MMP14 antibody
- Known as:
- MMP14 (anti-)
- Catalog number:
- orb36366
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- MMP14 antibody
Related genes to: MMP14 antibody
- Gene:
- MMP14 NIH gene
- Name:
- matrix metallopeptidase 14
- Previous symbol:
- -
- Synonyms:
- MT1-MMP
- Chromosome:
- 14q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-11-20
- Date modifiied:
- 2016-10-05
Related products to: MMP14 antibody
Related articles to: MMP14 antibody
- Hypertensive retinopathy is a microvascular complication caused by systemic hypertension and can lead to severe visual impairment. At present, the molecular mechanisms of this disease remain incompletely understood, particularly the global expression profiles and regulatory networks of non-coding RNA (ncRNA). This study aims to comprehensively analyze the genome-wide differential expression profiles of messenger RNA (mRNA), microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA) in retinal tissues from a spontaneously hypertensive rat (SHR) model of hypertensive retinopathy, and to observe transcriptomic changes after treatment with the calcium channel blocker lacidipine, thereby revealing their potential roles in disease pathogenesis and identifying possible therapeutic targets. - Source: PubMed
Shi WenXiao ShiyuanBu BingHuang TianxinJiang YiranJiang Wenmin - Alcohol consumption has been a risk factor for more than 200 diseases, including esophageal cancer. Cell communication network 1 (CCN1), a matricellular protein, is highly expressed in esophageal squamous cell carcinoma (ESCC) but is barely detectable in esophageal adenocarcinoma (EAC). Alcohol consumption has been identified as a major contributor to ESCC development, but its role in EAC is uncertain. This study examines the impact of acute (30 min) or prolonged (12 h) alcohol exposure (5, 100, and 500 mM) on CCN1 expression and function in esophageal epithelial cells, including normal (HEEC), ESCC (KYSE150 and KYSE410), and EAC (OE19 and OE33), in association with the activity of MMP2, MMP9, and MMP14. It was found that alcohol exposure promoted CCN1 expression in both normal and tumor cells but induced CCN1 cleavage exclusively in EAC cells, generating an 18-kDa fragment that promotes tumor growth. MMP9, which was active only in EAC cells, was found to mediate this cleavage. Forced activation of MMP9 in either normal or ESCC cells improved cell viability, whereas inhibition of MMP9 in EAC cells attenuated cell survival. Taken together, alcohol exposure promotes MMP9-mediated CCN1 cleavage in EAC, converting CCN1 from a pro-death to a pro-survival factor for EAC. This makes alcohol consumption a risk factor not only for ESCC development but also for EAC progression. A preprint can be found at d197for5662m48.cloudfront.net. - Source: PubMed
Publication date: 2026/08/05
Aladan WulaChi BaoxinChang ZhihengWang MizhuDang TongMeng XianmeiChai Jianyuan - Idiopathic pulmonary fibrosis(IPF) is a fatal interstitial lung disease with limited clinical therapeutic options. Traditional Chinese medicine formulas, characterized by multi-component, multi-target, and holistic regulatory properties, have shown unique potential in the prevention and treatment of IPF. Yangyin Yifei Tongluo Pills(YF) is a TCM formula with demonstrated clinical efficacy. However, its modern pharmacological mechanism against IPF remains to be systematically elucidated. In this study, ultra-high-performance liquid chromatography coupled with quadrupole-Orbitrap high-resolution mass spectrometry(UHPLC-Q Exactive Orbitrap-HRMS) was employed to identify the chemical constituents of YF. A total of 76 potential bioactive compounds were characterized, including flavonoids, phenylpropanoids and other chemicals. By integrating network pharmacology and bioinformatics analyses, drug-related targets, IPF-associated targets, differentially expressed genes, and WGCNA-derived key module genes were intersected, yielding 15 potential targets. Based on a systematic evaluation using nine machine learning algorithms, arginase 1(ARG1) and matrix metalloproteinase 14(MMP14) were identified as key core targets. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analyses indicated that these targets were mainly involved in inflammatory regulation, signal transduction, and extracellular matrix(ECM) remodeling, with significant enrichment in key signaling pathways such as the TNF signaling pathway. Immune microenvironment analysis revealed that the expression levels of ARG1 and MMP14 were closely associated with immune and stromal cell infiltration characteristics. Molecular docking demonstrated favorable binding affinities between ARG1/MMP14 and several core components, including miltirone, peimine, cryptotanshinone, and sec-O-glucosylhamaudol, while molecular dynamics simulations further confirmed the conformational stability of miltirone and sec-O-glucosylhamaudol, as core potential bioactive components, with the targets under dynamic conditions. Collectively, these findings suggest that YF may exert anti-IPF effects by targeting ARG1 and MMP14 through its core potential bioactive components, synergistically modulating key processes including the immune microenvironment, fibroblast activation, and extracellular matrix remodeling. By integrating LC-MS, bioinformatics, machine learning, immune infiltration analysis, molecular docking, and molecular dynamics simulation, this study systematically elucidates the multi-component and multi-target mechanisms of YF, providing new insights and a foundation for the intervention and treatment of IPF and the mechanistic study of TCM formulas. - Source: PubMed
Wen Ke-HanZhao QiGuo Ao-JieWu Zhi-ChaoXia Xiao-LinChen Le-leXu YongXiao Na - The aim was to determine the transcriptomic features of tumor and stromal cells in direct contact within tumor nodules in luminal and triple-negative breast cancer. - Source: PubMed
Publication date: 2026/07/29
Kalinchuk Anna YuPatskan Ivan AGrigorieva Evgeniya STashireva Liubov A - Available data indicate that the development of refractory schizophrenia may result from neuroinflammation, dysregulation of neurotrophins and metalloproteinases (MMPs), oxidative stress (OS), and hormonal imbalance. Electroconvulsive therapy (ECT) is an effective therapeutic option for drug resistance, but its impact on brain-derived neurotrophic factor (BDNF) and MMPs remains underinvestigated. This study evaluates the influence of ECT on serum BDNF, MMPs (MMP-7, MMP-9, MMP-14), and tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2, TIMP-3) in patients with treatment-resistant schizophrenia (TRS). Another goal of this study is an assessment of the relationships between these biomarkers and the intensity of schizophrenia symptoms. Serum concentrations of the aforementioned biomarkers were measured prior to and after ECT in eight patients and 13 healthy controls. The severity of schizophrenia symptoms was evaluated with the Positive and Negative Syndrome Scale (PANSS). Bayesian analysis comparing pre-ECT serum concentrations of BDNF, MMPs, and their inhibitors in TRS patients with a control group showed a significant difference only for MMP-9. Furthermore, convincing evidence of a correlation between MMP-9 and MMP-14 was found in TRS patients. Although the ECT therapy did not result in changes in the serum concentrations of the studied biomarkers, substantial improvement in schizophrenia symptoms on the PANSS was observed. : No significant biomarker changes (post- versus pre-treatment) were detected in this small exploratory cohort. Whether these biomarkers are involved in neuroinflammation (as possible contributors to the development of TRS) remains an open question, and therefore, further research on biomarkers in cerebrospinal fluid (CSF) may be suggested. - Source: PubMed
Publication date: 2026/07/08
Szota Anna MariaĆwiklińska-Jurkowska MałgorzataRadajewska IzabelaLis KingaGrudzka PrzemysławDróżdż Wiktor