MUC15 antibody
- Known as:
- MUC15 (anti-)
- Catalog number:
- orb101650
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- MUC15 antibody
Related genes to: MUC15 antibody
- Gene:
- MUC15 NIH gene
- Name:
- mucin 15, cell surface associated
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11p14.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-11-26
- Date modifiied:
- 2014-11-18
Related products to: MUC15 antibody
Related articles to: MUC15 antibody
- Mucin is a highly glycosylated macromolecular protein that is widely present in the mucosal tissues of fish. MUC15 has been identified in humans and higher vertebrates as playing a significant role in maintaining the mucosal barrier and regulating various signaling pathway. However, the potential role of mucin15 in fish immune responses remains poorly understood. In this study, mucin15 derived from fat greenling (Hexagrammos otakii) was identified and characterized, designated as Homuc15. The genomic DNA full length of Homuc15 was 14110 bp with an open reading frame (ORF) (1245 bp), encoding a polypeptide of 414 amino acids. The theoretical molecular weight of the HoMUC15 protein was 43.9 kDa. Subcellular localization analysis indicated that HoMUC15 was predominantly distributed in the extracellular matrix. Sequence alignment and phylogenetic tree analysis revealed that HoMUC15 was structurally similar to MUC15 orthologs from other teleost fish and displayed a high degree of conservation. Moreover, Homuc15 exhibited widespread expression across mucosal immune tissues, including skin, intestine, and gill. Its expression level in the skin was upregulated following stimulation with Vibrio harveyi. Furthermore, recombinant HoMUC15 (rHoMUC15) specifically bound to a variety of bacteria. The rHoMUC15 was able to bind PAMPs such as lipopolysaccharide (LPS), peptidoglycan (PGN), and Polyinosinic-polycytidylic acid (Poly I:C) in a concentration-dependent manner. However, antibacterial assays demonstrated that rHoMUC15 could not directly inhibit bacterial growth, bacterial agglutination assays indicated that rHoMUC15 was capable of agglutinating Vibrio harveyi, Bacillus subtilis, and Edwardsiella tarda in a Ca-dependent manner. Meanwhile, rHoMUC15 was found to promote the clearance of Vibrio harveyi from the immune tissues of Hexagrammos otakii. Collectively, these findings suggest that HoMUC15 possesses the ability to bind and agglutinate bacteria and may act as a pattern recognition receptor to assist Hexagrammos otakii in resisting pathogenic invasion. - Source: PubMed
Publication date: 2026/04/13
Wei XuyaHe TingtingWei XiaoyanZhang ZhengWenyu YouminZhang YamingZhang YunuoZhang YingxueLi XuejieWang Wei - Gastric cancer (GC) is a lethal digestive malignancy with poor outcomes. Although N7-Methylguanosine (m7G) modification and immune-related genes (IRGs) individually affect GC prognosis and the tumor microenvironment, their mechanistic crosstalk remains unclear. Differentially expressed genes (DEGs) in GC were identified and used alongside m7G-related genes (m7G-RGs) to perform consensus clustering, defining molecular subtypes and yielding additional DEGs. Intersection of these gene sets identified m7G-related immune genes. Prognostic genes were selected via Least Absolute Shrinkage and Selection Operator (LASSO), and Cox regression analysis to construct a validated prognostic risk model. Associations between clinicopathological features and risk scores were assessed, identifying independent prognostic factors and enabling nomogram development. The risk-stratified groups underwent gene set enrichment analysis (GSEA), immune infiltration, tumor immune dysfunction and exclusion (TIDE), tumor purity, drug sensitivity, and tumor mutation burden (TMB) analyses. Using GC and normal samples, this study identified 4,458 DEGs. Intersection with subtype-specific DEGs (2,098) and immune genes (4,172) yielded 193 m7G-associated immune genes. Six prognostic genes (ELANE, ASCL2, APOA1, GRP, CD36, MUC15) were used to construct a prognostic risk model that stratified patients into high- and low-risk groups with significant survival differences and strong predictive accuracy. Age, stage, and risk score were independent prognostic factors, and a nomogram was developed. High-risk patients showed enrichment in tumor-promoting pathways (e.g., calcium signaling), immunosuppressive microenvironments, higher stromal scores, and TP53 mutations. Low-risk patients had activated DNA repair pathways, lower TIDE scores, higher immune infiltration, and TTN mutations. Drug sensitivity analysis identified 130 compounds with differential responses between groups (p < 0.05). This study developed a robust prognostic risk model based on six prognostic genes, which effectively reveals molecular mechanisms and immune features of GC, offering a foundation for individualized therapy. - Source: PubMed
