CD147
- Known as:
- CD147
- Catalog number:
- 11-274-C025
- Product Quantity:
- 0.025 mg
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD147
Related genes to: CD147
- Gene:
- BSG NIH gene
- Name:
- basigin (Ok blood group)
- Previous symbol:
- OK
- Synonyms:
- EMMPRIN, CD147, EMPRIN
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-25
- Date modifiied:
- 2019-04-23
Related products to: CD147
Related articles to: CD147
- Ustilago maydis is an emerging microbial host for the sustainable production of itaconic acid, an important platform chemical. Its robustness toward impurities and compatibility with renewable resources make it an attractive alternative to the industrial producer Aspergillus terreus. Here, a detailed protocol for converting brewer's spent grains (BSG), an exemplary lignocellulosic feedstock, into itaconic acid using U. maydis is presented. The workflow describes an extended valorization route, integrating pretreatment, fermentation, and analysis. The solid fraction of BSG undergoes organosolv pretreatment to enhance enzymatic accessibility, while the liquid fraction from pretreatment is recovered and detoxified for potential fermentation use. Nitrogen availability is assessed to account for its key role in triggering secondary metabolism. Simultaneous saccharification and fermentation (SSF) is then applied, enabling continuous sugar release and conversion into itaconic acid. The protocol further details analytical methods, including HPLC for substrates, products, and inhibitors, as well as fluorescence microscopy-based cell counting for biomass monitoring. - Source: PubMed
Laudensack WolfgangWeiermüller JensUlber Roland - Bridging stent grafts (BSG) are a critical component of fenestrated and branched endovascular aortic repair (f/bEVAR) but remain prone to structural failure due to continuous biomechanical stress. Early detection of stent wire fractures is clinically relevant, yet remains challenging with conventional computed tomography (CT) because of limited effective spatial resolution and metal-related blooming artifacts. The aim of the study is to evaluate whether photon-counting detector CT (PCCT) improves the detectability of structural defects in BSG compared with dual-energy CT (DECT). - Source: PubMed
Publication date: 2026/09/01
Kern MaximilianDachs Theresa MStrassl AndreasHauck Sven RHoffner Maximilian KKlausenitz CatharinaLange CarlottaHannover AlbertFunovics Martin A - Adipocyte dysfunction is closely associated with oxidative stress and chronic inflammation, which contribute to systemic metabolic disturbances and atherosclerosis. We previously identified the NKA (Na/K-ATPase) α1 subunit as a signal transducer that activates Src-family kinases and promotes oxidative stress and inflammation in various cell types, including adipocytes and macrophages. NaKtide, a peptide inhibitor of NKA signaling, has been shown to reduce systemic oxidative stress and inflammation in vivo. In this study, we investigated the role of adipocyte-specific NKA signaling in atherosclerosis. - Source: PubMed
Publication date: 2026/08/27
Goncalves Bruno SWang YaxinPillai Sneha SLuu Quoc QuangTriniac HortenseLakhani Hari VChaudhry Muhammad AZheng ZeShapiro Joseph ISilverstein Roy LSodhi KomalChen Yiliang - Glioblastoma (GBM) is widely recognised as a highly aggressive form of malignant tumour arising within the central nervous system. The proneural-to-mesenchymal (PN-MES) state transition is a key process underlying malignant progression and therapeutic resistance. The present study was designed to elucidate the association between the PN-MES transition and arachidonic acid (AA) metabolic reprogramming in GBM. We integrated four public single-cell RNA-sequencing cohorts, two spatial transcriptomic cohorts, and three bulk RNA-sequencing cohorts for GBM. By combining single-cell transcriptomics, spatial transcriptomics, pseudotime trajectory inference, and cell-cell communication analysis, we systematically evaluated the cell-state dependence and spatial heterogeneity of AA metabolism in GBM. We further incorporated machine learning-based survival modelling, molecular docking, molecular dynamics simulations, and in vitro functional assays to identify and validate potential prognostic biomarkers and therapeutic targets. Mesenchymal-like (MES-like) tumour cells showed the highest transcriptionally inferred AA metabolism-related score, and AA metabolism-related gene expression was closely coupled with PN-MES state transition. The peptidylprolyl isomerase A ()-basigin () signalling axis was selectively enriched in tumour cells with high expression of arachidonic acid metabolism-related genes (AAMGs), whereas virtual knockout of perturbed MES- and invasion-related gene modules. Spatial transcriptomic analysis confirmed that --associated communication was enhanced within MES-like tumour niches and was coupled with inflammatory and hypoxic programmes. AA metabolism-related genes enabled robust prognostic stratification. Molecular simulation and in vitro experiments suggested that Venetoclax could bind and suppress GBM cell viability. AA metabolism-related transcriptional reprogramming defines mesenchymal-associated malignant niches in GBM and may contribute to PN-MES-related state evolution through --mediated microenvironmental communication. AA metabolism-related features and the -associated signalling axis may provide candidate directions for prognostic stratification and targeted intervention. - Source: PubMed
Publication date: 2026/08/01
Peng ShiyunWen ZhenkunCai Xiao-Ting - Intraoperative neurophysiological monitoring (IONM) is widely used during brainstem surgery to reduce the risk of neurological injury, although its prognostic value in adult brainstem glioma (BSG) surgery remains unclear. We retrospectively analyzed 22 consecutive adults who underwent surgery for BSGs with multimodal IONM between 2010 and 2023. Monitoring included somatosensory evoked potentials (SSEPs), motor evoked potentials (MEPs), brainstem auditory evoked potentials (BAEPs), corticobulbar MEPs (CoMEPs), and cranial nerves electromyography. The primary endpoint was the association between intraoperative neurophysiological changes and postoperative neurological functional status at hospital discharge, assessed with the modified McCormick Scale (mMCS). Secondary endpoints included postoperative complications and length of hospital stay. SSEP warning criteria were met in 10 patients (45.5%), while 10 patients (45.5%) experienced a ≥50% reduction in MEP amplitude in at least one monitored muscle. Despite these findings, neither SSEP nor MEP amplitude changes were significantly associated with postoperative neurological status. Transcranial MEP stimulation thresholds increased significantly during surgery ( = 0.007), and threshold elevation was associated with postoperative complications (Kendall's τ = 0.498, = 0.007). BAEP recordings remained stable throughout all procedures. Conventional amplitude-based IONM changes were not associated with early neurological outcome after adult BSG resection. In contrast, increases in MEP stimulation threshold may represent a sensitive indicator of postoperative complications. Further prospective studies are warranted. - Source: PubMed
Publication date: 2026/08/15
Pauletto GiadaSkrap BenjaminTomasino BarbaraLettieri ChristianEcoretti ElisaSkrap MiranLandi AndreaDenaro LucaVindigni MarcoRobiony MassimoValente MariarosariaIus TamaraVerriello Lorenzo