CD300a
- Known as:
- CD300a
- Catalog number:
- 1P-501-T025
- Product Quantity:
- 25 tests
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD300a
Related genes to: CD300a
- Gene:
- CD300A NIH gene
- Name:
- CD300a molecule
- Previous symbol:
- -
- Synonyms:
- Irp60, CMRF35H, CMRF-35-H9, IRC1, IRC2, IGSF12
- Chromosome:
- 17q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-02-08
- Date modifiied:
- 2016-10-05
Related products to: CD300a
anti-CD300Aanti-CD300Aanti-CD300A type: Primary antibodies host: MouseAntibodies: Mouse Monoclonal to CD300a, Species Reactivity: Human, Clone: MEM-260, Isotype: IgG1Antibodies: Mouse Monoclonal to CD300a, Species Reactivity: Human, Clone: MEM-260, Isotype: IgG1Antibodies: Mouse Monoclonal to CD300a, Species Reactivity: Human, Clone: MEM-260, Isotype: IgG1Antibodies: Mouse Monoclonal to CD300a, Species Reactivity: Human, Clone: MEM-260, Isotype: IgG1Bovine CMRF35-like molecule 8(CD300A) ELISA kitCanine CMRF35-like molecule 8(CD300A) ELISA kitCanine CMRF35-like molecule 8(CD300A) ELISA kitCD2AP Gene CD2-associated proteinCD300 antigen-like family member A,Cd300a,CLM-8,CMRF35-like molecule 8,Rat,Rattus norvegicusCD300 antigen-like family member A,CD300A,CLM-8,CMRF35H,CMRF35-H,CMRF-35-H9,CMRF35-H9,CMRF35-like molecule 8,Homo sapiens,HSPC083,Human,IgSF12,IGSF12,Immunoglobulin superfamily member 12,Inhibitory reCD300 antigen-like family member A,Cd300a,Clm8,CLM-8,CMRF35-like molecule 8,Leukocyte mono-Ig-like receptor 1,Lmir1,MAIR-1,MAIR-I,Mast cell-derived paired immunoglobulin-like receptor 1,Mcpir1,Mouse,MCD300A CMRF35H IgG1 antibody Ab host: Mouse Related articles to: CD300a
- The delayed healing of diabetic wounds involves both impaired efferocytosis and dysfunctional phosphatidylserine (PS) receptor signaling, leading to macrophage defects in migration, persistent M1 polarization, and diminished cellular resilience. To address this multifaceted pathology, a bioactive wound dressing was developed by incorporating PEGylated RGD-grafted phosphatidylserine liposomes (PEG/RGD-PSLs) into a photocrosslinkable hyaluronic acid methacryloyl (HAMA) hydrogel matrix. This platform provides sustained, delivery of a biomimetic "eat-me" signal while actively reprogramming macrophage behavior. Under diabetic-mimicking stress conditions, PEG/RGD-PSLs significantly enhanced macrophage migration, promoted M1-to-M2 phenotypic transition, and conferred robust cytoprotection by preserving mitochondrial integrity, attenuating oxidative stress, and suppressing pathological extracellular vesicle release. Mechanistically, PS binding upregulated the inhibitory receptor CD300a, which suppressed the MyD88/NF-κB pathway and downregulated pro-inflammatory genes. Critically, siRNA-mediated CD300a knockdown abolished these anti-inflammatory and NF-κB-suppressive effects, establishing CD300a as necessary for therapeutic action. In a diabetic rat model, a single application of the bioactive hydrogel significantly accelerated wound closure, stimulated angiogenesis, improved organized collagen deposition, and actively shifted the wound immune microenvironment toward a pro-reparative M2-dominant state. Collectively, this study identifies the PS/CD300a/NF-κB axis as a key regulatory node for rescuing macrophage dysfunction and establishes a functionally active hydrogel-based therapy for chronic diabetic wounds. - Source: PubMed
Publication date: 2026/08/30
Wu LeleHao XuetongZou YangChen XinglinKong JunyanGu ChunningMa WenjieYang ZhongjunLiu HuifenLiu MengmengTong Xin - Atopic dermatitis (AD) is a common pediatric skin disorder with early onset and complex pathophysiology. Tape-strip sampling has enabled minimally invasive molecular profiling of skin lesions in children, yet approaches that verify and standardize stratum corneum (SC) sampling depth have remained limited. - Source: PubMed
Publication date: 2026/07/12
Andersen DanielYélamos OriolCombalia MarcIglesias PabloPotrony MiriamDanneskiold-Samsøe Niels BKristiansen KarstenThysen Anna HGuy Richard HMalvehy JosepRøpke MadsPont MercèPuig SusanaBrix Susanne - Dengue virus serotype-3 (DENV-3) infection remains a clinical problem for which no specific antiviral agent has yet been identified. The rhizome of (red galangal) is rich in natural glycosides with antioxidant and anti-inflammatory properties. However, studies related to antidengue from using and methods have not been widely conducted. - Source: PubMed
Publication date: 2026/05/31
Herdiansyah Mochammad AqilahDarmanto WinWinarni DwiRohmatika Aulia UmiPutri Rr Aulia Rahmawati KusumaSusilo Raden Joko KuncoroningratSucipto Teguh HariWiradana Putu AnggaKhanifah FarachErnawati Ernawati - Breast cancer (BC) is a common cancer type in women and a major cause of death. CD300a is an inhibitory receptor expressed on immune cells, particularly mast cells (MCs). CD300a ligands expression was found on several cancer cells. We hypothesized that CD300a has a role in suppression of anti-tumor immunity in BC. - Source: PubMed
Publication date: 2026/03/23
Ben-Zimra MichaNiazov ShiranRahimli Alekberli FidanLevi-Schaffer Francesca - Zika virus (ZIKV) causes severe neurological disease, including microcephaly and Guillain-Barré syndrome, through complex interactions with host cell proteins. This review synthesizes the 2015-2025 published literature on ZIKV-host protein interactions and their therapeutic targeting. ZIKV enters cells via multiple receptor pathways: adhesion receptors (DC-SIGN, Hsp70), high-affinity entry receptors (ITGB4, GRP78, NCAM1), internalization receptors (integrin αvβ5, sialic acid), and endosomal receptors (AXL, TIM-1, CD300a). Viral structural proteins direct virion assembly, while nonstructural proteins NS1-NS5 suppress immune responses, remodel cellular membranes, and dysregulate gene expression. NS5 uniquely suppresses neurodevelopmental genes and disrupts ciliary function through nuclear localization, directly driving microcephaly pathogenesis. Therapeutic strategies include receptor antagonists, protease inhibitors, and polymerase inhibitors. However, receptor redundancy, viral protein multifunctionality, and pregnancy safety constraints limit clinical translation. This review identifies ZIKV-host protein interactions as therapeutic targets and highlights barriers to drug development. - Source: PubMed
Publication date: 2026/02/04
Han XiaodongDu JiansenLi WenhuiYang ShuqianSun HuamuziWang GuihuaCong Haolong