ARMC3 antibody
- Known as:
- ARMC3 (anti-)
- Catalog number:
- orb101808
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- ARMC3 antibody
Related genes to: ARMC3 antibody
- Gene:
- ARMC3 NIH gene
- Name:
- armadillo repeat containing 3
- Previous symbol:
- -
- Synonyms:
- FLJ32827, CT81
- Chromosome:
- 10p12.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-12
- Date modifiied:
- 2016-10-05
Related products to: ARMC3 antibody
Related articles to: ARMC3 antibody
- Rotenone is a widely used environmental pesticide, and epidemiological studies suggest that exposure is associated with an increased risk of Parkinson's disease (PD); however, the molecular toxicological basis of this association remains incompletely defined. Ferroptosis is an iron-dependent, lipid peroxidation-driven form of regulated cell death that is relevant to PD and other neurodegenerative disorders. In this study, we provide disease-contextual functional evidence linking ferroptosis to rotenone-induced PD-like neurotoxicity. We combined network toxicology, human PD substantia nigra transcriptomic analysis using GSE7621, and SH-SY5Y cell-based validation. Rotenone-associated targets were predicted and analyzed for ferroptosis-related enrichment, PD transcriptomic signatures were used for disease-contextual candidate prioritization, and selected findings were validated using qPCR, CCK-8, Western blotting, C11-BODIPY lipid peroxidation staining, and transmission electron microscopy. : By further integrating a human PD substantia nigra transcriptomic dataset (GSE7621), we prioritized an 11-gene, PD-contextualized ferroptosis-associated candidate module (, , , , , , , , , , and ). In SH-SY5Y cells, rotenone exposure consistently upregulated this candidate transcriptional module, and this induction was broadly attenuated by the ferroptosis inhibitor ferrostatin-1 (Fer-1). In parallel, orthogonal functional assays supported an iron- and lipid peroxidation-driven injury state under rotenone exposure that was suppressible by ferroptosis inhibition and iron chelation. Finally, we further performed an exploratory drug-gene association screen to prioritize clinically available candidates, and a limited qPCR check suggested that several selected compounds partially attenuated representative hub-gene induction under rotenone exposure. : Collectively, these findings provide disease-contextual and experimentally supported evidence linking rotenone exposure to ferroptosis-associated neurotoxicity, and identify a ferroptosis-responsive transcriptional module for future hypothesis-driven mechanistic investigation. - Source: PubMed
Publication date: 2026/05/22
Chen YimengZhang DingMa JiajiaLi HuixinXu JingrongMa CuixiaLiu YuqianZhao ZhenbingDuffy Garry PMa JunCui Huixian - The Epstein-Barr virus (EBV) infection is nearly ubiquitous and has established links to malignancy and autoimmune disease. Here we evaluate the genetic factors influencing the humoral immune response to EBV and establish a polygenic risk score (PRS) for anti-EBNA1 responses. - Source: PubMed
Publication date: 2026/03/16
Namjou BahramLape MichaelWeirauch Matthew TKaufman Kenneth MKottyan Leah C - Cilia are microtubule-based structures lining epithelial surfaces of many organs and play an essential role in diverse metabolic and developmental processes. Structural or functional disruptions of cilia can lead to ciliopathies affecting multiple organs. Knocking down in revealed reduction in cilia length of 48.9% compared to the control, accompanied by 63.7% reduction in gliding speed. Additionally, knockdown planaria displayed abnormal cilia distribution, particularly in the anterior region. These findings suggest that ARMC3 is essential for maintaining proper motile cilia structure and function and highlight its potential relevance for understanding ciliopathies in humans. - Source: PubMed
Publication date: 2026/01/16
