ABCG4 antibody
- Known as:
- ABCG4 (anti-)
- Catalog number:
- orb10025
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- ABCG4 antibody
Related genes to: ABCG4 antibody
- Gene:
- ABCG4 NIH gene
- Name:
- ATP binding cassette subfamily G member 4
- Previous symbol:
- -
- Synonyms:
- WHITE2
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-16
- Date modifiied:
- 2016-10-05
Related products to: ABCG4 antibody
Related articles to: ABCG4 antibody
- Pulmonary alveolar proteinosis (PAP) is a rare lung disease with primary (usually autoimmune) and secondary forms. Unlike the autoimmune type, which can be treated with cytokine therapy or whole-lung lavage, the secondary form associated with occupational particulate exposure, such as indium compounds, has no established therapy and remains challenging to treat. - Source: PubMed
Publication date: 2026/06/07
Jeon SoyeonKim GyuriCho Wan-Seob - Alloantigen H is one of thirteen systems in the chicken. Little is known about this system which has two serological alleles. The objectives of this study were (1) to identify the genetic region encoding the chicken alloantigen H, and (2) to develop DNA detection-based methods to aid H system allele identification. - Source: PubMed
Publication date: 2026/03/31
Fulton Janet EMcCarron Amy MWolc AnnaSparling Brandi AAli LowdanJaeger CourtneyTaylor Robert L - Docetaxel (DTX) is a standard chemotherapy agent for castration-resistant prostate cancer (CRPC); however, DTX resistance remains a major clinical challenge, and the underlying molecular mechanisms are not fully understood. In our study, it was found that OTUB2 was highly expressed in DTX-resistant CRPC and could be served as a key driver of DTX resistance. Mechanistically, OTUB2 stabilizes the m5C reader ALYREF by removing its K48-linked polyubiquitin chains, leading to increased ALYREF protein levels. And then, ALYREF enhances the mRNA stability and expression of ABCG4, thereby promoting ATP-dependent efflux of DTX. Moreover, the expression of OTUB2 mRNA and protein could be regulated by FOXD3-AS1 derived from cancer-associated fibroblasts (CAFs). More importantly, treatment with OTUB2 inhibitor (OTUB2-IN-1) resensitized resistant CRPC to DTX. Together, our findings establish OTUB2 as a novel driver of DTX resistance in CRPC and highlight the role of CAFs-derived FOXD3-AS1 and OTUB2/ALYREF/ABCG4 axis in modulating DTX resistance of CRPC. - Source: PubMed
Publication date: 2026/03/17
Ke Zhi-BinChen Jia-YinLin BinChen Chao-RanXue Yu-TingSun Jiang-BoYan Zi-HengZhao Yu-XuanLiu Meng-XinWang ZhenXue Xue-YiZheng Qing-ShuiWei YongXu Ning - Essential tremor (ET) is the most common adult-onset movement disorder, yet its genetic basis remains incompletely understood. Although familial aggregation is well recognized, ET shows marked genetic heterogeneity, with many rare and family-specific variants reported. - Source: PubMed
Publication date: 2026/02/25
Aghayev AgharzaErdoğdu MeldaAydemir DuyguBagirova GulendamAslanger Ayca DilrubaCankay Tugba UyarAkcakaya Nihan HandeUyguner Zehra Oya - The mosquito Aedes albopictus is an important vector of dengue, chikungunya, and Zika; and is a globally distributed invasive mosquito with increasing resistance to insecticides, thereby posing a serious risk to global public health. Symbiotic gut bacteria have been shown to be related to insecticide resistance, but knowledge is still limited for A. albopictus. Here, we explored the role of Serratia marcescens, a gut symbiotic bacterium, in the resistance of A. albopictus to the insecticide deltamethrin. Using 16S-rRNA sequencing we found that S. marcescens was significantly enriched in A. albopictus after deltamethrin exposure, and that resistance increased after S. marcescens enrichment. The enzymatic activities of mixed-function oxidase (MFO) and glutathione S-transferase (GST), two important detoxification enzymes, were higher in the bacteria-enriched mosquitoes. The expressions of ABCG4 and GSTD1, two genes related to detoxification metabolism, were up-regulated following S. marcescens infection and after deltamethrin exposure, as assayed using RNA-seq. The up-regulation of these two genes was most significant in midgut and Malpighian tubules. Our results suggest that S. marcescens infection could enhance deltamethrin resistance in A. albopictus by increasing detoxification metabolism; of interest for designing more efficient mosquito control measures. - Source: PubMed
Publication date: 2025/05/08
Deng Si-JiaTu LeiLi LinHu Ju-PingLi Ju-LinTang Jian-XiaZhang Mei-ChunZhu Guo-DingCao Jun