Publication date: 2026/04/14
Li NanYin JieZhao YueFan YaoWei JinmeiGao ZhankunZhang Ruixing - Perineural invasion (PNI) is a critical yet poorly understood feature that significantly influences the prognosis of pancreatic ductal adenocarcinoma (PDAC), a disease notorious for its dismal survival rates. Although PNI is recognized as a hallmark of pancreatic cancer, the molecular mechanisms underlying this process remain complex and incompletely defined. Recent insights into tumor-nerve interactions have highlighted the role of glycocalyx components, particularly mucin 15 (MUC15), in regulating neural invasion. In this study, we demonstrate that loss of MUC15 promotes PNI by activating the IGF1R/STAT3/NGF signaling axis. Specifically, reduced MUC15 expression weakens its interaction with IGF1R, leading to decreased receptor ubiquitination and increased phosphorylation, which in turn activates STAT3 signaling and drives NGF transcription and secretion. Loss of MUC15 also promotes epithelial-mesenchymal transition (EMT) and alters interactions with the tumor microenvironment, further facilitating neural invasion. Importantly, pharmacologic inhibition of IGF1R reverses these effects, suggesting that restoring MUC15 expression or targeting the IGF1R/STAT3-NGF axis may represent a potential therapeutic strategy to limit PNI in pancreatic cancer. These findings reveal a novel regulatory pathway connecting tumor-intrinsic signaling, EMT, and the neural microenvironment in PDAC progression. - Source: PubMed
Publication date: 2026/02/23
Zhang SimeiQin TaoWu ShuaiZhu ZeenZhang WunaiSong YiqunWei WanzhenCao RuiqiLiu DongmeiZhu HaoyangLi JianpengYue YangyangQian WeikunZhu YaominWang Zheng - This study aimed to compare the expression of implantation-related genes in trophectoderm cells between normally developing (day 5) and delayed (day 6) euploid blastocysts. - Source: PubMed
Publication date: 2025/12/24
Suwandee ChularatThuwanut PaweenaSuebthawinkul ChanakarnTuntiviriyapun Punkavee - A limited supply and price shortages of fishmeal with the expansion of aquaculture make it necessary to seek alternative protein sources. Soybean meal (SM) has been the widely preferred replacer for fishmeal in fish diets. Nevertheless, this substitution, especially when given at high doses, potentially shows adverse impact on fish intestinal health. This study aimed to investigate the effect of replacing fishmeal with SM on intestinal health in olive flounder (). A 56-day feeding trial was conducted with 450 juvenile fish (initial weight: 6.32 ± 0.01 g) randomly allocated to five diets with graded SM replacement: 0% (FM), 12% (SM12), 24% (SM24), 36% (SM36), and 48% (SM48). The results demonstrated that concentrations of glucose, total triglyceride, and low-density lipoprotein cholesterol increased, whereas total protein and high-density lipoprotein cholesterol contents, and lysozyme activity decreased in serum with increasing dietary SM levels. Meanwhile, total antioxidant capacity and superoxide dismutase activity significantly decreased at replacement levels exceeding 24%, accompanied by elevated malondialdehyde concentration ( < 0.05). Compared with the FM group, the SM24, SM36, and SM48 groups showed significantly reduced VH and increased lamina propria width ( < 0.05). Increasing dietary SM levels upregulated expression of genes related to endoplasmic reticulum stress (ERS) (, , and ), inflammation ( and ), and apoptosis (, , , and ), while downregulated anti-inflammatory cytokines ( and ) and tight junction-related genes (, , , , , and ) in the intestine ( < 0.05). There were significant differences in the abundances of intestinal microbiota at both the phylum and genus levels among the FM, SM24, and SM36 groups ( < 0.05), but the clusters and microbiota composition of the SM24 group were more similar to those of the FM group. In conclusion, replacing 24% of fishmeal with SM induced intestinal dysfunction through evoking ERS, inflammation, barrier disruption, and microbial dysbiosis in olive flounder. - Source: PubMed
Publication date: 2025/10/03
Su ZhenxiaZhang YanjieWei ChaoqingZhang FengxiangWang LeiLi YaxuanZhang ZhengqiuXu JianheDong ZhiguoMu Hua