CD59
- Known as:
- CD59
- Catalog number:
- 10-388-C100
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD59
Related genes to: CD59
- Gene:
- CD59 NIH gene
- Name:
- CD59 molecule (CD59 blood group)
- Previous symbol:
- MIC11, MIN1, MSK21, MIN2, MIN3
- Synonyms:
- 16.3A5, EJ16, EJ30, EL32, G344, p18-20
- Chromosome:
- 11p13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2019-04-23
Related products to: CD59
Related articles to: CD59
- Neuroinflammation can be triggered by traumatic brain injury (TBI) and exposure to toxicants such as chlorpyrifos (CPF), leading to chronic disabilities and substantial health care costs. CD59 and glial maturation factor-beta proteins are implicated in various brain regulatory mechanisms. Investigating their roles can provide valuable insights into their role in pathologies such as TBI. - Source: PubMed
Publication date: 2026/02/28
Castro-Vargas Rafael EnriqueHerrera-Sánchez María PaulaRondón-Barragán Iang - Obstructive sleep apnea (OSA) is highly prevalent and triples cardiovascular risk. Intermittent hypoxia during apneas impairs endothelial cell (EC) protection against complement, which initiates endothelial inflammation and increases cardiovascular risk. This process appears to be linked to altered cellular cholesterol metabolism. However, whether and how intermittent hypoxia alters endothelial cholesterol homeostasis and whether those changes affect endothelial inflammation in patients with OSA are unclear. - Source: PubMed
Publication date: 2026/06/30
Gao SuShah Vikash KEmin MemetChang AudreyShah RiddhiArea Gomez EstelaWei YingJelic Sanja - Renal-resident macrophages (RMs) are essential regulators of kidney homeostasis and repair, yet the mechanisms governing RM niche regeneration after acute depletion remain poorly defined. To overcome these limitations, we have developed an inducible human CD59- intermedilysin (hCD59-ILY) ablation system, enabling rapid, specific, and reversible depletion of targeted macrophage populations, and subsequent replenishment of RMs, followed by longitudinal scRNA-seq analysis of kidneys at baseline and days 1, 3, and 7 post-ablation. RM ablation triggered a rapid and sustained upregulation of , predominantly in proximal tubular epithelial cells (PTC1/PTC2), establishing a persistent chemotactic niche signal that coincided with macrophage repopulation. Regenerating RMs transitioned from inflammatory/stress-associated states toward metabolically active and proliferative phenotypes enriched in glycolysis, oxidative phosphorylation, MYC, and cell-cycle programs, with attenuation of canonical inflammatory pathways. Cell-cell communication analysis revealed an early burst of intercellular signaling at day 1, followed by progressive normalization, with fibronectin ), osteopontin (), chemokine (), and amyloid precursor protein () axes emerging as key mediators of niche restoration. Transcriptional network analysis identified a conserved regulatory module (, , , , , ) coordinating macrophage differentiation and regenerative programming, linking metabolic adaptation to lineage reconstitution. Sub-clustering revealed five dynamically shifting RM subsets with distinct inflammatory, remodeling, proliferative, and surveillance states, reflecting a hierarchical regeneration process. Functional validation using clodronate-mediated depletion in Secreted Phosphoprotein 1 (Opn)-deficient mice demonstrated impaired macrophage repopulation, establishing osteopontin as a critical regulator of RM regeneration. Together, these data define a coordinated epithelial-immune circuit in which Cx3cl1-driven chemotaxis, -dependent signaling, and a core transcriptional network orchestrate macrophage niche reconstitution and kidney repair following acute immune cell ablation. - Source: PubMed
Publication date: 2026/06/18
Islamuddin MohammadJi LixuanChen YilinSong KejingEllsworth Calder RRappaport JackWang ChenxiaoLiu ShumeiKolls JayXu XiaojiangQin Xuebin - Diabetic retinopathy and diabetic nephropathy are major microvascular complications of type 2 diabetes mellitus and may progress silently before clinical detection. Plasma glycated CD59 has been proposed as a marker linked to complement-mediated endothelial injury. This study assessed plasma glycated CD59 levels in type 2 diabetic patients with retinopathy, nephropathy, and combined microvascular complications. - Source: PubMed
Publication date: 2026/06/20
Chinta BhagatsinghKandimalla RameshAmbati Ranga Rao - COVID-19 has been closely associated with coagulation abnormalities. However, existing biomarkers, including D-dimer and fibrin degradation products (FDP), exhibit limited accuracy in stratifying disease severity and predicting long-term clinical outcomes. - Source: PubMed
Publication date: 2026/06/21
Zhou ZizhenLiu QiweiMa ShuangshuangShi AnkeTao YuzhiHu TianpengYan ShengtaoChen YinongJi XiaofanSun LuZhang HongSong WanluZhang ZhuYang PeiranZhai Zhenguo