PLAG1 antibody
- Known as:
- PLAG1 (anti-)
- Catalog number:
- orb101852
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- PLAG1 antibody
Related genes to: PLAG1 antibody
- Gene:
- PLAG1 NIH gene
- Name:
- PLAG1 zinc finger
- Previous symbol:
- -
- Synonyms:
- ZNF912
- Chromosome:
- 8q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-02-11
- Date modifiied:
- 2016-11-01
Related products to: PLAG1 antibody
Related articles to: PLAG1 antibody
- Pleomorphic adenoma is a common benign minor salivary gland tumor of the oral cavity, with the palate being the most common site. Considering the local anatomy, profuse vascularity, and proximity to vital structures, diagnosis and surgical management present specific challenges. The lack of a true capsule in minor gland lesions, the associated risk of recurrence, and potential for malignant transformation are key factors to consider when formulating a treatment plan. This case report highlights early diagnosis and management, and reviews the literature on management protocols and the importance of long-term follow-up in such cases. - Source: PubMed
Publication date: 2026/09/14
Singh Anup KYadav Rekha CPandey Satyanarayan - Pleomorphic adenoma is the most common benign salivary gland tumor and most frequently arises in the parotid gland. Although benign, it can recur and may undergo malignant transformation, underscoring the need for experimental models that preserve native tissue features over time. In this study, fresh tumor tissue from six patients with primary histologically benign pleomorphic adenoma was divided into fragments of approximately 3 × 3 mm in surface dimensions and approximately 3 mm in thickness and maintained in a patient-derived three-dimensional organotypic co-culture for up to 21 days. The primary longitudinal analysis compared baseline tissue with matched fragments harvested at days 14 and 21. Histology and immunohistochemistry were assessed in three randomly selected high-power fields within morphologically viable, tumor-containing regions; necrotic or degenerative areas were excluded. Ki-67-positive cell nuclei remained within the predefined low category at all retained time points. PLAG1 positivity was retained in all cases but was more variable by day 21, while epithelial and myoepithelial-associated markers showed marker- and case-dependent patterns. CD45-positive cells remained detectable in sampled viable compartments, whereas SSTR2 was commonly reduced after baseline. These findings support the use of the 3D-OTC platform for longitudinal histomorphologic and selected biomarker assessment within surviving viable tissue compartments. Because whole-fragment necrosis and diffusion of oxygen, nutrients, or test compounds were not quantified, the present data do not establish uniform full-thickness viability or validate the platform for therapeutic-response testing. - Source: PubMed
Publication date: 2026/09/13
Hoch Cosima CWeiser TobiasStögbauer FabianJohnson FelixMulthoff GabrieleBashiri Dezfouli AliWollenberg Barbara - Nasopharyngeal carcinoma (NPC) is a multifactorial disease driven by both genetic and environmental factors. The neurogenic locus notch homolog 1 (NOTCH1) gene has dual oncogenic and tumor-suppressive effects that depend on the cellular context. An intronic single nucleotide polymorphism (SNP) in NOTCH1, rs3124599, has been linked to various diseases. However, its involvement in NPC remains unknown. This study aims to explore the regulatory and susceptibility effects of rs3124599 on NPC. - Source: PubMed
Publication date: 2026/08/31
Sultan Mujeeb ARomdhoni Achmad ChusnuWungu Citrawati Dyah KenconoPurwono Priyo Budi - Skeletal muscle satellite cells (MuSCs) are essential for muscle growth and development, but their regulatory mechanisms remain unclear. This study aimed to characterize the expression pattern of pleomorphic adenoma gene 1 (), determine its effects on MuSC proliferation and differentiation, and explore its potential regulatory mechanisms through integrated transcriptomic and ceRNA analyses in Sujiang pig MuSCs. Results showed that was widely expressed in multiple porcine tissues and was significantly upregulated during MuSC differentiation. overexpression promoted MuSC proliferation and differentiation, whereas knockdown produced the opposite effects. Whole-transcriptome sequencing following knockdown identified 432 differentially expressed mRNAs, 70 miRNAs, 163 lncRNAs, and 150 circRNAs. Enrichment analysis revealed that differentially expressed mRNAs were mainly associated with cell cycle regulation, DNA replication, and the p53 signaling pathway. Western blot analysis further showed that knockdown reduced CDK1 and PCNA protein levels. ceRNA network analysis revealed potential regulatory associations among differentially expressed lncRNAs, circRNAs, miRNAs, and mRNAs, and the expression changes in selected differentially expressed RNAs were further validated by qRT-PCR. Collectively, these findings indicate that promotes MuSC proliferation and differentiation and may be associated with cell cycle-related gene expression changes and potential non-coding RNA regulatory networks in porcine MuSCs. - Source: PubMed
Publication date: 2026/07/24
Zhang LiLi HongxiaDou AnqiFu ChangyaoSun SuyiCao ShinuoZhou QingkangMiao WeiZhou MoWang WenhaoXu JialongZhu Shanyuan - The impact of structural variants on gene regulation and complex traits in pigs remains poorly understood. Here, we present a resource comprising 60 long-read sequencing and 2445 high-quality short-read sequencing samples from 120 pig breeds/populations worldwide. These samples include 293 high-depth short-read sequencing samples and three long-read samples generated in this study. Integrating two graph-based genotyping approaches, we construct a structural variant map encompassing 158,288 deletions, 137,493 insertions, 660 inversions, and 10,063 duplications. We perform eQTL mapping in liver, skeletal muscle, backfat, and intramuscular fat tissues from an F6 hybrid pig family, finding that 49.01% of expressed genes are significantly associated with cis-region structural variants. We further explore the contribution of structural variants to domestication and population differentiation. We find a 53 bp insertion on chromosome 11 that significantly down-regulates GPC6 expression in liver tissue, potentially contributing to adaptive selection in northern Chinese pig populations. Additionally, FST analyses between miniature and commercial pig breeds identify candidate structural variant loci associated with body size. We next integrate results from structural variant-eQTL and GWAS to find a 50 bp deletion at chr4:75,613,295 that significantly reduces PLAG1 expression in skeletal muscle tissue and is associated with body weight at 240 days of age. - Source: PubMed
Publication date: 2026/07/27
Wu ZhongziGui LuHu JianchaoChen XiaoyunZhang ZhiyanGao JunLiu WeiweiHuang Lusheng