CD147
- Known as:
- CD147
- Catalog number:
- 11-274-C100
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD147
Related genes to: CD147
- Gene:
- BSG NIH gene
- Name:
- basigin (Ok blood group)
- Previous symbol:
- OK
- Synonyms:
- EMMPRIN, CD147, EMPRIN
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-25
- Date modifiied:
- 2019-04-23
Related products to: CD147
Related articles to: CD147
- Adipocyte dysfunction is closely associated with oxidative stress and chronic inflammation, which contribute to systemic metabolic disturbances and atherosclerosis. We previously identified the NKA (Na/K-ATPase) α1 subunit as a signal transducer that activates Src-family kinases and promotes oxidative stress and inflammation in various cell types, including adipocytes and macrophages. NaKtide, a peptide inhibitor of NKA signaling, has been shown to reduce systemic oxidative stress and inflammation in vivo. In this study, we investigated the role of adipocyte-specific NKA signaling in atherosclerosis. - Source: PubMed
Publication date: 2026/08/27
Goncalves Bruno SWang YaxinPillai Sneha SLuu Quoc QuangTriniac HortenseLakhani Hari VChaudhry Muhammad AZheng ZeShapiro Joseph ISilverstein Roy LSodhi KomalChen Yiliang - Glioblastoma (GBM) is widely recognised as a highly aggressive form of malignant tumour arising within the central nervous system. The proneural-to-mesenchymal (PN-MES) state transition is a key process underlying malignant progression and therapeutic resistance. The present study was designed to elucidate the association between the PN-MES transition and arachidonic acid (AA) metabolic reprogramming in GBM. We integrated four public single-cell RNA-sequencing cohorts, two spatial transcriptomic cohorts, and three bulk RNA-sequencing cohorts for GBM. By combining single-cell transcriptomics, spatial transcriptomics, pseudotime trajectory inference, and cell-cell communication analysis, we systematically evaluated the cell-state dependence and spatial heterogeneity of AA metabolism in GBM. We further incorporated machine learning-based survival modelling, molecular docking, molecular dynamics simulations, and in vitro functional assays to identify and validate potential prognostic biomarkers and therapeutic targets. Mesenchymal-like (MES-like) tumour cells showed the highest transcriptionally inferred AA metabolism-related score, and AA metabolism-related gene expression was closely coupled with PN-MES state transition. The peptidylprolyl isomerase A ()-basigin () signalling axis was selectively enriched in tumour cells with high expression of arachidonic acid metabolism-related genes (AAMGs), whereas virtual knockout of perturbed MES- and invasion-related gene modules. Spatial transcriptomic analysis confirmed that --associated communication was enhanced within MES-like tumour niches and was coupled with inflammatory and hypoxic programmes. AA metabolism-related genes enabled robust prognostic stratification. Molecular simulation and in vitro experiments suggested that Venetoclax could bind and suppress GBM cell viability. AA metabolism-related transcriptional reprogramming defines mesenchymal-associated malignant niches in GBM and may contribute to PN-MES-related state evolution through --mediated microenvironmental communication. AA metabolism-related features and the -associated signalling axis may provide candidate directions for prognostic stratification and targeted intervention. - Source: PubMed
Publication date: 2026/08/01
Peng ShiyunWen ZhenkunCai Xiao-Ting - Intraoperative neurophysiological monitoring (IONM) is widely used during brainstem surgery to reduce the risk of neurological injury, although its prognostic value in adult brainstem glioma (BSG) surgery remains unclear. We retrospectively analyzed 22 consecutive adults who underwent surgery for BSGs with multimodal IONM between 2010 and 2023. Monitoring included somatosensory evoked potentials (SSEPs), motor evoked potentials (MEPs), brainstem auditory evoked potentials (BAEPs), corticobulbar MEPs (CoMEPs), and cranial nerves electromyography. The primary endpoint was the association between intraoperative neurophysiological changes and postoperative neurological functional status at hospital discharge, assessed with the modified McCormick Scale (mMCS). Secondary endpoints included postoperative complications and length of hospital stay. SSEP warning criteria were met in 10 patients (45.5%), while 10 patients (45.5%) experienced a ≥50% reduction in MEP amplitude in at least one monitored muscle. Despite these findings, neither SSEP nor MEP amplitude changes were significantly associated with postoperative neurological status. Transcranial MEP stimulation thresholds increased significantly during surgery ( = 0.007), and threshold elevation was associated with postoperative complications (Kendall's τ = 0.498, = 0.007). BAEP recordings remained stable throughout all procedures. Conventional amplitude-based IONM changes were not associated with early neurological outcome after adult BSG resection. In contrast, increases in MEP stimulation threshold may represent a sensitive indicator of postoperative complications. Further prospective studies are warranted. - Source: PubMed
Publication date: 2026/08/15
Pauletto GiadaSkrap BenjaminTomasino BarbaraLettieri ChristianEcoretti ElisaSkrap MiranLandi AndreaDenaro LucaVindigni MarcoRobiony MassimoValente MariarosariaIus TamaraVerriello Lorenzo - Advanced rectal lesions (ARLs), including large laterally spreading lesions (LSLs), villous or high-grade dysplastic adenomas, and early rectal cancers, constitute a critical transitional category between benign adenoma and invasive carcinoma. Historically, radical surgery was liberally employed for these lesions, often resulting in significant morbidity and permanent stoma formation. Contemporary endoscopic and transanal techniques permit curative resection while preserving anorectal function, but careful assessment is mandatory to avoid undertreatment of covert cancers. - Source: PubMed
Publication date: 2026/06/11
Eitan MayanBurgess Nicholas G - To maximize the recovery of multiple added-value products from biomass waste streams, optimal valorization should follow a cascade process integrating extraction and conversion steps. In this context, natural deep eutectic solvents (NADES) can be employed as green solvents to significantly expand the possible valorization routes. In this study, brewer's spent grain (BSG) was first used for antioxidant (polyphenolic compound) extraction with NADES, whereupon the remaining biomass was converted into activated carbons (ACs). These adsorbents were characterized in-depth, and their performance for subsequent NADES clean-up is described for the first time as a proof-of-concept. Extraction with NADES caused a significant reduction in AC yield, due to associated degradation effects on structural elements (lignin, cellulose, and hemicellulose) within the biomass. The largest effect (only 3% AC yield for choline chloride:malic acid) was correlated to the solvent acidity, and not inherent to the NADES hydrogen bond interactions. In addition, the acidic pretreatment caused significantly lower surface area and less micropore development, which negatively impacted the adsorption properties. Nonetheless, NADES pretreatments created ACs that outperform traditional woody-biomass-derived commercial AC reference materials (adsorption q of 203.9 ± 12.5, 257.3 ± 6.8, and 204.9 ± 2.8 mg/g, respectively, from choline chloride:glycerol NADES stock solution). - Source: PubMed
Bleus DriesGhanemnia NahalMarchal WouterVandamme Dries