CXCL13 antibody
- Known as:
- CXCL13 (anti-)
- Catalog number:
- orb101825
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- CXCL13 antibody
Related genes to: CXCL13 antibody
- Gene:
- CXCL13 NIH gene
- Name:
- C-X-C motif chemokine ligand 13
- Previous symbol:
- SCYB13
- Synonyms:
- BLC, BCA-1, BLR1L, ANGIE, ANGIE2
- Chromosome:
- 4q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-09-05
- Date modifiied:
- 2016-10-05
Related products to: CXCL13 antibody
Related articles to: CXCL13 antibody
- Autoimmune encephalitis (AE) is a major cause of acute and subacute neuropsychiatric syndromes. - Source: PubMed
Publication date: 2026/06/09
Srivastava ArpnaSingh Rajesh KumarBanerjee JyotirmoyA ElavarasiDas AnimeshRamanujam BhargaviParihar JasminePandit Awadh KishorV Y VishnuVibha DeeptiChandra SaratSrivastava M V PadmaTripathi Manjari - Maintenance of gut homeostasis is critical for overall health, as the gut microbiota plays a central role in regulating host metabolism, immune responses, and intestinal barrier integrity. Dysbiosis is closely associated with gastrointestinal disorders and inflammatory diseases, yet the ability of probiotics to preserve microbial resilience under inflammatory stress remains incompletely understood. In this study, we evaluated the protective effects of a multi-strain probiotic formulation, Neuralli-CORE (CORE), using a dextran sulfate sodium (DSS)-induced colitis mouse model. Mice were pre-supplemented with CORE for two weeks prior to DSS exposure. CORE supplementation significantly reduced disease activity index, increased body weight, and partially recovered the colonic histopathological damage in DSS-treated mice. Cytokine profiling showed that CORE reduced circulating PTX2, CHI3L1, CXCL13, and MMP-2 levels, suggesting attenuation of inflammation and tissue remodeling. Microbiota analysis revealed that CORE did not fully prevent DSS-induced dysbiosis but attenuated the early decline in α-diversity and promoted re-emergence of specific microbial taxa, including and , members of the family, which are inversely associated with inflammation. Correlation analysis further linked these taxa to reduced colitis severity. Collectively, CORE attenuates DSS-induced colitis by improving inflammatory resolution, supporting mucosal recovery, and enhancing microbiota resilience. - Source: PubMed
Publication date: 2026/06/04
Deng Fu-ShengCai Yu-LinLin Wei-HsiangWu Chien-ChenTsai Ying-Chieh - To review the evolving shift in peri-implantitis research from traditional mechanical debridement toward host-modulatory and immunopharmacological concepts, focusing on molecular pathogenesis, candidate therapeutic targets, and advanced drug delivery systems requiring further validation. - Source: PubMed
Publication date: 2026/05/26
Chen YongYuan QingCui MingWangGuo ZhuLing - CD4 T cells are indispensable for CD8 T cells-mediated anti-tumor immunity, while little is known about how CD4 T cells coordinate with other cells to promote CD8 T cells activity. In this study, by coupling single-cell RNA sequencing (scRNA-seq) with multiplex immunohistochemistry staining (mIHC), CXCL13-expressing CD4 T cells were explored to recruit CXCR5 B cells to form CXCL13CD4 T cells:: CXCR5 B cells:: CD8 T cells triad, promoting the anti-tumor immunity and heralding a favorable prognosis. A CXCL13-expressing subset of CD4 T cells was identified to be associated with better prognosis and tumor-reactive hallmarks. The further cell types interaction analysis revealed a specific interaction between CXCL13CD4 T cells and CXCR5 B cells in comparison with other cell types. The mIHC verified that an elevated level of CXCR5 B cells infiltration in the proximity of CXCL13CD4 T cells. The subsequent Entropy analysis, which characterizes the colocalization among more than two cell types, was employed to reveal the spatial distribution pattern. The results revealed that CXCL13CD4 T cells and CXCR5 B cells co-localized with cytotoxic CD8 T cells, forming a functional lymphocyte triad, whose existence heralded a better prognosis. Collectively, by integrating scRNA-seq with mIHC, we demonstrated that the recruitment of CXCR5 B cells by neoantigen reacting to CXCL13CD4 T cells through CXCL13-CXCR5 signaling contributed to the lymphocyte triad, leading to an enhanced anti-tumor immunity and heralding a favorable prognosis in non-small-cell lung cancer (NSCLC). - Source: PubMed
Publication date: 2026/06/09
Liu DanpingLuo JiajunGuo WeiMa JunruiYang XiaobaoXia YihanLi PuXu DakangGu Zhidong - Primary CNS lymphoma is typically diagnosed by brain biopsy, a procedure with risks and diagnostic delay. Emerging cerebrospinal fluid (CSF) biomarkers, including the myeloid differentiation primary response 88 (MYD88) L265P mutation in CSF and several chemokines, might improve diagnostic accuracy, but evidence mostly comes from retrospective, non-consecutive cohorts. We aimed to validate the diagnostic utility of CSF biomarkers in patients with suspected primary CNS lymphoma. - Source: PubMed
van Rooij Josephus L MWessels Peter HNiers Johanna MBromberg Jacoline E CGijtenbeek Johanna M Mvan Haastert RickRuven Henk J TMeek BobVerbeek Marcel MSolleveld-Westerink Nienkede Leng Wendy W JMühlebner AngelikaLangerak Anton WBerendsen SharonKnol Edward Fvan Alkemade HannaSeute TatjanaMinnema Monique CNierkens StefanSnijders Tom J