ACTH 18-39 antibody
- Known as:
- ACTH 18-39 (anti-)
- Catalog number:
- orb10035
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- ACTH 18-39 antibody
Related genes to: ACTH 18-39 antibody
- Gene:
- AGBL5 NIH gene
- Name:
- ATP/GTP binding protein like 5
- Previous symbol:
- -
- Synonyms:
- FLJ21839, CCP5
- Chromosome:
- 2p23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2007-03-27
- Date modifiied:
- 2016-06-21
- Gene:
- MC2R NIH gene
- Name:
- melanocortin 2 receptor
- Previous symbol:
- -
- Synonyms:
- ACTHR
- Chromosome:
- 18p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-07-20
- Date modifiied:
- 2016-02-01
- Gene:
- POMC NIH gene
- Name:
- proopiomelanocortin
- Previous symbol:
- -
- Synonyms:
- MSH, POC, CLIP, ACTH, NPP, LPH
- Chromosome:
- 2p23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
- Gene:
- RNPC3 NIH gene
- Name:
- RNA binding region (RNP1, RRM) containing 3
- Previous symbol:
- -
- Synonyms:
- KIAA1839, FLJ20008, RBM40, SNRNP65
- Chromosome:
- 1p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-09-17
- Date modifiied:
- 2015-11-05
Related products to: ACTH 18-39 antibody
Related articles to: ACTH 18-39 antibody
- Combined modulation of the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-adrenal (HPA) axes is known to play a critical role in maintaining physiological stability in response to stress. In this study, stress induced modulation of these axes was examined using 20 pigs/treatment either weaned (WN), weaned with feed/water restriction 9 h (FR), transported 9 h (TRANS), or remaining with sow (SOS) and euthanized at 32 or 56 h post-weaning. Serum cortisol, thyroxine (T4), and triiodothyronine (T3) were measured before weaning and after 24, 32, and 56 h with no difference in cortisol concentrations among treatments at any timepoint. However, both T3 and T4 decreased post-weaning in FR, TRANS, and WN compared to SOS. Expression of 23 genes of interest was evaluated across the hypothalamus, pituitary, thyroid, and adrenal glands of TRANS and SOS pigs at 56 h to understand the underlying mechanism. TSHB, DIO3, and POMC expression was decreased in the pituitary while DIO3 in the thyroid was increased, with upregulation in MC2R also observed. Collectively, these results suggest acute stressors in swine can induce type I allostasis within the HPT axis and modulate sensitivity within the HPA. - Source: PubMed
Walpole Isabel BSmith Alyssa ARudy Kaylyn GJeon DayeonRadcliffe J ScottPasternak J Alex - Organophosphate flame retardants (OPFRs) are ubiquitous flame-retardant additives with endocrine-disrupting properties. Despite increasing evidence that OPFRs affect neurodevelopment, their effects on the neuroendocrine stress response remain poorly understood. To examine their long-term effect on stress regulation, we treated pregnant C57Bl/6J dams to a mixture of tris(1,3-dichloro-2-propyl) phosphate (TDCPP), triphenyl phosphate (TPP), and tricresyl phosphate (TCP; 1 mg/kg each) from gestational day (GD) 7 through postnatal day (PND) 14. Adult offspring (age 8-9 weeks) were then challenged with acute stressors, including 1-hour restraint or a 6-day acute variable stress (AVS) paradigm. Perinatal OPFR exposure produced persistent, sex-specific alterations in the hypothalamic-pituitary-adrenal (HPA) axis and stress-related neurocircuitry. Following 1-hour restraint, OPFR-treated females showed heightened serum corticosterone. In addition, gene expression analysis revealed sex-dependent disruptions in key stress-regulatory pathways after OPFR treatment and 1-hour restraint in the hypothalamus (Crhr1, Crhr2, Ptpn5) and pituitary (Crhr1, Pomc, Nr3c1). Females demonstrated more differences in adrenal gene expression related to steroidogenesis (Mc2r, Cyp11b2) and catecholamine biosynthesis (Dbh, Pnmt), with OPFR-treated groups having blunted responses. OPFR AVS females displayed reduced corticosterone and Crh messenger RNA in the hypothalamus, and downregulated Pacap/Pac1r expression in the bed nucleus of the stria terminalis (BNST), accompanied by increased behavioral avoidance and immobility. In males, OPFR exposure led to increased BNST Pacap and Pac1r expression, along with hyperactivity and avoidance behaviors. Together, these findings demonstrate that early-life OPFR exposure induces lasting, sex-specific dysregulation of the HPA axis and associated stress circuits, highlighting OPFRs as developmental neuroendocrine disruptors with implications for mood- and stress-related disorders. - Source: PubMed
Rojas Catherine MDeLucca JuliaBrown Caylee AYasrebi AliChiou SavannahBello Nicholas TRoepke Troy A - Glaucoma is a chronic optic neuropathy characterized by progressive vision loss. A previous study from our group showed that glaucoma-induced retinal degeneration disrupts photic signaling to the suprachiasmatic nucleus (SCN), altering the molecular components of the central circadian clock. Through its hypothalamic projections, the SCN entrains the hypothalamic-pituitary-adrenal (HPA) axis and drives the rhythmic secretion of corticosterone. In this study, we investigated whether central circadian clock disruption in glaucoma impacts the HPA axis and its downstream physiological rhythms. We analyzed the temporal profiles of key genes controlling the HPA axis in mice with glaucoma. The Crh gene expression was reduced in the paraventricular nucleus, while