PLAG1 antibody
- Known as:
- PLAG1 (anti-)
- Catalog number:
- orb101852
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- PLAG1 antibody
Related genes to: PLAG1 antibody
- Gene:
- PLAG1 NIH gene
- Name:
- PLAG1 zinc finger
- Previous symbol:
- -
- Synonyms:
- ZNF912
- Chromosome:
- 8q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-02-11
- Date modifiied:
- 2016-11-01
Related products to: PLAG1 antibody
Related articles to: PLAG1 antibody
- Reproductive efficiency in Nellore heifers is fundamental to the profitability and sustainability of beef production in tropical regions, where environmental stress can cause genotype-environment (G×E) interactions that affect fertility. Using 200,258 and 299,885 phenotypic records for heifer early pregnancy (HP) and heifer rebreeding (HR), respectively, we investigated the genetic basis of reproductive plasticity via single-step genomic reaction norms across a continuous environmental gradient (EG) defined from yearling weight records as a proxy for environmental quality. Genomic analyses included 22,556 animals (21,456 females and 1,100 sires) with genotypes imputed to 409,617 single-nucleotide polymorphisms (SNPs). We then performed genome-wide association analyses of the reaction norm intercept (genetic merit) and slope (environmental sensitivity), followed by multi-trait summary analyses and Bayesian fine-mapping of significant loci using imputed whole-genome sequence variants within ±100 kb windows around lead SNPs. - Source: PubMed
Publication date: 2026/06/08
Mota Lucio F MArikawa Leonardo MSantos Daniel J ABrito Luiz FFonseca Larissa F SOliveira Henrique NAlbuquerque Lucia G - Sporadic cardiac myxoma (SCM) is the most common primary tumor of the heart; however, its molecular pathogenesis remains poorly understood. Unlike the familial forms associated with the Carney complex (CNC), SCM lacks well-defined genetic alterations. Recognizing the established role of pleomorphic adenoma gene 1 (PLAG1) rearrangements in developmental syndromes with cardiac anomalies and in neoplasms characterized by prominent myxoid stroma, we investigated whether similar genetic events occur in SCM. In parallel, we evaluated MYC amplification, considering its known association with the malignant transformation in the mesenchymal tumors. - Source: PubMed
Publication date: 2026/05/20
Maffini FaustoLepanto DanielaPisa EleonoraDe Camilli EisaCatto ValentinaZanetti ChiaraPessina SimonaCarbucicchio CorradoPagni FabioFusco Nicola - This study aimed to identify a 21 bp insertion/deletion mutation in the gene (intron 2) and a single nucleotide polymorphism (c.48333G > A) in the gene (exon 3), and evaluate their association with growth traits in mature Madura and Bali cattle. A total of 219 animals (156 Madura and 73 Bali cattle) were assessed for body weight (BW) and four body measurements: Heart girth (HG), body length (BL), hip height (HH), and withers height (WH). Genotyping was performed using PCR and PCR-RFLP techniques. Both genes were polymorphic, with high PIC values (> 0.30). The gene polymorphism was significantly associated with HH in Bali cattle, while the gene showed significant associations with BW in both breeds. These findings suggest that (c.48333G > A) is a promising genetic marker for BW in Indonesian tropical cattle. - Source: PubMed
Publication date: 2026/03/16
Hartati HartatiPutra Widya Pintaka BayuMariyono MariyonoLuthfi MuhammadAffandhy LukmanRobba Dewi KhosiyaHandiwirawan EkoIrmawanti SulistiyoningtiyasAryogi AryogiNoor Susan MaphilindawatiRomjali EndangSeptian Wike Andre - Myxoid inflammatory myofibroblastic sarcoma (MIMS) is a recently described aggressive sarcoma with deceptively bland spindled cells with a myofibroblastic phenotype and myxoid stroma. These tumors are negative for ALK gene rearrangements, but have been shown to harbor gene fusions involving PDGFRA/B, JAK1, and PML and/or mutations involving KRAS. Only one uterine case has been previously reported. Here we report the second case of uterine MIMS. This tumor arose in a 40-yr-old woman patient and showed a conspicuously whorled architecture with myxoid stroma and so-called organoid aggregates. By immunohistochemistry, the tumor was positive for CD10, estrogen receptor (ER), and progesterone receptor (PR) with focal smooth muscle actin expression and no staining for ALK, desmin, h-caldesmon, HMB-45, or cathepsin-K. Next-generation sequencing analysis revealed the presence of 2 pathogenic mutations in KRAS, as well as pathogenic mutations in RAD51B and LATS1. No gene fusions in PDGFRA/B, JAK1, PML, ALK, ROS1, PLAG1, or any other gene were identified by whole transcriptomic RNA sequencing. Given its deceptively bland appearance and its propensity, at least in the uterus, to express both CD10 and ER with only focal SMA expression, MIMS can be mistaken for an endometrial stromal tumor, an ALK and ROS1-negative uterine inflammatory myofibroblastic tumor, or other cytologically bland fusion-driven uterine mesenchymal neoplasms. - Source: PubMed
Publication date: 2026/05/27
Xu JinKushner DavidWeisman Paul S - Lipoblastomas are rare, benign tumors arising from embryonic white fatty precursor cells that continue to proliferate in the postnatal period. We present a case of a minimally differentiated lipoblastoma with myxoid features. Our patient was an 18-month-old female with a painless solid tumefaction in the middle third of the right leg. Histopathologically, the nodular tumor mass consisted of lipoblasts embedded in a myxoid stroma. Immunohistochemistry showed strong diffuse positivity for S100, CD34, CD56, NSE and rare Ki67+ cells. FOXO1 polyploidy was detected in 30% of cells by FISH. Using target RNA sequencing, we detected a fusion gene showing that the first exons of were fused to either exon 2 or exon 3 of . Our case demonstrates that due to the histomorphologic overlaps, the molecular diagnostics can be essential for the confirmation of the diagnosis of lipoblastoma. - Source: PubMed
Publication date: 2026/05/12
Cvetković DanijelaJanković Marina GazdićKovačević Marina MiletićHamzagić Amra RamovićUrošević IrenaRosić VesnaLjujić Biljana