CD222
- Known as:
- CD222
- Catalog number:
- 11-315-C100
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD222
Related genes to: CD222
- Gene:
- IGF2R NIH gene
- Name:
- insulin like growth factor 2 receptor
- Previous symbol:
- -
- Synonyms:
- CD222, MPRI, MPR1, CIMPR, M6P-R, CI-M6PR, CI-MPR, MPR300
- Chromosome:
- 6q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1988-07-07
- Date modifiied:
- 2019-04-23
Related products to: CD222
Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1Antibodies: Mouse Monoclonal to CD222 _ IGF2 receptor _ CIMPR, Species Reactivity: Human, Non-Human Primates, Clone: MEM-238, Isotype: IgG1CD222 IGF2R antibody Ab host: RabbitCD222 IGF2R antibody Ab host: RabbitCD222 IGF2R antibody Ab host: RabbitCD222 IGF2R antibody Ab host: RabbitCD222 IGF2R antibody Ab host: Rabbit Related articles to: CD222
- Prostate cancer (PCa) is characterized by molecular heterogeneity and metabolic reprogramming, but the relationships among transcriptomic, proteomic, and metabolic signals remain incompletely defined. Here, we present a human-centered, cross-dataset analysis of public RNA, protein, and metabolomics data in PCa. We analyzed RNA and protein profiles from PC3 parental and drug-resistant cells together with an independent human matched tissue metabolomics dataset from Metabolomics Workbench (ST000784). RNA-protein overlap analysis identified seven genes that were significant at both layers, including five concordantly upregulated genes: UPP1, IGF2R, FLNC, DSP, and PLEC. Among these, UPP1 provided the most direct metabolic interpretation because it encodes uridine phosphorylase 1, an enzyme linked to pyrimidine salvage. Independent ST000784 matched prostate tissue metabolomics supported broader nucleotide metabolism remodeling, including significant changes in N-carbamoyl-L-aspartate, guanosine monophosphate, and adenosine 3,5-cyclic monophosphate. In contrast, uracil was not significantly altered and uridine 5'-monophosphate showed only a trend after multiple-testing correction. Repeated stratified cross-validation showed that UPP1-containing candidate gene sets achieved high within-layer AUC values in RNA and protein data, while nested statistical benchmark models also performed strongly. These results prioritize a UPP1-associated nucleotide remodeling hypothesis in PCa, but do not establish causal regulation of metabolite abundance or clinical diagnostic utility. Future matched multi-omics and perturbation experiments are required. - Source: PubMed
Publication date: 2026/07/31
Chen XuancaiSu WeiZhou QunQi YuchengXie JuanjuanTang YachunTang XinFu Hao - The somatotropic axis encompassing growth hormone (GH), insulin-like growth factor (IGF), myostatin (MSTN), and prolactin (PRL) signalling cascades is the master regulator of somatic growth, metabolism, and development in vertebrates. African catfish (Clarias gariepinus), a commercially pivotal aquaculture species, now possesses a chromosome-level reference genome (CGAR_prim_01v2); however, a systematic, genome-wide characterization spanning all five interconnected growth-related gene families has not previously been undertaken in this species. Here, we identified and characterized 15 growth-related genes spanning gh1, ghra, ghrb, Igf1, Igf2a, Igf2b, igf1ra, Igf1rb, Igf2r, Mstna, Mstnb, prl, prlra, prlrb, and smtlb distributed across 13 chromosomes. Complete one-to-one orthology with zebrafish confirmed strong dosage-balance conservation across >120 million years of teleost divergence. Physicochemical analysis resolved a clear biochemical dichotomy between compact, basic secreted ligands (19.88-45.81 kDa; pI up to 10.02) and large, acidic, heavily glycosylated membrane receptors (56.82-270.80 kDa; pI 4.85-5.97). Phylogenetic analysis confirmed 3R whole-genome duplication origins for all paralog pairs, while synteny analysis revealed a disruption of the ancestral gh1-prl chromosomal block in C. gariepinus, a finding that warrants further comparative and functional investigation. This genomic atlas provides the sequence and structural information including exon-intron boundaries, domain architecture, and chromosomal coordinates needed as a prerequisite for future marker-assisted selection and CRISPR-based myostatin-editing efforts in African catfish aquaculture, though translation into applied breeding outcomes will require subsequent functional and expression studies. - Source: PubMed
