting disease course, and response to therapeutics and relapse. - Source: PubMed
Publication date: 2023/09/22
Abdulla RiazDevasia Puthenpurackal JofyPinto Sneha MRekha Punchappady DevasyaSubbannayya Yashwanth