NUP37 antibody
- Known as:
- NUP37 (anti-)
- Catalog number:
- orb101792
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- NUP37 antibody
Related genes to: NUP37 antibody
- Gene:
- NUP37 NIH gene
- Name:
- nucleoporin 37
- Previous symbol:
- -
- Synonyms:
- MGC5585, FLJ22618
- Chromosome:
- 12q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-19
- Date modifiied:
- 2016-06-01
Related products to: NUP37 antibody
Related articles to: NUP37 antibody
- Despite the central role of the nucleus in the cell, it remains unclear what determines nuclear size. Previous studies suggest a correlation between nuclear and cell size. However, many neurons have massive axon arbors, while maintaining a typical nuclear size. Here, we show a marked reduction of nuclear, but not cell, size during the direct conversion of human fibroblasts to induced neurons by ASCL1, miR124-9-9, and p53 short hairpin RNA (shRNA) (AMp). Similar nuclear shrinkage was observed in the maturation of induced pluripotent stem cell-derived human cortical neurons. ASCL1 suppressed the transcription of the nucleoporin NUP37 by direct binding to its promoter. NUP37 knockdown enhanced AMp-mediated transdifferentiation and nuclear shrinkage, while NUP37 overexpression achieved the opposite. It appears that ASCL1 promotes nuclear shrinkage by suppressing NUP37 and reducing the nuclear pore complex (NPC), which gates nuclear transport. The study suggests a critical role of NPC in controlling nuclear size to match cell state. - Source: PubMed
Publication date: 2026/02/26
Fisher EmilyJiang ZhongjiaoLi LiChhetri GauravSaleem KomalYan ZhenFeng Jian - Lung adenocarcinoma (LUAD) is a common histopathological variant of non-small cell lung cancer. Individuals with type 2 diabetes (T2DM) face an elevated risk of developing LUAD. We examined the common genomic characteristics between LUAD and T2DM through bioinformatics analysis. - Source: PubMed
Publication date: 2025/03/25
Nueraihemaiti NuerbiyeDilimulati DilihumaBaishan AlharHailati SendaerMaihemuti NulibiyaAikebaier AlifeiyePaerhati YipaerguliZhou Wenting - Asian elephants () provide a unique model for studying cloning in large mammals. As an endangered species with declining populations and limited oocyte availability, interspecies somatic cell nuclear transfer (iSCNT) combined with transcriptomic analysis holds promise for advancing iSCNT embryonic arrest development and further facilitating applications in conservation efforts, therapeutic cloning, and regenerative medicine. - Source: PubMed
Publication date: 2025/02/20
Pankammoon PeachanikaQing YuboZhao HengJiao DelingLi HonghuiWang FengchongWiriyahdamrong ThanapaGuo JianxiongLi WenguiChuammitri PhongsakornThitaram ChatchoteWei HongjiangSathanowongs Anucha - Elevated intracellular lipid synthesis is important for hepatocellular carcinoma (HCC) progression. Our study aimed to identify the role of nucleoporin 37 (NUP37) in lipid synthesis and HCC progression. The expression of NUP37 was significantly upregulated in HCC and associated with a poor prognosis. NUP37 silencing suppressed lipid synthesis, proliferation, migration, and invasion of HCC cells in vitro, and restrained tumor growth in xenograft mouse models in vivo. Next, we found the high expression of NUP37 in HCC was related to post-translational modifications. Tripartite motif-containing 28 (TRIM28) was identified as an interacting protein of NUP37 and upregulated its protein level. The subsequent analysis revealed that TRIM28-mediated SUMOylation of NUP37 at Lys114/118/246 inhibited K27-linked polyubiquitination of NUP37, which is one reason for its high expression level in HCC. In conclusion, TRIM28 SUMOylates NUP37 to prevent its ubiquitination and proteasomal degradation, increasing the stability of the NUP37 protein, thereby promoting lipid synthesis and the progression of HCC. - Source: PubMed
Publication date: 2024/09/18
Liu ZhiyiHu QingheLuo QingZhang GuoweiYang WeichaoCao KuanFang RuqiaoWang RenhaoShi HengliangZhang Bin - Nuclear regulation has potential in cancer therapy, with the nuclear pore complex (NPC) serving as a critical channel between the nucleus and cytoplasm, playing a role in regulating various biological processes and cancer. DNA methylation, an epigenetic modification mediated by DNA methyltransferases (DNMTs), influences gene expression and cell differentiation, and is crucial for the development and progression of tumor cells. Gliomas are the most common primary brain tumors, with glioblastoma being particularly aggressive, characterized by invasiveness, migration capability, and resistance to conventional treatments, resulting in poor prognosis. Our study revealed that the expression level of NUP37 affects the proliferation and invasion of glioma cells, and that the overexpression of DNMT1 can alleviate the adverse effects caused by NUP37 depletion. These findings suggest that NUP37 promotes the proliferation and invasion of glioma cells through its interaction with DNMT1. - Source: PubMed
Publication date: 2024/08/22
Lv YongqiangWang ChaolianLiu RuoyuWu ShaoxianChen JunjunZheng XiaoJiang TianweiChen Lujun