Crh-r1 exhibited a 10-h phase delay in the pituitary in response to glaucoma. Additionally, Pomc in the pituitary and Mc2r in the adrenal lost rhythmicity. The modulation of the daily rhythms of these key genes was associated with alterations in the diurnal rhythms of clock genes in the PVN, pituitary and adrenal gland. Glaucoma-induced phase shifts and amplitude alterations in the rhythmic expression of Per1, Per2, Nr1d1, and Bmal1 in the pituitary and adrenal gland, resulted in a temporal misalignment between the pituitary and adrenal rhythms. These molecular changes were associated with reduced corticosterone amplitude, suggesting impaired communication between central and peripheral clocks. Together, these findings demonstrate that glaucoma alters the temporal coordination of the HPA axis, highlighting how retinal dysfunction can propagate beyond the visual system to disturb systemic circadian and neuroendocrine regulation. - Source: PubMed
Barsanele Pietra Souzada Silva Juliano JeffersonCortes Bryan Fellipe da Silvade Oliveira Furtado Eliz MariaCipolla-Neto Joséde Assis Leonardo Vinícius MonteiroPoletini Maristela OliveiraMoraes Maria Nathália - Obesity and Alzheimer’s disease (AD) are epidemiologically associated. The locus coeruleus (LC)—the brain’s primary and most significant source of norepinephrine—is one of the earliest sites of neurodegeneration in AD. The LC participates in feeding behavior through connections with the hypothalamus. The cellular composition of the LC has been characterized at single-cell resolution. However, the constituent cellular signatures of genes related to energy homeostasis—such as the melanocortin pathway genes—in the LC are unclear. We performed single-nucleus RNA sequencing and spatial transcriptomics (Visium) in the human LC, and HiPlex RNAscope in the LC of mice. The melanocortin pathway gene MRAP2 was expressed in the majority of DBH neurons across the LC. Mrap2 was also co-expressed with AD-associated genes such as App, Psen1, Psen2, and Sorl1. More than 20% of Dbh neurons in the LC were positive for Mrap2, App, Psen1, and Psen2. Mrap2 is expressed in the central nervous system and modulates the trafficking and signaling of all five G-protein coupled receptors (GPCRs) of the melanocortin receptor family: Mc1r, Mc2r, Mc3r, Mc4r, and Mc5r. In mice, among the melanocortin receptors, Mc5r showed the highest co-expression with Mrap2, accounting for 17.9% of Mrap2-positive cells, followed by Mc2r with 10.9% of Mrap2-positive cells. Mc1r, Mc3r, and Mc4r showed very limited co-expression with Mrap2. Our study reveals that many Mrap2-positive cells do not express any melanocortin receptor genes, warranting future studies into metabolically relevant GPCRs downstream of MRAP2 in the LC. In summary, our study characterizes melanocortin molecular substrates in the human and mouse LC and highlights MRAP2 as a potential link between pathways of energy homeostasis and neurodegeneration. - Source: PubMed
Publication date: 2026/04/04
Basak AlishaErol Fahrünisa Meryem BetülDe Rosa Maria CaterinaDong ZhangjiOgbolu VictorGlover Hannah JRausch RickHargus GunnarCreus-Muncunill JordiBuchanan HeatherBai YuSu QiChang BettyAdler ChristinaFlaherty DelaneyCiener BenjaminXiao HarrisonReddy HasiniAime-Wilson PascalineReitz ChristianeSleeman Mark WAltarejos Judith YLeibel Rudolph LQiang Liang OscarTeich Andrew FDoege Claudia A - The hypothalamic-pituitary-interrenal (HPI) axis mediates stress responses in fish. Previous work showed that dietary supplementation with B vitamins attenuated cortisol response to acute stress, whereas dietary genistein produced high basal levels of cortisol and altered stress responsiveness. In the present study, we investigated the expression of key genes of the HPI axis and selected hepatic targets to better characterize these responses. Cortisol was correlated with nr3c1 expression in the pituitary of control fish. Conversely, B vitamins supplementation was associated with changes in the relationship between plasma cortisol levels and nr3c1 expression across tissues, including higher basal higher basal expression expression in the head kidney. In parallel, lower hepatic oxidative stress following acute stress in this fish was associated with differences in cortisol levels and liver metabolic responses. Dietary genistein was associated with altered pituitary regulation of pomc paralogs, characterized by reduced pomcb and elevated pomca expression after stress. These expression patterns persisted 4.5 months after dietary exposure, with pomca becoming the only gene showing a positive association with plasma cortisol levels. In addition, genistein supplementation was associated with higher basal expression of the ACTH receptor (mc2r) in the head kidney. Stress challenges performed up to one year after the nutritional intervention revealed convergence of cortisol responses among dietary groups. Overall, these results indicate that dietary components can produce short-term changes in the regulation of the HPI axis. Further studies are required to clarify the mechanisms underlying the dietary effects observed in this study. - Source: PubMed
Publication date: 2026/02/19
Navarro-Guillén CarmenHuesa-Cerdán RubénHidalgo-Pérez Juan AntonioMartínez-Rodríguez GonzaloRodríguez-Viera LeandroMartos-Sitcha Juan AntonioBlanco-Benítez Juan JoséPerera Erick