CD147
- Known as:
- CD147
- Catalog number:
- 11-274-C025
- Product Quantity:
- 0.025 mg
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD147
Related genes to: CD147
- Gene:
- BSG NIH gene
- Name:
- basigin (Ok blood group)
- Previous symbol:
- OK
- Synonyms:
- EMMPRIN, CD147, EMPRIN
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-25
- Date modifiied:
- 2019-04-23
Related products to: CD147
Related articles to: CD147
- A holistic biorefinery concept integrating cell wall deconstruction, downstream separation and purification steps to convert brewers' spent grains (BSG) into high-value fractions was developed using alkali and deep eutectic solvents. Protein and arabinoxylan yields significantly increased with ultrasound (US) pretreatment, reaching 21% and 27% (w/w) of starting dry BSG, respectively. Protein purity reached 67% with 58% recovery efficiency, and arabinoxylans achieved 90% purity with 94% recovery efficiency using conventional sodium hydroxide (NaOH). Furthermore, the branched structure of arabinoxylans was preserved in NaOH biorefining with an arabinose/xylose ratio > 0.4. However, choline chloride maleic acid (CCM) selectively cleaved side-chain acyl substitutions, identified in phenolic fractions as 5-O-trans-p-coumaroyl-l-arabinofuranose and 5-O-trans-p-feruloyl-l-arabinofuranose. Consequently, linear monodispersed xylopyranose homopolymers and low molecular weight xylo-oligosaccharides were produced with higher phenolic yield than conventional biorefining. Holistic biorefinery concepts demonstrated the potential to extensively valorise BSG into a cascade of high-value products, promoting circular bio-economy principles through waste-to-value conversion. - Source: PubMed
Publication date: 2026/09/28
Nkurunziza DavidPukala TaraBulone VincentCoad Bryan R - Mitophagy, a selective form of autophagy, has been implicated in tumor progression and therapeutic resistance; however, its prognostic significance in hepatocellular carcinoma (HCC) remains unclear. In this study, we comprehensively evaluated the role of mitophagy-related genes in HCC using multi-omics data. Gene expression profiles were obtained from the TCGA-LIHC and GSE14520 cohorts, and mitophagy-related genes were retrieved from the GeneCards database. Twenty differentially expressed mitophagy-related genes with prognostic value (pDEMGs) were identified, and consensus clustering stratified HCC patients into two clusters with significantly different survival outcomes (P = 0.001). A mitophagy enrichment score (MIES) was then calculated using single-sample gene set enrichment analysis (ssGSEA). Elevated MIES was associated with poorer overall survival (HR = 2.17, P = 0.005), metabolic activation, immune suppression, and differential drug sensitivity. Single-cell analysis of the GSE140228 dataset revealed heterogeneous MIES activity across cell populations, with relatively higher enrichment observed in proliferating T cells and dendritic cells. A six-gene prognostic signature (ACTR6, GAPDH, ATIC, ANP32E, CCT6A, and BSG) was developed using LASSO-Cox regression, which effectively stratified patients into high- and low-risk groups with distinct overall survival outcomes (1-, 3-, and 5-year AUCs: 0.780, 0.682, and 0.690, respectively). The risk score was correlated with immune infiltration patterns, mutational landscape, and chemotherapy response. qPCR validation further confirmed the upregulation of ACTR6, CCT6A, ATIC, and BSG in HCC cells. Collectively, these findings establish a mitophagy-related scoring system that reflects immune and genomic characteristics, as well as a six-gene signature with independent prognostic value, highlighting the potential clinical relevance of mitophagy in HCC. - Source: PubMed
Publication date: 2026/09/30
Luo HanYang YiWen JingyuHou Yifu - Endoscopy units are faced with increasing procedural demand; while staffing, space, and budgets are not. Lasting gains in efficiency rarely come from a single intervention; rather, they come from working on several fronts at once, from unit design and scheduling through to staffing, sedation choice, technology, and quality governance. We set out to bring the evidence on this for the working endoscopist, or unit manager can use. We conducted a narrative review of the literature published between 2000 and 2025, searching PubMed, Embase, and the Cochrane database with terms including "endoscopy efficiency," "endoscopy scheduling," "endoscopy quality improvement," "Lean endoscopy," "plan-do-study-act (PDSA) endoscopy," and "endoscopy key performance indicators (KPIs)." We supplemented