Gogoi ChayanikaPitt RachelMazur KateNaraharisetti RamyasriJohnson Kristen - Expression quantitative trait locus (eQTL) mapping is an effective tool for identifying genetic variations that regulate gene expression. An increasing number of studies suggested that SNPs associated with complex traits in farm animals are considered as expression quantitative trait loci. Identifying eQTLs associated with gene expression levels in the endometrium helps to unravel the regulatory mechanisms of genes related to reproductive functions in this tissue and provides molecular markers for the genetic improvement of high-fertility sow breeding. In this study, 218 RNA-seq data from pig endometrial tissue were used for eQTL analysis to identify genetic variants regulating gene expression. Additionally, weighted gene co-expression network analysis (WGCNA) was performed to identify hub genes involved in reproductive functions. The eQTL analysis identified 34,876 significant cis-eQTLs regulating the expression of 5632 genes (FDR ≤ 0.05), and 90 hub genes were identified by WGCNA analysis. By integrating eQTL and WGCNA results, 14 candidate genes and 16 fine-mapped cis-eQTLs were identified, including , , , , , , , , , , , , , and , which were involved in the physiological processes of reproduction in sows through hormone regulation, cell adhesion, and amino acid and lipid metabolism. These eQTLs regulate the high expression of candidate genes in the endometrium, thereby affecting reproductive-related physiological functions. These findings enhance our understanding of the genetic basis of reproductive traits and provide valuable genetic markers for marker-assisted selection (MAS), which can be applied to improve sow fecundity and optimize breeding strategies for high reproductive performance. - Source: PubMed
Publication date: 2025/04/03
Zeng TongWang JiLiu ZhexiWang XiaofengZhang HanAi XiaohuaDeng XuemeiWu Keliang - Asthenoteratozoospermia is a common cause of male infertility. To further define the genetic causes underlying asthenoteratozoospermia, we performed whole-exome sequencing in a cohort of Han Chinese men with asthenoteratozoospermia. Homozygous deleterious variants of MYCBPAP were first identified in two unrelated Chinese cases. Replication analyses in a French cohort revealed an additional asthenoter-atozoospermia-affected case harboring a homozygous nonsense variant in MYCBPAP. All of the identified MYCBPAP variants were absent or extremely rare in the public human genome databases. Further functional assays indicated remarkably reduced abundance of MYCBPAP in the spermatozoa from MYCBPAP-associated cases. Subsequently, we generated a Mycbpap knockout (Mycbpap) mouse model, which also exhibited male infertility with reduced sperm motility and abnormal morphologies in sperm heads and flagella. Further investigations demonstrated that Mycbpap male mice presented disrupted acrosome biogenesis and abnormally elongated manchette during spermiogenesis. Intriguingly, proteomic analyses indicated that the proteins related to spermatogenesis, acrosomal and flagellar functions were significantly down-regulated in the testes from Mycbpap male mice. Endogenous immunoprecipitation combined with mass spectrometry revealed interactions of MYCBPAP with a ribosome elimination related protein ARMC3 and central apparatus proteins including CFAP65 and CFAP70. Furthermore, MYCBPAP-associated male infertility in humans and mice could be partially overcome by using intracytoplasmic sperm injections. Collectively, these findings illustrate the essential role of MYCBPAP in normal spermatogenesis and homozygous deleterious variants in MYCBPAP can be considered as a genetic diagnostic indicator for infertile men with asthenoteratozoospermia. Our study will provide effective guidance for genetic counseling, clinical diagnosis and assisted reproduction treatments of MYCBPAP-associated male infertility. - Source: PubMed
Publication date: 2024/12/18
Zhou YilingTu ChaofengCoutton CharlesTang JiananTian ShixiongTang ShuyanMartinez GuillaumeZhou DapengTebbakh CéliaWang JiaxiongZouari RaoudhaZhou XuehaiBen Mustapha Selima FouratiWang XuemeiWu BangguoGeng XinyanLiu ShuangJin LiShi HuijuanTan Yue-QiuRay Pierre FWang LingboYang XiaoyuZhang FengLiu Chunyu