CD147
- Known as:
- CD147
- Catalog number:
- 10-507-C100
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD147
Related genes to: CD147
- Gene:
- BSG NIH gene
- Name:
- basigin (Ok blood group)
- Previous symbol:
- OK
- Synonyms:
- EMMPRIN, CD147, EMPRIN
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-25
- Date modifiied:
- 2019-04-23
Related products to: CD147
Related articles to: CD147
- Investigating fungal gene expression in complex solid-state fermentation (SSF) systems is essential for process optimization but is hindered by challenges in RNA extraction. RNA extraction from fungal samples rich in plant biomass is a special challenge that is not met by the commercial RNA extraction kits and conventional RNA extraction methods we have tested. This study presents an optimized RNA extraction method, suitable for RT-qPCR from agricultural side streams fermented by filamentous fungi. The method was applied to investigate the temporal expression of the class II hydrophobin NC2 in Neurospora intermedia grown on four different sources of brewer's spent grain (BSG): IPA, Pilsner, Stout, and a microbrewery batch. Relative NC2 expression showed a clear temporal increase, peaking on day 6, with the microbrewery BSG batch having the highest peak expression. It demonstrates the applicability of the presented RNA extraction method to monitor expression of a gene of interest during solid-state fermentation of a complex substrate. Furthermore, the RNA extraction protocol was successfully validated on other challenging substrates, including rapeseed press cake and oat hulls, and with other fungi (Aspergillus oryzae and Trichoderma asperellum), consistently yielding high-purity RNA. This work provides a reliable method for RNA extraction from complex SSF products that can be used for gene expression analysis. KEY POINTS: • Reliable RNA extraction protocol developed for complex fungal SSF substrates • Hydrophobin NC2 expression in N. intermedia might be temporally regulated on BSG • Peak NC2 expression (day 6) was observed on BSG from a microbrewery. - Source: PubMed
Publication date: 2026/07/06
Terp MikaelRusbjerg-Weberskov Christian EnricoSondergaard Teis ELübeck Mette - The progression from ductal carcinoma in situ (DCIS) to invasive breast carcinoma (IBC) critically determines patient outcomes, yet its mechanisms remain incompletely understood. Integrating single-cell RNA sequencing, spatial transcriptomics, and genomics across 28 patients with synchronous DCIS and IBC, we delineate the spatial-molecular hierarchy of this transition. Invasion is primarily driven by clonal expansion of pre-existing DCIS subclones, emphasizing transcriptional reprogramming and tumor microenvironment (TME) remodeling over acquisition of additional driver alterations. IBC cells exhibit pronounced epithelial-mesenchymal transition and metabolic reprogramming. We uncover dynamic TME remodeling at the invasive front, identifying key ligand-receptor interactions (e.g., PPIA-BSG, MDK-LRP1, CXCL12-CXCR4) facilitating basement membrane disruption, angiogenesis and immunosuppression. Deconvolution of basement membrane breach reveals four molecularly defined stages (NMFT1-NMFT4) with progressively worsening patient survival. This study establishes a unified spatial-molecular atlas of DCIS-IBC progression, highlighting clonal expansion, transcriptional plasticity and TME remodeling as key drivers of invasion. - Source: PubMed
Publication date: 2026/07/02
Wang DiDai QichenGuo JingwenLi DanGuo ChangyuanMa PeiqingWen FengTong XiangyuGong ChanghaoCheng HanLi MengWang RanjiaxiLiu JianlinFeng YingyingFan FengpuShi XiaoqianZhang QianShu XingmeiSun YuShen XunanDeng ZiqingLiu JiaqiMa FeiWang YipengFeng Lin - This study aimed to assess the effect of bridging stent graft (BSG) selection on the outcomes of endovascular aneurysm repair using an iliac branch device (IBD) and to compare the performance of the Advanta V12 and BeGraft Plus stent grafts for this purpose. - Source: PubMed
Publication date: 2026/06/30
Marques de Marino PabloKirchner LucaKatsargyris AthanasiosMinarech ViliamScaratti RobertoVerhoeven Eric L G - Iron deficiency anaemia (IDA) accounts for a significant proportion of all gastroenterology referrals. Current British Society of Gastroenterology (BSG) guidance recommends bidirectional endoscopy as first-line investigation and reserves small-bowel or renal-tract investigation for patients with recurrent IDA or inadequate response to iron replacement therapy (IRT) after negative endoscopy. Advanced imaging modalities represent high financial costs to the NHS, but their diagnostic yield in this specific cohort is debated. - Source: PubMed
Publication date: 2026/05/27
Iqbal Hassan - This work presents the production of fungal conidia from the thermotolerant and entomopathogenic fungi Metarhizium robertsii, by means of solid-state fermentation (SSF) in packed-bed bioreactors (PBR) up to a pilot scale of 100 L. The M. robertsii strain used (EAMa 01/158-su) presents both thermotolerant and entomopathogenic properties. Its thermotolerance is an unusual trait as entomopathogenic strain, and can help to surpass heat accumulation, the main limitation when increasing scale in SSF. Using a mixture of beer spent grains (BSG) and wood chips as substrates, work is performed at 3 different scales: laboratory (0.5 L), bench (22 L) and pilot (100 L). Air-filled porosity (AFP), specific airflow (sAF) and superficial velocity (V) were chosen as parameters to compare across scales. At 0.5 L, production time was optimised at 5 days. At 22 L, successful batch operation yielded homogeneous production throughout the packed bed. At pilot scale of 100 L, conidia production (conidia gBSG) and yield achieved were not significantly different from values achieved at 0.5 L, confirming the robustness of the process across reactor volumes. The results highlight the relevance of AFP, sAF and V as critical parameters for SSF reactor design and process evaluation and provide a basis for future industrial implementation of fungal SSF in PBR. This work validates thermotolerant entomopathogenic fungi as a viable strategy for industrial-scale SSF in packed-bed bioreactors, demonstrating the potential of thermotolerant entomopathogenic strains in fungal PBR conidia production by reaching pilot scale of 100 L. - Source: PubMed
Publication date: 2026/06/26
Sala ArnauArtola AdrianaGea TeresaBarrena Raquel