Publication date: 2026/07/22
Ja'afar YusufGhara SuvadipAjith NeethiRather Mohd Ashraf - Uremic cardiomyopathy (UCM) is a severe complication of uraemia that lacks effective treatments. The role of immune dysfunction in haemodialysis patients with UCM remains unclear. Peripheral blood mononuclear cells (PBMCs) are major components of the immune system; however, they do not directly contact cardiomyocytes. In general, extracellular vesicles (EVs) function as intercellular communication mediators. Therefore, in this study, we first investigated the role of PBMC-derived EVs (PBMC-EVs) in UCM and identified EV-miR-744-5p as a key molecule involved in PBMC-cardiomyocyte communication. Mechanistically, indoxyl sulphate (IS) downregulated miR-744-5p expression in PBMC-EVs, leading to IGF2R upregulation in cardiomyocytes, thereby exacerbating myocardial injury via induction of hypertrophy, apoptosis and inflammatory pathway activation in the cardiomyocytes. We also explored the potential of natural products to treat UCM by modifying PBMC-EVs and found that the traditional Chinese medicine monomer salvianolic acid B (Sal B) could bind to YY1, enhancing miR-744-5p expression in PBMC-EVs and thus mitigating myocardial injury in UCM. Taken together, these findings indicate the critical role of PBMC-EVs in UCM and suggest the cardioprotective effects of Sal B via PBMC-EV modification. They also provide novel insights into immune mechanisms underlying UCM, particularly indicating that targeting PBMC-EVs may be a promising UCM treatment strategy. - Source: PubMed
Wang ZiranHao JiaojiaoShang YaxiMa WenliWang NanWang WeidongTang QingzhuDu XiangningYang FanQin BiaojieChen ShuniXiao KunLi LongkaiGuo XiananQi XinMeng ShuangSong HuiyiLin Hongli - Immunoglobulins (e.g., IgGs) are critical effectors of the adaptive immune system that when overexpressed or dysregulated can result in autoimmune diseases. Thus, depletion of IgGs can be a promising therapeutic avenue. Here we developed g enetically- e ncoded lysosome targeting c himeras (GELYTACs) that target circulating IgGs for clearance and degradation. The GELYTACs comprised two protein modules derived from insulin-like growth factor 2 (IGF2) and an IgG-binding nanobody, respectively, and mediated clearance of plasma IgG via the lysosomal trafficking receptor IGF2R. To achieve long-lasting IgG depletion, we encoded GELYTACs in an AAV gene therapy vector and established continuous expression in mice. We also developed conditional GELYACs that are activatable with disease-specific proteases or small molecule drugs. This work establishes GELYTACs as a possible therapeutic modality that is deliverable using genetic medicine approaches. - Source: PubMed
Publication date: 2026/08/03
Yang Jonathan LeeLoh Kang YongSandoval Espinoza Cindy RSchuster DinaDeisseroth KarlBertozzi Carolyn R - Most of adrenocortical carcinomas (ACC) are characterized by IGF2 overexpression; therefore, several studies have focused on its two oncogenic effectors, the tyrosine-kinase receptors IGF1R and IR. However, the specific IGF2 receptor, IGF2R, due to its scavenging activity, was considered a tumour suppressor and has never been fully investigated in this context. Nevertheless, recent evidence from other tumours identified IGF2R as a pro-tumorigenic actor able to exert its function through the downstream activation of the pro-mitotic sphingosine kinases (SphK) enzymes responsible for sphingosine phosphorylation. Hence, the main aims of this study were to elucidate the role of IGF2R in ACC cells, investigate its action mechanism, and test IGF2R and SphK inhibitors as possible novel therapies for ACC. - Source: PubMed
Publication date: 2026/07/15
Nozza EmmaEsposito EmanuelaDi Bari SoniaCatalano RosaDi Muro GenesioBarbieri Anna MariaCassinotti ElisaPalmieri SerenaMangone AlessandraMorelli ValentinaTamburello MariangelaHantel ConstanzeLandwehr Laura-SophieDi Dalmazi GuidoFerrante EmanueleMantovani GiovannaPeverelli Erika