SASH1 antibody
- Known as:
- SASH1 (anti-)
- Catalog number:
- orb29537
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- SASH1 antibody
Related genes to: SASH1 antibody
- Gene:
- SASH1 NIH gene
- Name:
- SAM and SH3 domain containing 1
- Previous symbol:
- -
- Synonyms:
- KIAA0790, dJ323M4.1, SH3D6A
- Chromosome:
- 6q24.3-q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-27
- Date modifiied:
- 2018-02-13
Related products to: SASH1 antibody
Related articles to: SASH1 antibody
- Preeclampsia (PE), a pregnancy-specific pathological condition, has shown a growing incidence over recent decades. Disulfidptosis is a newly discovered mode of programmed cell death that differs from traditional cell death pathways in its molecular mechanisms. Numerous studies have reported the association between disulfidptosis and various diseases; however, the role of disulfidptosis in the pathogenesis of PE remains unknown. - Source: PubMed
Publication date: 2026/06/20
Chen XiangbeiChen XuemeiZhao BoenLv PingPang DongLai Lichuan - Meningiomas are the most common intracranial tumors. DNA methylation analysis in benign and aggressive meningiomas showed decreased methylation and overexpression of hsa-miR-21-5p in atypical and anaplastic tumors. Transcriptomic analysis of distinct WHO grade meningiomas showed multiple predicted hsa-miR-21-5p target genes as differentially expressed. They were mainly related to processes of intercellular and intracellular signaling. Intercellular communication in meningioma was investigated using the deposited scRNA-seq dataset and deconvolution of our RNA-seq data. We found WHO grade-related differences in the microenvironment including inverse correlation between the count of border-associated macrophages (BAM) and the level of hsa-miR-21-5p. Single-cell transcriptomics suggests the role of interleukin 6 in direct communication between tumor cells and BAMs. and are predicted targets of hsa-miR-21-5p downregulated in atypical/anaplastic meningiomas. IL6R downregulation was also confirmed by immunohistochemistry. Hsa-miR-21-5p enhanced proliferation and viability of KT21-MG1 meningioma cells and showed a regulatory effect on , and other predicted target genes , , , and by interacting with 3'UTRs. DNA hypomethylation-related overexpression of hsa-miR-21-5p contributes to aggressive meningioma growth by interaction with multiple target genes, and probably affects microenvironment communication between meningioma cells and BAMs by lowering the IL6R level in tumor tissue. - Source: PubMed
Publication date: 2026/05/15
Kober PaulinaBaluszek SzymonMossakowska Beata JoannaMyśliwy IzabellaTsegaye BiniyamOziębło ArturMandat TomaszBujko Mateusz - Laryngeal dysplasia and Reinke's edema (RE) are common vocal fold lesions associated with smoking. While the former is cancer prone, most cases of the latter do not undergo malignant transformation. Therefore, we proposed identifying biomarkers of smoking-induced benign-malignant transformation of vocal fold lesions. - Source: PubMed
Publication date: 2025/05/19
Liu Yun-YiZhuang Pei-Yun - Sterile alpha motif and SH3 domain-containing 1 (SASH1), a tumor suppressor, is involved in multiple biological processes in cancer cells. However, the potential role and mechanism of SASH1 in regulating glucose metabolism of gastric cancer (GC) remains unknown. SASH1 and Yes-associated protein 1 (YAP1) expressions in GC tissues were investigated based on The Cancer Genome Atlas (TCGA) database. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blot were used to analyze the expressions of the SASH1 and YAP1 in GC tissues and cell lines. Cell Counting kit-8 (CCK-8) and wound healing assays were conducted to measure the proliferation, migration and drug resistance. Commercial kits were used to assess the uptake of glucose and the productions of lactate and adenosine triphosphate (ATP). Extracellular acidification rate was measured using a microphysiometer. Co-Immunoprecipitation assay was performed to confirm the binding between SASH1 and YAP1. The results showed that SASH1 was decreased in GC tissues and cell lines. Overexpressing SASH1 inhibited the proliferation and migration, as well as decreased the drug resistance of GC cells. SASH1 decreased the uptake of glucose and extracellular acidification rate, as well as inhibited the productions of lactate and ATP. The expressions of glycolysis-related proteins were downregulated in GC cells with high SASH1 expression. Mechanistically, SASH1 regulated glucose metabolism reprogramming through promoting the phosphorylation and degradation of YAP1. Increased YAP1 reversed tumor-inhibiting effects of SASH1. In conclusion, SASH1 affected the phosphorylation and degradation of YAP1, thus suppressing the glycolysis and malignant biological behaviors of GC cells. The above findings revealed that SASH1 may be one of the molecular targets for GC therapy. - Source: PubMed
Publication date: 2026/03/31
Qiu TingGao ShujuanZhang LingjuanYan ChunyingNiu LuLiu GuishengWang PingLyu Yifei - Sorafenib resistance remains a major barrier to effective therapy in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). - Source: PubMed
Publication date: 2026/03/23
Han KyuyoungJwa Eun-KyoungHa SuhyeonKim JiyeLee RyunjinLee EunkyeongKang SeoonKim Hye OkKwon HyunheeJung Dong-HwanYoon Young-InSong Gi-WonPark Gil-ChunKim Tae WonNamgoon Jung-ManHwang ShinTak EunyoungLee Sung-Gyu