PLAG1 antibody
- Known as:
- PLAG1 (anti-)
- Catalog number:
- orb101852
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- PLAG1 antibody
Related genes to: PLAG1 antibody
- Gene:
- PLAG1 NIH gene
- Name:
- PLAG1 zinc finger
- Previous symbol:
- -
- Synonyms:
- ZNF912
- Chromosome:
- 8q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-02-11
- Date modifiied:
- 2016-11-01
Related products to: PLAG1 antibody
Related articles to: PLAG1 antibody
- The zinc finger transcription factor PLAG1 has been implicated in multiple diverse cellular processes, yet its role in the onset of vertebrate neurodevelopment and behaviour remains largely unexplored. Notably, dysregulation of PLAG1 has been associated with Silver-Russell syndrome (SRS) in humans, a growth disorder often presenting with neurodevelopmental delay and craniofacial abnormalities. Here, we investigate the function of plag1 in zebrafish embryogenesis, focusing on behavioural phenotypes, neural development and craniofacial morphogenesis, as a potential novel model of SRS. Using antisense morpholino-mediated knockdown, we assessed the impact of plag1 loss on brain architecture, motor neuron development, craniofacial patterning and stimulus-evoked behavioural responses. While plag1-deficient embryos displayed pronounced locomotor defects when housed in groups, these phenotypes were not recapitulated under isolated, individual tracking conditions, suggesting a role for plag1 in modulating specific behavioural outputs. Morphological analyses revealed no overt disruptions to gross brain structure or primary motor neuron patterning. However, quantitation of craniofacial skeleton formation identified subtle abnormalities in jaw and cranial cartilage development, consistent with features observed in SRS. Furthermore, plag1 morphants exhibited significantly altered responses to sensory stimuli, implicating plag1 in the regulation of sensorimotor integration during early development. Collectively, these findings uncover a novel role for plag1 in early neurobehavioural modulation and craniofacial patterning, phenocopying multiple features of SRS, and highlight the importance of environmental and social context in the phenotypic interpretation of neurodevelopmental gene function. - Source: PubMed
Gasperoni Jemma GFuller Jarrad NLewis April LJohnson Travis KDe Groef BertDworkin Sebastian - Lipoblastoma is a benign tumor of adipocytic differentiation originating from embryonal white fat that is commonly described in young children, with rare cases arising in adults. gene (8q11-13) rearrangement is a characteristic feature of lipoblastoma. However, gene rearrangement has also been reported in a few cases of lipoblastoma, with the gene fusion partners reported thus far being , and genes. Herein, we report an -rearranged lipoblastoma arising in the chin of a 51-year-old female with a novel gene fusion partner, the gene, that has not been previously described in lipoblastomas. Our case adds to the growing pool of gene fusion partners of -rearranged lipoblastomas and expands the molecular spectrum of lipoblastomas in general beyond the previously described gene rearrangements, thereby suggesting that lipoblastomas may be more molecularly heterogeneous than previously appreciated. - Source: PubMed
Publication date: 2026/08/27
Naous RanaVictor Aaron - GPNMB is a lysosomal transmembrane protein that has emerged as a diagnostic marker for tumours driven by the microphthalmia-associated transcription factor family (TFE3 and TFEB) and mTOR pathway activation. Diffuse, moderate-to-strong GPNMB positivity has been proposed as a surrogate marker for both translocation-driven and mTOR pathway-activated neoplasms, including PEComas. This study investigated the diagnostic utility of GPNMB immunohistochemistry in differentiating uterine PEComas from common morphological mimics among uterine mesenchymal tumours. - Source: PubMed
Publication date: 2026/09/25
Skopal JosefŠvajdler MariánPtáková NikolaVaněček TomášMichal MichaelGettse PolinaPresl JiříKormunda StanislavNovotný JanDundr PavelMichal MichalMichalová Květoslava - Myoepithelial carcinoma (MECA) represents a rare malignant neoplasm accounting for less than 2% of all salivary tumors, with recurrent PLAG1 rearrangements comprising its predominant underlying molecular aberration. - Source: PubMed
Publication date: 2026/09/22
Argyris Prokopios PTjota Melissa YLingen Mark WCipriani Nicole A - PLAG1 immunohistochemistry and FISH were essential for diagnosis of extra-uterine myxoid leiomyosarcoma and should be considered in myxoid intra-abdominal tumors, especially in patients with previous uterine surgery. - Source: PubMed
Publication date: 2026/09/16
Hsieh Cheng-EnWu Po-HsuanSu Chang-WeiMa Yu-ChunHuang Hsuan-Ying