CD63
- Known as:
- CD63
- Catalog number:
- 1P-343-T025
- Product Quantity:
- 25 tests
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD63
Related genes to: CD63
- Gene:
- CD63 NIH gene
- Name:
- CD63 molecule
- Previous symbol:
- MLA1
- Synonyms:
- ME491, TSPAN30
- Chromosome:
- 12q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-07
- Date modifiied:
- 2016-01-15
Related products to: CD63
Related articles to: CD63
- Predictive biomarkers for pembrolizumab resistance and durable clinical benefit in advanced non-small cell lung cancer (NSCLC) remain insufficient. - Source: PubMed
Publication date: 2026/09/29
Hirano YutaYagishita ShigehiroShinno YukiGoto YasushiAraya JunYamamoto YusukeFujita Yu - Glioblastoma (GBM) has a poor prognosis, and temozolomide (TMZ) therapy is limited by a short half-life and insufficient intratumoral availability. We developed a bevacizumab (BVZ)-functionalized, exosome-associated chitosan nanocomposite loaded with TMZ (BVZ-Exo@CS-TMZ) as a multifunctional biohybrid platform for experimental glioma therapy. - Source: PubMed
Publication date: 2026/09/28
Pourmasoumi ParvinZamani FarshidBayat MohammadAmini Abdollah - High-efficiency and specific isolation of exosomes from diverse biological fluids remains a major challenge for clinical diagnostics. Herein, we developed an aptamer-functionalized dual-network hydrogel platform for the specific enrichment and non-destructive release of exosomes. This study proposes an aptamer-functionalized dual-network hydrogel technology aimed at achieving the specific separation and non-destructive release of exosomes from complex biological samples. Using a sacrificial nickel foam template, polyacrylamide and polyacrylic acid were sequentially polymerized to construct a stable, interconnected macroporous hydrogel framework, which minimized flow resistance for rapid sample permeation. To build the affinity interface, circular DNA templates were chemically crosslinked into the accessible carboxyl groups of the polyacrylic acid segments, followed by in situ rolling circle amplification (RCA) to generate long DNA concatamers rich in repetitive CD63 aptamer sequences for efficient target capture. Meanwhile, polyacrylic acid is expected to reduce the non-specific adsorption of the composite hydrogel toward contaminating proteins, thereby improving the purity of the isolated exosomes. Finally, introducing complementary DNA displacement strands enables efficient, mild vesicle release via competitive hybridization, fully preserving structural integrity and cellular uptake ability. This bio-functionalized hydrogel system provides a gentle, efficient, and reliable methodology for high-purity exosome isolation, offering a promising tool for advanced biomedical applications. - Source: PubMed
Publication date: 2026/10/01
Tan WeiRen YanJia XuemeiGuo YanfeiYao ChiYang Dayong - Gastric infection by () is associated with extra-gastric pathologies. can promote these pathologies by generating extracellular vesicles (Hp-EVs), which cross biological barriers and access other tissues through the circulation. However, the presence of Hp-EVs in the human circulation has not been demonstrated. We isolated and characterized EVs from serum of non-infected and infected patients, and used immunoblots (IB) to identify markers from host cells EVs (h-EVs) and Hp-EVs. We also assessed the predictive capacity of IB with an anti-Urease subunit B (UreB) antibody to identify true positive cases of infection. Finally, we compared the diagnostic utility of IB-UreB with other detection methods of in blood samples. Thirty symptomatic individuals underwent endoscopy, gastric biopsy and blood tests. Rapid Urease test (RUT), pathological analysis and ® (GP) classified 16 cases (53.3%) as positive. EV markers CD63 and CD81 were detected in all the isolated EVs from the serum of these patients. Moreover, UreB+ EVs were detected in 62.5% of -infected patients, providing the first evidence of circulating Hp-EVs in human serum. Among the blood biomarkers evaluated, IB-UreB+ proved to be the best method for diagnosing -positive cases. Furthermore, combining IB-UreB+ with GP increased its diagnostic value. Our findings provide the first evidence of circulating Hp-EVs in human serum, thereby supporting a mechanism for systemic dissemination of bacterial virulence factors. Additionally, their detection in blood samples may enable minimally invasive diagnosis of infection. - Source: PubMed
Publication date: 2026/09/16
González María FernandaDíaz-Serrano GabrielValenzuela-Valderrama ManuelKogan Marcelo JCorvalán AlejandroQuest Andrew F GLeyton Lisette - Keloids are fibroproliferative disorders characterized by excessive extracellular matrix deposition, and current treatments remain unsatisfactory because of high recurrence rates. Human umbilical cord mesenchymal stem cell-derived exosomes (HUCMSCs-Exo) have emerged as investigational cell-free candidates for the treatment of fibrotic diseases. - Source: PubMed
Publication date: 2026/10/01
Chen ZimiaoLu LinaLiu QinChen Xiaosong