Aminoallyl dUTP [5_(3_Aminoallyl)_2_deoxyuridine 5_triphosphate, trisodium salt] *UltraPure Grade* *4 mM in TE buffer*
- Known as:
- Aminoallyl dUTP [5_(3_Aminoallyl)_2_deoxyuridine 5_triphosphate, trisodium salt] *UltraPure Grade* *4 mM TE buffer*
- Catalog number:
- 17004
- Product Quantity:
- 500
- Category:
- -
- Supplier:
- FanBo Biochemicals
- Gene target:
- Aminoallyl dUTP [5_(3_Aminoallyl)_2_deoxyuridine 5_triphosphate trisodium salt] *UltraPure Grade* *4 buffer*
Related genes to: Aminoallyl dUTP [5_(3_Aminoallyl)_2_deoxyuridine 5_triphosphate, trisodium salt] *UltraPure Grade* *4 mM in TE buffer*
- Gene:
- DUT NIH gene
- Name:
- deoxyuridine triphosphatase
- Previous symbol:
- -
- Synonyms:
- dUTPase
- Chromosome:
- 15q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-09-28
- Date modifiied:
- 2015-08-25
Related products to: Aminoallyl dUTP [5_(3_Aminoallyl)_2_deoxyuridine 5_triphosphate, trisodium salt] *UltraPure Grade* *4 mM in TE buffer*
((Cys31,Nva34)_Neuropeptide Y (27_36))2 Salt _ Binding (Disulfide_bond) Synonym SumFormula C116H186N36O28S2((Cys31,Nva34)_Neuropeptide Y (27_36))2 Salt _ Binding (Disulfide_bond) Synonym SumFormula C116H186N36O28S2(+)-(2S,5R)-1-Allyl-2,5-dimethylpiperazine, (+)-Camphoric Acid Salt C19H34N2O4 CAS: 186094-00-8(+)-(2S,5R)-1-Allyl-2,5-dimethylpiperazine, (+)-Camphoric Acid Salt CAS: 186094-00-8 Formula: C19H34N2O4(+)-5-Fluoro-2'-deoxyuridine (+)-5-Fluoro-2'-deoxyuridine For research use only.(+)-Biotin 4-Amidobenzoic Acid, Sodium Salt C17H20N3NaO4S CAS: 102418-74-6(+)-Biotin 4-Amidobenzoic Acid, Sodium Salt CAS: 102418-74-6 Formula: C17H20N3NaO4S(+)-Tianeptine Monosodium Salt C21H24ClN2NaO4S CAS: 169293-32-7(+)-Tianeptine Monosodium Salt CAS: 169293-32-7 Formula: C21H24ClN2NaO4S(+)_3_Bromocamphor_8_sulfonic acid ammonium Salt(+)_Dipara tolouyl_d_tartaric acid salt of 4_(+)_Usnic acid sodium salt Usnic acid sodium salt(+/-)-Iso Myosmine , Technical Grade CAS: 53844-46-5 Formula: C9H10N2 (+_-)-Iso Myosmine , Technical Grade C9H10N2 CAS: 53844-46-5 (+__)_3_Methyl_2_oxovaleric acid Sodium salt Related articles to: Aminoallyl dUTP [5_(3_Aminoallyl)_2_deoxyuridine 5_triphosphate, trisodium salt] *UltraPure Grade* *4 mM in TE buffer*
- Mitochondrial dysfunction has been implicated in the pathophysiology of sepsis. However, human genetic evidence linking mitochondria-related genes to sepsis susceptibility remains limited. This study aimed to identify mitochondria-related genes associated with sepsis risk using a multi-omics Mendelian randomization framework. - Source: PubMed
Publication date: 2026/08/20
Wang LuGao ZhenWang ChengjinZhao YanDeng ZihuiBai YangYang MengmengZou YuhangKang Hongjun - This study proposes a rice-straw-derived biochar decorated with vanadium oxides and molybdenum carbide (VO-MoC@BC) as a redox-active adsorptive material for a UV/sulfite/iodide (UV/S/I) advanced reduction process that targets PFOA, PFOS and GenX. VO-MoC@BC combines hierarchical porosity with well-dispersed VO and MoC nanodomains, which roughly doubles PFAS adsorption capacity relative to pristine biochar and fits well to the Langmuir model (R ≈ 0.999). Under optimized conditions (pH11.5, C = 5.0 mg L, 0.3 g L catalyst, 2.5 mM sulfite, 0.5 mM iodide, 254 nm UV), the VO-MoC@BC/UV/S/I system achieves pseudo-first-order rate constants of 0.039, 0.033 and 0.045 min for PFOA, PFOS and GenX, corresponding to half-lives of 21-15 min and nearly complete removal within 120 min. In a two-step configuration where PFAS are pre-adsorbed in the dark and then irradiated (adsorb-then-UV/S/I), the PFOS defluorination fraction reaches ∼0.42 after 120 min, compared with only ∼0.09 for homogeneous UV/S/I without catalyst, confirming the crucial role of interfacial adsorb-and-reduce chemistry. Radical-quenching and probe experiments show that hydrated electrons dominate PFAS destruction (≈64% contribution), followed by SO• and I•/I•, with minor roles from •OH and O, and the measured electron equivalents correlate linearly with released F equivalents (slope ≈0.8), indicating efficient utilization of reducing equivalents. The process maintains k_obs values in the 10-10 min range across diverse real-water matrices (tap, surface, groundwater, wastewater effluent and seawater) and shows good operational reusability over ten consecutive cycles with low V and Mo leaching. - Source: PubMed
Publication date: 2026/09/01
