ACADSB Blocking Peptide
- Known as:
- ACADSB Blocking Peptide
- Catalog number:
- 3150BP-50
- Product Quantity:
- 50 ug
- Category:
- -
- Supplier:
- Biovis
- Gene target:
- ACADSB Blocking Peptide
Related genes to: ACADSB Blocking Peptide
- Gene:
- ACADSB NIH gene
- Name:
- acyl-CoA dehydrogenase short/branched chain
- Previous symbol:
- -
- Synonyms:
- SBCAD, ACAD7
- Chromosome:
- 10q26.13
- Locus Type:
- gene with protein product
- Date approved:
- 1994-10-14
- Date modifiied:
- 2019-04-23
Related products to: ACADSB Blocking Peptide
Related articles to: ACADSB Blocking Peptide
- The Changthangi goat, native to the high-altitude Ladakh Plateau in northern India, thrives in oxygen-deficient environments above 4,000 m. This study investigated the genetic basis of high-altitude adaptation in Changthangi goats by integrating comparative genomics and transcriptomics, using the tropical lowland Jamunapari goat as a comparative model. Whole-genome sequence data from 15 individuals per breed were analyzed using complementary selection sweep metrics, including nucleotide diversity, Tajima's D, iHS, CLR, XP-EHH, and FST. These analyses identified candidate genomic regions under strong selective pressure, encompassing genes involved in hypoxia sensing (HIF-1α, HIF-2α/EPAS1, EGLN1), angiogenesis (VEGFA, AGGF1, ZEB1), cardiovascular regulation (PRKCB, ESR1, RYR2), mitochondrial and energy metabolism (ACADSB, ACSS3, ACSL1), cellular stress tolerance (BCL2, ATM), and thermogenesis (UCP1, FGF21). Unlike previous caprine studies that primarily infer hypoxia adaptation from genomic signals alone, our study integrates cardiac transcriptomics to demonstrate that genomic selection in Changthangi goats is accompanied by coordinated transcriptional remodeling across interconnected physiological systems in a physiologically relevant tissue. Comparative cardiac transcriptomic profiling revealed concordant expression divergence in genes associated with oxygen transport, vascular remodeling, mitochondrial function, substrate utilization, redox balance, and genome maintenance. This integrative multi-omics framework provides a mechanistic view of caprine high-altitude adaptation and highlights the value of combining genomic selection analyses with tissue-specific transcriptional profiling to resolve complex adaptive traits. - Source: PubMed
Publication date: 2026/06/11
Parsad RamAhlawat SonikaArora ReenaBagiyal MeenaChhabra PoojaGera RitikaMir M ASingh M K - Type 2 diabetic osteoporosis (T2DOP) is a significant complication of type 2 diabetes, characterized by an increased risk of fractures. While dysregulated bone cell glucose metabolism is implicated, its specific mechanisms are unclear. This research combined bioinformatics with experimental validation to examine glycolysis-related genes in T2DOP. We merged osteoporosis and type 2 diabetes datasets, then applied differential expression analysis, WGCNA, and machine learning (113 algorithms) to identify core biomarkers. Functional enrichment, immune infiltration, and scRNA-seq analyses elucidated their roles. L1000FWD screened potential drugs, validated by molecular docking and in a T2D mouse model. We identified eight key biomarkers (ATN1, PDLIM7, PLD3, ACADSB, PDZK1, RAPGEF4, MYBPC3, BSG) with high diagnostic value (AUC > 0.75). They were enriched in glucose metabolism and osteoclast pathways. Immune analysis revealed altered infiltration, and scRNA-seq indicated their primary influence on osteoblasts, mesenchymal stem cells, and osteoclasts. Calcifediol (25(OH)D₃) was the top drug candidate, showing strong binding affinity. In vivo, 25(OH)D₃ treatment ameliorated bone loss, improved metabolic parameters, and modulated key biomarker expression. Our research identifies eight glycolysis-related genes as candidate diagnostic and therapeutic targets with biological and causal plausibility for T2DOP. Calcifediol demonstrates promise as a preclinical therapeutic candidate for T2DOP, with the potential to enable simultaneous management of diabetic hyperglycemia and osteoporosis, and its clinical value requires further verification in subsequent studies. - Source: PubMed
Publication date: 2026/05/25
Li MiaoLi WeihongMai GenningPan ZhaofengXiao JiacongMa JizhiWang FanchenChen BaihaoMeng ChenhuiZhang JingWang HaibinHe Jiandong - Traditional Chinese medicines (TCMs) demonstrate efficacy in hyperlipidemia prevention and treatment, irrespective of their traditional classifications. However, the molecular mechanisms underlying their hypolipidemic activities remain incompletely defined. This study investigates the lipid-lowering effects and associated mechanisms of three clinically applied TCMs: Citrus reticulata Blanco (Citri Reticulatae Pericarpium, CRP), Nelumbo nucifera Gaertn. (Nelumbinis Folium, NF), Alisma orientale (Sam.) Juzep. (Alismatis Rhizoma, AR). - Source: PubMed
Publication date: 2026/05/14
Wang Xiao-LeLi Jia-YunGuo Yu-HanZhai Guo-HaoFang Ni-YuanPeng Miao-MiaoChen Neng-YuQin BingChen Qian-QianLiu E-Hu - Short/branched-chain acyl-CoA dehydrogenase deficiency (SBCADD) is an autosomal recessive defect of L-isoleucine catabolism caused by pathogenic variants in the ACADSB gene. While early reports described neurological symptoms, expanded newborn screening cohorts have revealed predominantly asymptomatic individuals, raising questions regarding the clinical significance and optimal management. - Source: PubMed
Publication date: 2026/02/19
Bandura AndrejChandoga JánVengríni JergušJuhosová MiriamaVavrová AlžbetaGregová ElenaLysinová MiroslavaMydlová ZuzanaBrennerová KatarínaŠaligová JanaMaceková DankaBöhmer Daniel - Social isolation, characterized by a lack of social connections with family, friends, and others, is associated with adverse health outcomes. However, the genetic contribution to the susceptibility to social isolation remains unclear. This study aimed to identify genetic loci associated with social isolation using the Lubben Social Network Scale (LSNS-6) in a Japanese population. The Tohoku Medical Megabank Community-Based Cohort Study was conducted between 2013 and 2016. The participants were genotyped using the Affymetrix Axiom Japonica Array. The LSNS-6 was used to assess familial and friend ties through six questions and social isolation statuses were defined using the total scale, family subscale, and friend subscale. Genome-wide association studies (GWASs) were conducted using a generalized linear mixed model, adjusting for age, sex, 10 genetic principal components and batch effects. In total, 63,497 participants who completed genotyping and the LSNS-6 were included. The mean age was 59.4 ± 11.9 years, and 41,126 (64.8%) were female. Significant genetic loci were identified in GWASs for the total scale (rs10736933 near ACADSB and HMX3) and friend subscale of LSNS-6 (rs1778366 near LINC02315 and LRFN5). This study provides the first genome-wide evidence of social isolation in the Japanese population, suggesting associations with ACADSB, HMX3, LINC02315, and LRFN5. These findings could enable personalized prevention and intervention for social isolation and related psychiatric disorders. - Source: PubMed
Publication date: 2026/02/17
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