DDCT antibody
- Known as:
- DDCT (anti-)
- Catalog number:
- orb101707
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- DDCT antibody
Ask about this productRelated genes to: DDCT antibody
- Gene:
- DDT NIH gene
- Name:
- D-dopachrome tautomerase
- Previous symbol:
- -
- Synonyms:
- DDCT, MIF2, MIF-2, D-DT
- Chromosome:
- 22q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-06
- Date modifiied:
- 2018-02-16
Related products to: DDCT antibody
Related articles to: DDCT antibody
- Legacy pollutants continue to be detected in wildlife and ecosystems, even decades after regulatory action. The study provides the first comprehensive assessment of polychlorinated biphenyls (PCB congeners 28, 52, 101, 138, 153, 180) and chlorinated pesticides, including hexachlorobenzene (HCB), hexachlorocyclohexane (HCH), and dichlorodiphenyltrichloroethane (DDT) and its metabolites in Black-headed Gull (Chroicocephalus ridibundus) eggs from the southern Baltic Sea, covering the largest breeding colonies between Germany and Poland. Sampling was conducted over 2 consecutive years. All eggs (n = 60) contained DDT and its metabolites and PCB congeners above the reporting level, with mean total PCB concentrations of 0.135-0.268 mg/kg and mean total DDT concentrations of 0.42-0.63 mg/kg. HCB was quantified at low levels (0.01-0.02 mg/kg) in five eggs, which does not allow conclusions about site-specific sources. HCH was not quantified in any sample. No relationships were found between contaminant concentrations and biometric parameters. The consistent occurrence and concentrations of PCBs and DDT metabolites highlight the enduring environmental relevance of these substances. Acute toxic effects were not directly assessed in this study; only associations with measured endpoints were evaluated. Our findings provide crucial new baseline data for the Baltic Sea region and reinforce the value of Black-headed Gull eggs as bioindicators of legacy and chemical exposure. - Source: PubMed
Publication date: 2026/10/07
Wlodarz MagdalenaHabedank FriederikeOrnés Angela Schmitz - An industry-wide survey of 26 biopharmaceutical companies benchmarked artificial intelligence and machine learning (AI/ML) adoption in translational and ADME sciences. AI/ML is widely used in early discovery and small-molecule workflows but rarely the primary driver of decision making. Data quality and organizational readiness were identified as key barriers to adoption. Respondents highlighted molecular design and hybrid mechanistic-AI approaches as key opportunities. Beyond benchmarking adoption, this work provides cross-industry perspectives on the scientific, organizational and data foundations needed to scale impact through integrated workflows, shared benchmarks and collaborative translational decision-making. - Source: PubMed
Publication date: 2026/10/07
Abbasi ArminaGonzalez-Franquesa AlbaMcCoy MichaelGöller Andreas HGuo YukuangClifton JamieOrsi MarkusPillai NikhilMitra KaushikArgikar Upendra AGeneraux Grant TSubramanian MuraliPrakash ChandraLicznar AnneKanodia JitendraWester Michael RZhang Peter Zhiping - We propose an evidence-weighted atlas for drug repurposing and antiviral activity expansion. Instead of using a universal viral phylogeny, our framework matches the way in which viruses are represented to the pharmacological question being asked. The atlas integrates five distinct layers: closely related viruses are represented in whole-genome trees, homologous drug targets in target-specific polymerase or protease trees, deeply diverged virion proteins in structure-derived trees, convergent cellular vulnerabilities in host-dependency networks, and a complementary view of chemical space, linking scaffold variation to breadth, potency and resistance liability, in antiviral structure-activity relationship trees. Candidate drug or activity transfers are filtered by pocket conservation, intracellular activation, tissue exposure, safety and resistance barriers. Successful and failed combinations calibrate the framework, which prioritizes the smallest justified 2-4-agent regimen for untreated viruses and Pathogen X. - Source: PubMed
Publication date: 2026/10/07
Bespalov Maxim MIanevski AleksandrRavlo ErlendBjørås MagnarKainov Denis E - Real-world evidence (RWE) is increasingly included in marketing authorization applications, and plays a growing role in regulatory decision-making. Although commonly included in product labels as safety information, its use for efficacy claims remains limited and randomized controlled trials (RCTs) remain the gold-standard. Regulatory guidance on the use of RWE is expanding, but a significant gap remains regarding its role in labeling, particularly for communicating drug effectiveness. This review examines how real-world evidence (RWE) has been used in many therapeutic areas to support efficacy claims in drug product labels approved by the US Food & Drug Administration (FDA) and the European Medicines Agency (EMA). A systematic search identified 173 brands that included RWE as primary efficacy evidence, as an external comparator to single-arm trials, or as supportive evidence alongside RCTs. This work offers insights for designing RWE studies that support labeling claims and inform regulatory guidance. - Source: PubMed
Publication date: 2026/10/07
Cruz Ana GlóriaRancan ChiaraCerruti ElisaKaufmann IsabellaFalconnier-Williams OliviaFalconnier Ariane - Central auditory processing disorder (CAPD) has been linked separately to developmental stuttering (DS) and developmental dyslexia (DD), with limited information available when both disorders are present. Our study aimed to evaluate central auditory processing (CAP) in children with both disorders. - Source: PubMed
Publication date: 2026/09/30
Radwan Alaa Mamdouh AbdelhamedAbdelmotaleb HebatAllah Ismail