Le Phuoc-CuongVu Dinh NgoMinh Thi ThaoNhat TanBui Dinh Nhi - 2D metal-free carbon nitride (CN) with extensive π-π conjugated structures suffers from electron localization due to p orbital overlap, which severely limits its photocatalytic CO reduction performance. Herein, we propose an electron delocalization strategy via functional group-modified heteroatom doping. Through DFT screening and three-step copolymerization of phytic acid and urea, we precisely synthesized a 4-coordinated OH-bridged P-doped carbon nitride (CN-POH) featuring a unique 2N-P═OOH microstructure within heptazine units. CN-POH achieves a CO production rate of 1.82 mmol g h, 15 times higher than pristine CN. Experimental and theoretical results reveal that P doping disrupts the π-π conjugation, triggering electron delocalization and transferring electrons to adjacent active N sites. The OH-modified P atom forms 2N-P═OOH coordination, inducing spatial charge polarization between VBM and CBM, which significantly enhances charge separation and electron delocalization. This unique structure also converts CO adsorption from physical to chemical mode under the effect of water solvents and facilitates CO-to-CO conversion via hydrogen bonding with the water solvent. Collectively, CN-POH emerges as a highly efficient photocatalyst for CO reduction. This work provides a promising strategy for electron delocalization in CN materials and introduces a new reaction mechanism incorporating solvent molecule interactions. - Source: PubMed
Publication date: 2026/09/01
Shi HainanKong RuilingWang HaozhiLin JianbinZhou YidaXu ShutaoGuo Xinwen - Butyrylcholinesterase (BChE) plays a key role in preserving appropriate cholinergic neurotransmission that is essentially altered in the brains of advanced Alzheimer's disease (AD), hence a therapeutic target. This study employed a machine learning (ML) bioactivity predictive model to explore the chemical space of potential BChE inhibitors. A cheminformatics pipeline was explored to create a ML model for BChE inhibition using structural insights complemented with a comprehensive variance importance plot (VIP) and correlation matrix analysis. Specifically, a compiled library of 2179 secondary metabolites (SMs) from 50 Nigerian medicinal plants with reported cholinergic activity was investigated using the ML model. After which, molecular modelling was used to further screen the active SMs (827). The final predicted models demonstrated significant robustness, with a correlation coefficient of 0.8981. Molecular docking investigation of the 827 SMs identified the top five candidates based on their scores: three triterpenoids (adipedatol, lupenone and β-amyrin), one steroid (9 (11)-dehydroergosterol benzoate) and one flavonoid (tiliroside). These leads exhibited favourable ADMET properties and promising safety profiles. Among these five, lupenone (-48.78 kcal/mol), β-amyrin (-49.19 kcal/mol) and adipedatol (-48.87 kcal/mol), from and Alchornea laxiflora, respectively, were the most promising leads with significant binding free energy compared to decamethonium (-17.64 kcal/mol) and more favourable van der Waals, electrostatics and nonpolar solvation energetics. Furthermore, the binding of these leads resulted in optimised interaction profiles that preserved the structural integrity of the BChE and aligned well with desirable drug-like characteristics. These findings position the leads as promising candidates for therapeutic applications targeting BChE for AD management, subject to further in vitro and in vivo validation investigations. - Source: PubMed
Publication date: 2026/08/31
Gyebi Gideon AmpomaOnesi Onomeyimi OSabiu Saheed - Volatile siloxanes are persistent molecular contaminants in industrial gas streams and represent a significant concern in aerospace environments, where trace-level outgassing can lead to deposition on sensitive surfaces and performance degradation. While Metal-Organic Frameworks (MOFs) have emerged as promising adsorbents for siloxane capture, the adsorption behavior of structurally distinct linear and cyclic siloxanes under dilute conditions remains poorly understood, particularly in relation to pore architecture-dependent mechanisms. Here, we combine very low-pressure gravimetric adsorption measurements at 303 K with Grand Canonical Monte Carlo (GCMC) simulations to investigate the adsorption of hexamethyldisiloxane (L2) and octamethylcyclotetrasiloxane (D4) in three MOFs with contrasting pore structures: PCN-777(Zr), DUT-4(Al), and MIL-101(Cr). The results indicate that siloxane adsorption is governed by distinct mechanistic regimes depending on framework topology rather than a single adsorption pathway. DUT-4(Al) exhibits a confinement-driven regime characterized by ultralow-pressure uptake and strong host/guest interactions, associated with limited reversibility and enhanced retention, particularly for D4. PCN-777(Zr) follows a cooperative pore-filling regime at higher pressures, which limits its efficiency under trace conditions. MIL-101(Cr) displays intermediate adsorption onset with improved reversibility, resulting in a balanced uptake-regeneration behavior. Across all frameworks, D4 consistently adsorbs more strongly than L2, reflecting enhanced stabilization of cyclic siloxanes in confined environments, while remaining sensitive to pore architecture. Overall, this study provides a mechanistic description of siloxane adsorption in MOFs under trace conditions and highlights the role of pore topology in governing adsorption regimes and regenerability. - Source: PubMed
Brântuas Pedro FreireEkka JoyGulcay-Ozcan EzgiRioland GuillaumeMaurin GuillaumeDevautour-Vinot Sabine