CDKN2B antibody
- Known as:
- CDKN2B (anti-)
- Catalog number:
- orb101817
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- CDKN2B antibody
Related genes to: CDKN2B antibody
- Gene:
- CDKN2B NIH gene
- Name:
- cyclin dependent kinase inhibitor 2B
- Previous symbol:
- -
- Synonyms:
- P15, MTS2, INK4B, TP15, CDK4I, p15INK4b
- Chromosome:
- 9p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-06-14
- Date modifiied:
- 2016-10-05
- Gene:
- CDKN2B-AS1 NIH gene
- Name:
- CDKN2B antisense RNA 1
- Previous symbol:
- CDKN2BAS
- Synonyms:
- ANRIL, RP11-145E5.4, NCRNA00089, p15AS, CDKN2B-AS, PCAT12
- Chromosome:
- 9p21.3
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2008-11-25
- Date modifiied:
- 2017-03-10
Related products to: CDKN2B antibody
Related articles to: CDKN2B antibody
- Fallopian tube carcinoma is one of the most malignant gynecological tumors, with its exact etiology remaining largely unclear. Genetic factors contribute to ~20% of ovarian, fallopian tube, and peritoneal cancers, and gene polymorphisms, including those in non-coding RNAs (ncRNAs) like SNHG17 and CDKN2B-AS1, are linked to gynecologic malignancies. However, research on such polymorphisms in fallopian tube carcinoma is scarce, especially regarding these two genes. Given the correlation between chronic inflammation and malignant tumors (including fallopian tube carcinoma), this study explores the association between SNHG17/CDKN2B-AS1 polymorphisms and susceptibility to salpingitis and high-grade serous fallopian tube carcinoma (HGSC). - Source: PubMed
Publication date: 2025/09/26
Tang LinZhu ZhongyiHu Qian - Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor, with well-documented incidence disparities across ethnic populations: highest in Europeans and lowest in East Asians and Africans. Still, the genetic basis of these differences remains poorly understood. This study assessed whether population-level differences in GBM risk allele frequencies correlate with ethnic disparities in prevalence. We analyzed 673 genome-wide significant GBM candidate loci across five ethnic superpopulations and 26 subpopulations using phased genotype data from the 1000 Genomes Project Phase 3. Population genetic structure was characterized using allele frequencies, heterozygosity, Wright's fixation index, analysis of molecular variance (AMOVA), Nei's genetic distances, and principal coordinate analysis. Risk allele enrichment was visualized via hypergeometric heatmaps, and polygenic risk scores were compared using Kruskal-Wallis and Dunn's tests. Significant interpopulation differentiation was detected across all superpopulation pairs ( < 0.001). European populations had the highest polygenic risk scores, followed by South Asian and Admixed American populations, while East Asians had the lowest. Allele frequencies at key loci, including rs634537 () and rs55705857 (), differed up to tenfold. Finnish populations showed an elevated risk consistent with founder effects. Population genetic structure at GBM risk loci correlates with ethnic incidence disparities, underscoring the need for ancestry-specific approaches in risk modeling and trans-ancestry studies. - Source: PubMed
Publication date: 2026/05/15
Mavrych VolodymyrAlamil MaryamBolgova OlenaDvornyk Volodymyr - Post-stroke cognitive impairment (PSCI) diagnosis primarily relies on scales, which are highly subjective. CDKN2B-AS1 is highly expressed in stroke patients. This study aims to investigate the clinical value and potential regulatory mechanisms of CDKN2B-AS1 in PSCI. This study included 86 patients with PSCI. Cognitive function was assessed using the MoCA scales. A mouse PSCI model was established by treating mice with MCAO using the filament occlusion method. An in vitro PSCI model was constructed by treating HT22 cells with OGD/R. RT-qPCR was used to detect the expression of CDKN2B-AS1, miR-140-3p, Bax, Caspase-3, and Bcl-2 mRNA. ROC analysis evaluated the diagnostic value of CDKN2B-AS1. The Morris water maze assessed spatial learning and memory in mice. Cell proliferation, apoptosis, and inflammatory factors were measured using CCK-8 assay, flow cytometry, and ELISA, respectively. CDKN2B-AS1 is significantly upregulated in PSCI patients, with an AUC of 0.877 in ROC analysis. Its expression level is negatively correlated with MoCA scores. CDKN2B-AS1 has been demonstrated to directly bind and negatively regulate miR-140-3p. Knockdown of CDKN2B-AS1 alleviates OGD/R-induced neuronal apoptosis, inflammatory cytokine (IL-1β, IL-6, TNF-α) release, and oxidative stress levels by elevating miR-140-3p level. It also improves cognitive function in MCAO mice. These protective effects are reversed by miR-140-3p inhibition. Silencing CDKN2B-AS1 may alleviate neuroinflammation and oxidative stress by upregulating miR-140-3p, thereby improving cognitive impairment. CDKN2B-AS1 holds potential as a diagnostic biomarker and therapeutic target for PSCI. - Source: PubMed
Publication date: 2026/05/08
Yan LiminXiao YingDai MingmingQin ShengquanChen Lin - To assess how whole genome sequencing and varying phenotype definitions influence genetic discovery for primary open-angle glaucoma (POAG) in a diverse population. - Source: PubMed
Publication date: 2026/03/22
Aboobakar Inas FCruz Lauren AKinzy Tyler GLuo YuyangNallapaneni SanjanaDo RonVy Thi HaZhao HetinceTran JessicaHysi Pirro GKhawaja Anthony PGharahkhani PuyaPasquale Louis RHauser Michael A Segrè Ayellet VCrawford Dana CWiggs Janey LCooke Bailey Jessica N - WGCNA was used to identify DR-related PANoptosis genes, and the LASSO, SVM-RFE, and Random Forest machine learning models were then employed to identify key PANoptosis-related genes. The lncRNA-miRNA-TLR3 networks were constructed, and the levels of hub lncRNAs, hub miRNAs and TLR3 were measured in a high-glucose cell model. The luciferase reporter assay was employed to validate the interactions between Gm12610 and miR-758-3p, as well as between miR-758-3p and Tlr3. In the GSE102485 and GSE185011 cohort, TLR3 expression was significantly elevated in the DR samples compared to controls. Data from the GSE236627 cohort indicated a marked upregulation of Tlr3 in retinal microglia of db/db mice relative to normal controls. GSEA results showed that AGE-RAGE signaling pathway in diabetic complications and NF-kappa B signaling pathway were enriched and activated in the high-TLR3 expression (H-TLR3) group. Additionally, M2 macrophage infiltration was reduced in this group. Through the ENCORI and TargetScan databases, two ceRNA networks were constructed: C15orf54/CDKN2B-AS1-hsa-miR-758-3p-TLR3 and CDKN2B-AS1-hsa-miR-374b-5p-TLR3. In vitro experiments validated that high glucose-stimulated microglia showed significantly increased levels of Tlr3 and Gm12610 (mouse CDKN2B-AS1), but decreased levels of miR-374b-5p and miR-758-3p compared to the control group. Luciferase assays confirmed direct binding between Gm12610 and miR-758-3p, and between miR-758-3p and Tlr3. Our study identifies TLR3 as a key PANoptosis-related gene in DR, suggesting it potential as a therapeutic target for DR. - Source: PubMed
Publication date: 2026/03/10
Zhao JuanYang MochiShi YushanZhan DongmeiYuan Xiaoyong