this with consensus statements and quality measures from the American Society for Gastrointestinal Endoscopy (ASGE), the European Society of Gastrointestinal Endoscopy (ESGE), and the British Society of Gastroenterology (BSG). Eight inter-related domains were identified: meaningful KPI measurement, physical design that supports patient flow, evidence-based scheduling, lean and PDSA-driven workflow change, staffing models matched to case mix, procedure-level sedation choices, targeted technology, and quality benchmarking. In individual published series, reported gains are substantial: PDSA-based interventions increased procedural volume by up to 18% and reduced mean first-case delay by 15.5 min. Lean redesign can reduce room turnover from 28 to 18 minutes and daily cases per room from 9 to 12. Scheduling optimization can improve room utilization from below 70% to above 85% in published quality improvement series. Endoscopy efficiency needs careful metric selection, a layout that improves patients, experience, intelligent rostering, ongoing process work, flexible staffing, sensible sedation, the right technology in the right places, and honest benchmarking. The frameworks set out in this review are intended to give units of any size a starting point. - Source: PubMed
Publication date: 2026/09/24
Alshankiti SulimanAlotaibi AmmarMubarak Muhammad FAlkhiari RasheedAlmadi Majid A - Brewer's spent grain (BSG) is an abundant agro-industrial by-product with potential for manufacturing sustainable particleboards, although its relatively low cellulose content limits the mechanical performance of the resulting boards. In this study, particleboards were produced from BSG using a soybean protein concentrate (SPC)-based adhesive at three adhesive contents. In addition, rosin surface coating and wood veneer reinforcement were investigated as strategies to improve the performance of the boards. Physical and mechanical properties were evaluated according to American and European standards, while X-ray micro-computed tomography was used to analyze the structure of the panels. Increasing the SPC content significantly improved all mechanical and physical properties. Rosin coating further reduced water absorption and moisture diffusivity while improving the modulus of rupture, modulus of elasticity, and internal bond strength. X-ray micro-CT analysis revealed local density increases associated with rosin penetration into the board structure. The greatest improvement was achieved with wood veneer reinforcement particleboards, satisfying the H1-ANSI A208.1 and P2-EN312 minimum flexural requirements. Moreover, Digital Image Correlation (DIC) revealed that wood veneer reinforcement significantly altered the deformation and failure mechanisms. These results demonstrate that simple surface reinforcement strategies enable the production of bio-based particleboards with significantly improved performance. - Source: PubMed
Publication date: 2026/09/20
Rossi LuciaRueda FedericoCiannamea Emiliano MStefani Pablo M - Brewer's spent grain (BSG) is the primary by-product of the brewing industry and a low-cost lignocellulosic resource rich in phenolics, proteins, and arabinoxylans (AXs). Conventional recovery methods using acids, alkalis, and organic solvents often involve energy-intensive processes, generate hazardous waste, and limit food-grade applications. This review critically examines the evolution of extraction methodologies for BSG bioactives, highlighting the potential of deep eutectic solvents (DES) as sustainable alternatives. Key factors such as solvent chemistry (polarity, pH, and water content) influence bioactives' recovery and selectivity. Process intensification techniques such as ultrasound, microwave, and pressurised liquid extraction enhance efficiency by reducing extraction time and temperature. The review assesses how various processes modify the structure-function properties of BSG bioactives, including antioxidant activity, protein functionality, and rheological behaviour. A significant finding is that DES research has primarily focused on single compounds, while integrated DES biorefineries for comprehensive valorisation remain underexplored. Future research should therefore prioritise integrated process design that balances recovery, structural preservation, functionality, and sustainability to support scalable, near-zero-waste BSG valorisation for food and nutraceutical applications. - Source: PubMed
Publication date: 2026/09/08
Hossain Mohammad AfzalLobel Benjamin TCurrie Andrew JStathopoulos CostasChockchaisawasdee Suwimol