Murine MDC / CCL22, Source: E. Coli, Protein
- Known as:
- Murine MDC / CCL22, Source: E. Coli, Protein
- Catalog number:
- w1680.960.020
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biochrom GmbH
- Gene target:
- Murine MDC / CCL22 Source: . Coli Protein
Related genes to: Murine MDC / CCL22, Source: E. Coli, Protein
- Gene:
- CCL22 NIH gene
- Name:
- C-C motif chemokine ligand 22
- Previous symbol:
- SCYA22
- Synonyms:
- MDC, STCP-1, ABCD-1, DC/B-CK, A-152E5.1, MGC34554
- Chromosome:
- 16q21
- Locus Type:
- gene with protein product
- Date approved:
- 1997-08-22
- Date modifiied:
- 2016-10-05
Related products to: Murine MDC / CCL22, Source: E. Coli, Protein
Related articles to: Murine MDC / CCL22, Source: E. Coli, Protein
- Excessive inflammation is a critical contributor to impaired oral mucosal wound healing, yet effective therapeutic strategies are still lacking. Although dehydrocorydaline (DHC) has been reported to exhibit anti-inflammatory and analgesic properties, its role in wound healing and the underlying mechanisms have not been fully elucidated. This study aimed to investigate whether DHC accelerates palatal wound healing and to elucidate the role of the p38 mitogen-activated protein kinase (MAPK)/CCL2 signaling axis in DHC-mediated regulation of macrophage chemotaxis. , macrophages were stimulated with 1 μg/mL lipopolysaccharide (LPS) and treated with DHC at 0.1, 1, and 10 μM. The chemotactic response and inflammatory function of macrophages were assessed using real-time PCR, ELISA, Western blotting, and Transwell assays. Molecular docking simulations and Western blotting analyses were performed to examine the regulatory effect of DHC on MAPK signaling pathway. , a full-thickness palatal mucoperiosteal wound extending from the left maxillary first to third molars was established in mice by scalpel scraping. The effects of topical 10 μM DHC gel on wound healing were evaluated using stereomicroscopy, histological staining, and real-time PCR at 0, 3, and 5 days post-modeling. , DHC effectively downregulated the expression of chemokines, including C-C motif chemokine ligand 2 (), , , C-X-C motif chemokine ligand 10 (), and , with the most significant inhibitory effect on (70.8% inhibition). In Transwell assays, DHC reduced macrophage migration by 68.2%. Mechanistically, DHC prominently inhibited the activation of the MAPK signaling pathway. , DHC treatment accelerated wound healing and markedly reduced macrophage infiltration in mouse palatal wound tissues. These findings demonstrated that DHC accelerated palatal wound healing 1.6-fold in mice. DHC suppressed macrophage chemotaxis by 68.2% through modulation of the MAPK signaling pathway. - Source: PubMed
Publication date: 2026/08/27
Chen YingyiLiu ZhaonaWang YijiaXia GuiyangLiu YitongXia HuanWang MinfengLin ShengLiu Yi - Maternal inflammation is linked to adverse maternal and fetal outcomes, but how maternal inflammation affects fetal inflammation during mid-gestation is not known. - Source: PubMed
Goin Dana ELi LinGaw Stephanie LMorello-Frosch RachelWoodruff Tracey JEick Stephanie MRobinson Joshua F - Air pollution has been associated with the development and exacerbation of atopic dermatitis (AD), but the molecular signatures connecting pollutant-related targets with AD-associated immune dysregulation remain incompletely characterized. - Source: PubMed
Publication date: 2026/09/03
Gao ChangChen LipingHuang TianfengWang Zi - HIV-exposed uninfected (HEU) infants experience multiple health complications compared to HIV-unexposed (HUU) infants, including immune dysregulation in the first year of life. exposure to maternal inflammation associated with HIV infection is a proposed mechanism of HEU immune dysregulation. This study compared markers of inflammation and immune activation over the first year of life between HEU and HUU infants. - Source: PubMed
Publication date: 2026/09/03
Roseto IsabelleSilveira LoriCurtis KailiCanniff JenniferWeinberg AdrianaSmith Christiana - Understanding alterations in immune homeostasis can help early diagnosis and prevention in rheumatoid arthritis (RA). As joint pain often precedes RA onset, we analysed pain-associated immune mediators in individuals at risk of RA (RISK-RA) and in early untreated RA. Serum CCL22 levels were elevated in both groups, prompting us to further study its sources and effects in RA. - Source: PubMed
Publication date: 2026/09/16
Filipović MašaAfonso MarceloArgyriou AlexandraCîrciumaru AlexandraJoshua VijayRingh MikaelGrönwall CarolineCarlberg KonstantinChen Szu-YingDehara MarinaKrishnamurthy AkilanVivar NancyVan Hulle SenneDecruy TineWähämaa HeidiEkström Tomas JWadsworth Marc HSharma Ravi KumarPadyukov LeonidElewaut DirkVenken KoenAskling JohanWinkler AaronSmith Julia EKlareskog LarsCatrina Anca IHensvold AaseMalmström VivianneChemin KarineRéthi Bence