CD1a
- Known as:
- CD1a
- Catalog number:
- 11-364-C100
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD1a
Related genes to: CD1a
- Gene:
- CD1A NIH gene
- Name:
- CD1a molecule
- Previous symbol:
- CD1
- Synonyms:
- -
- Chromosome:
- 1q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1988-05-11
- Date modifiied:
- 2017-07-07
Related products to: CD1a
Related articles to: CD1a
- Isolated subcutaneous sarcoidosis is an uncommon form of sarcoidosis, typically presenting as firm, painless nodules beneath clinically normal skin. Its rarity, especially in male patients or in atypical anatomical locations, can mimic malignant or infectious processes and cause significant diagnostic uncertainty. Recognizing this entity is important to prevent misdiagnosis and unnecessary interventions. - Source: PubMed
Publication date: 2026/06/15
Habte Yoseph MHabte Binyam MHabte Makida MAbdu Esimael MOumer Amir MYimer Shimelis A - Langerhans cell histiocytosis (LCH) is a rare hematologic neoplasm predominantly affecting children, with adult-onset cases being exceedingly uncommon. Neurological presentations, including spinal cord compression and cranial neuropathies, represent atypical manifestations that often lead to diagnostic delays. We present a 20-year-old previously healthy female who presented with progressive back pain, bilateral lower extremity weakness, and left-sided hearing loss. Imaging revealed a thoracic epidural mass causing severe spinal stenosis with additional diffuse osteolytic lesions. Initial biopsies showed nonspecific lymphoplasmacytic infiltrates. The patient subsequently developed cranial nerve palsies and dysphagia over several months. Definitive diagnosis required three biopsies, with the final petrous bone specimen demonstrating characteristic LCH histology and positive immunostaining for CD1a, S100, and Langerin. Treatment with zoledronic acid failed; subsequent therapy with cytarabine followed by cladribine plus hydroxyurea achieved partial radiographic and clinical improvement, though complicated by treatment-related sepsis. This case highlights the diagnostic and therapeutic challenges of adult LCH, given its rarity, variable presentation, and limited treatment guidelines. Multiple tissue samples with appropriate immunohistochemical staining may be required for diagnosis. Adult LCH treatment remains empirical, often extrapolated from pediatric data, with systemic therapies carrying significant toxicity risks. Greater awareness and adult-specific clinical trials are urgently needed. - Source: PubMed
Publication date: 2026/07/01
Rong ZhanAbboud AlanPendleton JonathanCherukuri Sashank - Rosai-Dorfman-Destombes disease (RDD) is a rare non-Langerhans histiocytic disorder with occasional extranodal involvement. Orbital disease can mimic neoplastic or inflammatory conditions, leading to diagnostic and therapeutic challenges. Standardized management strategies remain undefined. - Source: PubMed
Publication date: 2026/06/19
Krishna Sanjay ArvindNair Anoop RemesanPerumal Hema AshokEapen MaliniUllattil Pushpaja KuttasseryDutta Debnarayan - Leishmania-HIV coinfection compromises the cutaneous immune response through mechanisms that remain poorly understood. This exploratory study compared the in situ immune microenvironment of skin lesions between coinfected and non-coinfected patients with American tegumentary leishmaniasis (ATL). - Source: PubMed
Publication date: 2026/06/30
Xavier Marília BrasilFontes Lucas Dos SantosMotizuki Airton KenjiAlves Leonardo Ramalho MendonçaRodrigues Gabriela FernandesAlcântara Larissa Dos SantosIshikawa Edna Aoba YassuiBrito Elza Baía deGomes Cláudia Maria de CastroCorbett Carlos Eduardo Pereira - Adult-onset xanthogranuloma (AOXG) is a rare, benign form of non-Langerhans cell histiocytosis. Ocular manifestations commonly involve the orbit, uveal tract, or adnexal tissues; however, concurrent bilateral involvement accompanied by extensive infiltration of the corneoscleral limbus remains exceptionally rare and poses substantial diagnostic and therapeutic challenges. - Source: PubMed
Publication date: 2026/06/12
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