PCDHB13 antibody
- Known as:
- PCDHB13 (anti-)
- Catalog number:
- orb101645
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- PCDHB13 antibody
Related genes to: PCDHB13 antibody
- Gene:
- PCDHB13 NIH gene
- Name:
- protocadherin beta 13
- Previous symbol:
- -
- Synonyms:
- PCDH-BETA13
- Chromosome:
- 5q31.3
- Locus Type:
- protocadherin
- Date approved:
- 2000-06-28
- Date modifiied:
- 2016-10-05
Related products to: PCDHB13 antibody
Related articles to: PCDHB13 antibody
- Non-small cell lung cancer (NSCLC) is among the leading causes of human mortality. One reason for high rates of NSCLC mortality is that drug resistance is a major problem for both conventional chemotherapies and less-toxic targeted therapies. Thus, novel mechanistic insights into disease pathogenesis may benefit the development of urgently needed therapies. Here we show that FBJ murine osteosarcoma viral oncogene homolog B (FOSB) was induced by an antimicrobial peptide, tilapia piscidin-4 (TP4), through the dysregulation of mitochondrial Ca homeostasis in NSCLC cells. Transcriptomic, chromatin immunoprecipitation quantitative PCR, and immunocytochemical studies reveal that protocadherin-β13 () as a target of FOSB that was functionally associated with microtubule. Overexpression of either PCDHB13 or FOSB attenuated NSCLC growth and survival in vitro and in vivo. Importantly, downregulation of both FOSB and PCDHB13 was observed in NSCLC patients and was negatively correlated with pathological grade. These findings introduce the FOSB⁻PCDHB13 axis as a novel tumor suppressive pathway in NSCLC. - Source: PubMed
Publication date: 2019/01/17
Ting Chen-HungLee Kang-YunWu Sheng-MingFeng Po-HaoChan Yao-FeiChen Yi-ChunChen Jyh-Yih