CD47
- Known as:
- CD47
- Catalog number:
- 1F-225-T100
- Product Quantity:
- 100 tests
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD47
Related genes to: CD47
- Gene:
- CD47 NIH gene
- Name:
- CD47 molecule
- Previous symbol:
- MER6
- Synonyms:
- IAP, OA3
- Chromosome:
- 3q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-12
- Date modifiied:
- 2016-10-05
Related products to: CD47
Related articles to: CD47
- CD200 and its receptor CD200R form a myeloid-centered immune checkpoint that normally restrains myeloid activation and limits tissue damage, but many solid tumors co-opt this pathway to suppress antitumor immunity. CD200-CD200R signaling is highly context-dependent, varying even among models of the same cancer type. In melanoma and breast carcinoma, it can either suppress protumor inflammation or promote tumor growth and metastasis depending on the model, whereas in neuroblastoma; glioblastoma and other central nervous system tumors; cutaneous and head and neck squamous cell carcinoma; colorectal cancer; and several endocrine, ovarian, and pancreatic cancers, it consistently suppresses macrophage, dendritic cell, natural killer cell, and CD8+ T-cell activation, impairs phagocytosis and antigen presentation, and drives immunosuppressive infiltration. Non-small cell lung cancer and renal cell carcinoma emerge as two additional, less-characterized but clinically important contexts warranting further investigation. CD200R1-CD200 has also recently been identified as a macrophage phagocytosis checkpoint that functions independently of CD47-SIRPα, placing it within the expanding family of innate immune checkpoints. Rather than treating CD200-CD200R as a universally protumorigenic target, we propose a context-dependent framework-incorporating tumor type, microenvironmental architecture, and dominant myeloid and lymphoid programs-to guide tumor-specific therapeutic strategies in solid cancers. - Source: PubMed
Publication date: 2026/09/18
Sahu Manas RanjanEzhil InemaiAkkanapally VenuKumar AmanLiu Jin-QingBasu Sujit - Overground movement in mammals requires the assembly and refinement of sensory-motor circuits to ensure proper motor control. Although, supernumerary synapses are formed and subsequently pruned in the brain, whether this occurs within spinal sensory-motor circuits remains unclear. Moreover, it is unknown what molecules are involved. Here, we demonstrate the presence of proprioceptive supernumerary synapses forming inappropriate contacts with motor neurons, resulting in miswired immature circuits. Using mouse genetics, neuronal circuit mapping, electrophysiology, and behavioral studies, we demonstrate that the inappropriate synapses are functional, leading to impaired behaviors. We further identify two complementary mechanisms responsible for their elimination: first, C3 through the classical complement pathway and second, CD47 that operates independently of classical complement signaling. This finding underlies an unexpected function for CD47 within the spinal cord, in contrast to its function in the brain. Thus, during early development, the course of elimination of inappropriately generated synapses utilizes a dual fail-safe system to ensure emergence of mature spinal motor circuits. - Source: PubMed
Publication date: 2026/09/16
Florez-Paz DannyMentis George Z - Upon entry into the bloodstream, nanocarriers can be rapidly cleared by the mononuclear phagocyte system (MPS), limiting their clinical translation. In this study, based on the CD47-SIRPα "don't eat me" signaling pathway, we functionalized human serum albumin (HSA) with peptides (SP1) truncated from CD47. Ortho-nitrobenzyl alcohol (o-NBA) was used as a photoreactive handle to modify SP1, and a subsequent photocatalysis gave rise to SP1-HSA conjugates (multi-HSA) with the peptide being multivalently displayed on the albumin. For comparison, a monovalent conjugate (mono-HSA) was prepared via a site-specific thiol-maleimide chemistry at Cys34. Both conjugates were loaded with chlorin e6 (Ce6) for in vitro evaluation and indocyanine green (ICG) for in vivo imaging. We found that multi-HSA@Ce6 reduced macrophagic uptake by ∼8-fold with respect to mono-HSA@Ce6, demonstrating the effectiveness of multivalency. Competitive binding and SIRPα-knockdown assays validated that the CD47-SIRPα signaling pathway mediated the attenuation of macrophagic uptake. In vivo biodistribution studies revealed that multi-HSA@ICG reduced hepatic uptake by ∼2-fold and significantly prolonged blood circulation with respect to unmodified HSA@ICG. This work establishes a facile and effective photocatalytic approach for the construction of multivalent peptide-protein conjugates capable of escaping from phagocytic clearance for drug delivery applications. - Source: PubMed
Publication date: 2026/09/15
Huang HailingChen Ting-XuanXu BowenYu YongHe HuisiYi QiuyunZhang Hong-YangHu Xi-LeHe Xiao-PengWen Wen - Hypoxia (pO2 < 5-10 mmHg) is a critical feature of the tumor environment that causes genetic and epigenetic changes. This study aimed to evaluate the effect of hypoxia on the expression of immune checkpoint genes (CD39, CD47, and PD-L1) and their regulatory microRNAs (miRNAs; miR-155, miR-424, miR-133, miR-142) in the gastric cancer cell line MKN-45. - Source: PubMed
Publication date: 2026/06/21
Samemaleki SaharOrooji NiloufarKazemi TohidSolgi Ghasem - Ovarian folliculogenesis relies on tightly coordinated communication between the oocyte and surrounding granulosa cells, yet how this molecular dialogue is remodeled during follicle development remains poorly understood. Here, we reconstructed stage-specific ligand-receptor communication networks through a transcriptomic meta-analysis integrating bovine secondary, early antral, and middle antral follicles. Our analyses revealed that oocyte-granulosa cell communication undergoes progressive remodeling during folliculogenesis, with distinct signaling programs characterizing successive developmental stages. Secondary follicles were predominantly associated with extracellular matrix organization, cell adhesion, and early metabolic regulation. During the early antral stage, signaling shifted toward lipid, steroid, and vitamin metabolism, identifying this phase as a major metabolic transition. Middle antral follicles exhibited a marked increase in communication complexity, with enrichment of PI3K-AKT, mTOR, RAS, Hippo, and cell adhesion pathways accompanying the acquisition of developmental competence. Additional analyses of Brilliant Cresyl Blue-classified cumulus-oocyte complexes identified competence-associated ligand-receptor interactions, while independent validation using the EmbryoGENE dataset confirmed stage-specific expression patterns and highlighted CD47, FGF21, and GPC6 as candidate regulators of oocyte developmental competence. This study provides a comprehensive transcriptomic framework describing the dynamic remodeling of oocyte-granulosa cell communication during bovine folliculogenesis. Beyond confirming established signaling pathways, it identifies novel candidate interactions and offers a biologically grounded resource to guide future functional studies and the optimization of in vitro follicle and cumulus-oocyte complex culture systems. - Source: PubMed
Monferini NoemiDonadini LudovicaDey PrithaFranciosi FedericaLodde ValentinaRabaglino Maria BelenLuciano Alberto Maria