CD222
- Known as:
- CD222
- Catalog number:
- 11-315-M001
- Product Quantity:
- 1.0 mg
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD222
Related genes to: CD222
- Gene:
- IGF2R NIH gene
- Name:
- insulin like growth factor 2 receptor
- Previous symbol:
- -
- Synonyms:
- CD222, MPRI, MPR1, CIMPR, M6P-R, CI-M6PR, CI-MPR, MPR300
- Chromosome:
- 6q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1988-07-07
- Date modifiied:
- 2019-04-23
Related products to: CD222
Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1CD222 IGF2R antibody Ab host: RabbitCD222 IGF2R antibody Ab host: RabbitCD222 IGF2R antibody Ab host: RabbitCD222 IGF2R antibody Ab host: RabbitCD222 IGF2R antibody Ab host: Rabbit Related articles to: CD222
- In vitro embryo production (IVP) is a reproductive technology commonly used in the dairy cattle industry for various purposes, such as maximizing the genetic contributions of elite breeding animals. However, IVP has been often associated with increased frequency of Large Offspring Syndrome (LOS) cases, resulting in high calf mortality, welfare concerns, and economic losses. LOS is a developmental disorder in calves characterized by abnormally large birth weight and body size, often accompanied by organ enlargement and other abnormalities. Among the imprinted genes frequently dysregulated in LOS, IGF2R (insulin-like growth factor 2 receptor) is one of the most consistently affected genes. Therefore, the main objectives of this study were to perform a comprehensive characterization of LOS in calves, including an assessment of differences in organ development, physiological parameters, and histopathological examinations between healthy and LOS-affected calves, and evaluate factors influencing its expression in affected Chinese Holstein calves. Data on birth weight, health status, and gestation length were collected from 4,584 IVP-derived Holstein calves and used for the analyses. Subsequently, 17 LOS-affected calves were identified based on birth weight. The data from these calves were statistically compared with that from 6 healthy calves in terms of organ weight, blood biochemical parameters, and pathological changes using general linear models and t-tests. The results showed that the average birth weight of IVP-derived calves was 40.79 ± 6.69 kg. The proportion of healthy calves was highest (86%) among calves with birth weight ranging from 33 to 47 kg, whereas it decreased to 18.4% when birth weight exceeded 61kg. In addition, birth weight was significantly affected by calving season, embryo cryopreservation method, oocyte retrieval season, calf sex, farm, and sire. The comparative analyses showed that LOS-affected calves had significantly greater body weight accompanied by bigger hearts, livers, spleens, lungs, kidneys, and tongues than healthy calves. The ALB of LOS group is significantly higher than the control group, while the glutathione of LOS group was significantly lower than the control. Histopathological examination revealed interstitial pneumonia in the lungs and inflammatory infiltration in the portal area of the liver in LOS-affected calves. To our knowledge, this is the first study establishing a quantitative phenotypic database for LOS diagnosis in Chinese IVP-derived Holstein calves. This study systematically reveals the coordinated characteristics of multi-organ hypertrophy, functional abnormalities, and pathological alterations in LOS calves. These findings provide detailed background information for LOS diagnosis in calves, management practices, and genetic selection for reduced incidence of LOS cases in Holstein calves. - Source: PubMed
Publication date: 2026/09/09
Qu LeiyuBrito Luiz FWang AoHang ZhengyuFang QianhaiMei ChengYang MingluZhang HailiangGao QingshanWang Yachun - The early developmental stages of fish exhibit the highest mortality and greatest environmental sensitivity throughout their life cycle. This period encompasses a series of crucial biological events, including morphogenesis, organ differentiation, and nutritional mode transition from fertilized eggs to newly hatched larvae. Although largemouth bass (Micropterus nigricans) is a commercially important fish species in China, the molecular regulatory mechanisms governing its endogenous nutritional stage remain largely unexplored. To elucidate the molecular basis of this critical period, we performed transcriptomic profiling across six consecutive developmental stages (Multicellular, Blastula, Gastrula, Neurula, Organogenesis, and 5 day post hatching larvae). Our results reveal stage-specific transcriptional programs: the multicellular-to-blastula transition is characterized by stage-specific enrichment of by cell cycle and DNA replication pathways, with MCM complex (mcm2-5) upregulation accelerating proliferation; the blastula-to-gastrula transition features activation of bmp4, fgfr2, and lft1 for germ layer induction; the neurula stage exhibits transcriptional bursts and enrichment of neural tube-related pathways; organogenesis involves simultaneous activation of focal adhesion (col1a1b, col4a5, tnc) and Wnt signaling (wnt1, wnt4, wnt3a) pathway; and 5 dph larvae show visual function maturation, with light transduction genes (gnat1, gnat2, gucy2f, pde6b) identified as hub genes. Mfuzz analysis further reveals sustained upregulation of Cluster 14 (igf2r、napin、vamp7、il1b、aco2) indicating functional maturation, while Cluster 29 (mcm10, espl1, cep152, cep44, cep295) confirms declining cell division activity. Collectively, this study provides a transcriptomic resource for understanding largemouth bass embryonic development and offers molecular insights for improving hatchery practices. - Source: PubMed
Publication date: 2026/08/31
Hua JixiangTao YifanSun HuiZhu TaideWang XiaoyiHuang XiaochenWang WenLu SiqiLu JianQiang Jun - Lysosomal storage disorders (LSDs) are intractable rare diseases caused by lysosomal dysfunction due mainly to defects in lysosomal enzyme genes. For many lysosomal enzymes to be transported correctly into lysosomes, their mannose-6-phosphate (M6P) labeling by GlcNAc-1 phosphotransferase (GNPT) is crucial. M6P-modified lysosomal enzymes are captured by M6P receptors and transported to lysosomes. The M6P-dependent pathway is utilized not only for newly synthesized lysosomal enzymes but also for the intracellular transport of exogenously administered lysosomal enzymes to lysosomes. In this study, we performed gene knockouts targeting the M6PR and IGF2R genes, which encode the M6P receptors. Cells with a double knockout of these genes secrete M6P-modified proteins into the culture supernatant (dKO sup), and we investigated its potential for therapeutic application. I-cell disease (mucolipidosis II, ML-II) arises from GNPT deficiency and is a disorder in which dozens of lysosomal enzymes are deficient within the cell. Treating ML II cells with the dKO sup restored lysosomal enzyme activity, reduced inclusion bodies, and improved autophagic function. ML II patient-derived fibroblasts exhibited increased lysosomal enzyme activities, normalized morphology, and improved cryo-viability with the treatment. NPC2 protein is not a lysosomal enzyme but functions cooperatively with NPC1 protein to mediate cholesterol transport in lysosomes. NPC2 deficiency causes Niemann-Pick disease type C2, and the dKO sup restored the cellular function of the disease by supplementing the NPC2 protein. These results indicate that M6PR/IGF2R double-deficient cells provide a simple platform for supplying M6P-modified proteins that can be applied to the treatment of a broad range of LSDs. - Source: PubMed
Publication date: 2026/08/28
Fujita ToshiharuTerawaki SeigoMoriwaki TakahitoOtomo Takanobu - Targeted protein degradation (TPD) enables selective elimination of disease-related proteins, including viral proteins. Here, we evaluated the antiviral potential of an IGF2-fused lysosomal targeting chimera (iLYTAC) in ZIKV- and IAV-infected models. We first confirmed that iLYTAC efficiently mediates uptake of extracellular proteins via the IGF2-IGF2R pathway and traffics to lysosomes. In combination with anti-E-cadherin antibody, iLYTAC reduced E-cadherin levels by 2-fold, indicating functional lysosomal targeting. For antiviral application, iLYTAC combined with non-neutralizing anti-ZIKV E IgG significantly reduced viral titers (10 to 10 PFU/mL), decreased viral RNA and protein levels, and promoted lysosomal colocalization of E protein, which was abolished by lysosome inhibition. In ZIKV-infected mice, iLYTAC combined with anti-E IgG reduced viral loads across tissues and blood, alleviated organ pathology and inflammation. Similarly, in H1N1-infected A549 cells, iLYTAC with non-neutralizing anti-HA IgG reduced cytopathic effects and viral titers, while selectively degrading HA via lysosomes without affecting NP. Overall, iLYTAC converts non-neutralizing antibodies into functional degraders of viral proteins, enabling effective suppression of infection and providing a potential platform for broad-spectrum antiviral therapeutics. - Source: PubMed
Publication date: 2026/08/20
Ma SaiyaZhang JieZhou SijieLi JingMa WenminYin XianzhengWang XiaochunTong Jie - Maternal high-fat diet (HFD) contributes to developmental programming through placental adaptations; however, the effects of exposure timing before and during pregnancy remain unclear. - Source: PubMed
Publication date: 2026/08/18
Lin Yu-JuCheng Yin-HuaTsai Ni-ChinTsai Ching-ChouTain You-LinYu Hong-RenLan Kuo-Chung