CD80
- Known as:
- CD80
- Catalog number:
- 1P-287-T025
- Product Quantity:
- 25 tests
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD80
Related genes to: CD80
- Gene:
- CD80 NIH gene
- Name:
- CD80 molecule
- Previous symbol:
- CD28LG, CD28LG1
- Synonyms:
- B7.1, B7-1
- Chromosome:
- 3q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1993-12-14
- Date modifiied:
- 2016-10-05
Related products to: CD80
Activation B7-1 antigen,B7,B7,Cd80,Mouse,Mus musculus,T-lymphocyte activation antigen CD80Activation B7-1 antigen,B7,BB1,CD28LG,CD28LG1,CD80,CTLA-4 counter-receptor B7.1,Homo sapiens,Human,LAB7,T-lymphocyte activation antigen CD80Activation B7-1 antigen,CD80,Oryctolagus cuniculus,Rabbit,T-lymphocyte activation antigen CD80anti-CD80anti-CD80anti-CD80anti-CD80anti-CD80anti-CD80 (1G1)anti-CD80 (3D7)anti-CD80 (3E10)anti-CD80 (4A4)anti-CD80 (1G1)anti-CD80 (1G1) type: Primary antibodies host: Mouseanti-CD80 (2A2) Related articles to: CD80
- Bacillus Calmette-Guérin (BCG) remains the only licensed vaccine for tuberculosis (TB), yet its efficacy wanes over time due to insufficient durability of vaccine-induced immunity. However, mechanisms constraining BCG vaccine-induced dendritic cell (DC)-mediated T cell priming are poorly understood. Cholesterol 25-hydroxylase (CH25H) converts cholesterol into 25-hydroxycholesterol (25-HC) that modulates antigen-presenting cell imprinting and innate immune responses. Here, we investigated whether CH25H regulates DC function and vaccine-induced protective immunity against (Mtb). We found that CH25H deficiency enhanced DC activation, characterized by increased expression of the costimulatory molecules CD80 and CD86, elevated interleukin (IL)-12p70 production, and reduced IL-10 secretion, resulting in augmented T cell proliferation and robust Th1 cytokine responses. Transcriptomic analyses of CH25H-deficient and 25-HC-treated DCs showed that an SREBP2-associated program may contribute to expression. BCG vaccination conferred enhanced protection in mice, including reduced Mtb burden and pulmonary inflammation. BCG-vaccinated mice developed more durable protective immunity and increased frequencies of CD103CD69 tissue-resident memory T cells, along with sustained IL-2-producing T cell responses. Collectively, these findings identify CH25H as a negative regulator of DC-mediated Th1 immunity and suggest that targeting CH25H represents a potential host-directed immunomodulatory strategy to enhance the long-term protective immunity of TB vaccination. - Source: PubMed
Publication date: 2026/09/30
Kim HagyuChoi EunsolKwon Kee WoongChoi Hong-HeeKim KyungminJung WeonSeokShin Sung Jae - Δ-Tetrahydrocannabinol (THC), the primary psychoactive component of cannabis, has been reported to modulate immune responses; however, its effects on complex innate immune signaling pathways and inflammation remain incompletely understood. Here, we investigated the immunomodulatory effects of THC on lipopolysaccharide (LPS)-induced inflammation across cellular and models. - Source: PubMed
Publication date: 2026/09/16
Tomer ShalluHarding JeffreyWang LiKedia NanditaCook EthanLe VincentPlatt ChristopherLe JonathanTien NicholasPatalay KanishkhLangfelder PeterYang X WilliamZhang YeZhen Anjie - Cancer immunotherapy has shown considerable promise, particularly through dendritic cell (DC)-based vaccines, which are capable of inducing potent, durable, and tumor-specific immune responses. However, their clinical efficacy remains limited by the immature phenotype of DCs, inefficient antigen presentation, and the immunosuppressive tumor microenvironment. - Source: PubMed
Publication date: 2026/09/24
Eteghadi AtefehTaghipour NiloofarHosseinzadeh SimzarHashemi Seyed MahmoudGhasemi Fatemeh SadatSoleimani Masoud - Pectic polysaccharides from medicinal plants are promising natural immunomodulators, but their structural heterogeneity has hindered the identification of bioactive domains and limited their further development. The structural basis underlying their regulation of dendritic cell-mediated immune responses remains poorly understood. - Source: PubMed
Publication date: 2026/09/28
Xu YongbinGuo MengyaLiu YupengChen JieShi SongshanShi ChenchenWang ShunchunWang Huijun - Gonorrhea remains one of the most prevalent sexually transmitted infections globally, with an estimated 82-87 million new infections annually and no licensed vaccine available. Antigenic variability and the lack of durable protective immunity following natural infection have been major obstacles to vaccine development. We previously developed an adjuvanted, formalin-inactivated whole-cell gonococcal microparticle (GC-MP) vaccine delivered by dissolving microneedles and demonstrated that it induced functional antibodies and enhanced bacterial clearance in murine models. Here, we evaluated this GC-MP microneedle platform in to provide proof-of-concept data in a relevant large-animal model and to compare different adjuvants. were allocated into five groups and vaccinated, and serum antigen-specific IgG and IgA responses were quantified by ELISA, with functional activity assessed by serum bactericidal assay. In parallel, the potency of delta-inulin-, aluminum-phosphate-, or aluminum-hydroxide-adjuvanted -loaded microparticles to activate dendritic cells was assessed in vitro via changes in surface expression of MHC I, MHC II, CD40, and CD80. The serum from vaccinated primates demonstrated elevated gonococcal-specific IgG and IgA responses compared with naïve controls and measurable bactericidal activity against live, homologous strains. All adjuvanted formulations increased dendritic cell expression of MHC I, MHC II, CD40, and CD80. These findings indicate that an adjuvanted whole-cell inactivated gonorrhea vaccine delivered transdermally via microneedles elicits clearly elevated, relative to controls, functional antibody responses, supporting its advancement toward clinical evaluation. - Source: PubMed
Publication date: 2026/09/20
Ferguson AmaraeHarsoda YashkumarPasupuleti DedeepyaArte Tanisha ManojBagwe PriyalGulani MahekAdediran EmmanuelUddin MohammadPetrovsky NikolaiD'Souza Martin JZughaier Susu M