Ask about this productRelated genes to: STOM antibody
- Gene:
- STOM NIH gene
- Name:
- stomatin
- Previous symbol:
- EPB7, EPB72
- Synonyms:
- BND7
- Chromosome:
- 9q33.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-09-14
- Date modifiied:
- 2016-10-05
Related products to: STOM antibody
Related articles to: STOM antibody
- Stomatin is a ubiquitous and highly expressed protein in erythrocytes, which associates with cholesterol-rich microdomains in the plasma membrane and is known to regulate the activity of multiple ion channels and transporters, but the structural basis of association with stomatin targets remains unknown. Here, we describe high-resolution structures of multiple stomatin complexes with endogenous binding partners isolated from human erythrocyte membranes, revealing that stomatin specifically associates with two membrane proteins involved in water transport and cell volume regulation, aquaporin-1 and the urea transporter SLC14A1. Together, our results reveal the structural basis of stomatin oligomerization, membrane association, and target recruitment and identify a putative role for stomatin in the regulation of osmotic balance in the erythrocyte. - Source: PubMed
Publication date: 2026/04/01
Vallese FrancescaLi HuanBarazzuol LuciaCalì TitoClarke Oliver B - Maxillary sinus floor elevation is a well-established procedure for increasing bone volume in the posterior maxilla, yet the regenerative outcome depends strongly on the choice of grafting material. This clinical study compared a high-temperature sintered xenograft (Bio-Oss) and a low-temperature processed xenograft (Ti-Oss) with regard to their regenerative and immunological profiles. - Source: PubMed
Korzinskas TadasSchnettler ReinerRimashevskiy DenisMalik BirzhanDakenov BaurzhanBagdoniene DianaJung OleBarbeck Mike - Plant-microbe interactions regulate soil greenhouse gas (GHGs) fluxes, yet their responses to climate extremes remains unclear. In a factorial experiment combining plant composition (bare soil, monoculture, intercropping) with contrasting temperatures, we found that the soil global warming potential (GWP) mitigation effect of intercropping under extreme high temperature (EHT) significantly declined by 17.4 % compared with normal temperature (LT). EHT suppressed plant biomass (-41.9 % to -86.6 %), diminished soil carbon sequestration (-0.9 % to -6.9 %), and increased the r/K strategy ratios (+0.7 % to +5.7 %). It further erased the clear separation between intercropping and monoculture microbial communities evident under LT and upregulated key N-loss genes (e.g., nirS, norC), jointly undermining the microbial basis of plant-mediated GHGs mitigation. Our findings highlight that while plant diversity stabilizes soil biogeochemistry and constrains GHGs release, its buffering efficacy is inherently fragile under EHT, providing new evidence of limits to biotic regulation in a warming world. - Source: PubMed
Publication date: 2025/12/16
Zhang XiangWei LimanYang ChangmingZhao QiongStom Devard ILi TianZhou Qixing - Remediation of aged petroleum hydrocarbon (A-PHC) contamination is hindered by the recalcitrance of pollutants and the disruption of soil microbial networks. The efficacy of biochar amendments relies on balancing two opposing functions of contaminant adsorption and microbial biostimulation. Here, we propose a microecological threshold framework to resolve this trade-off. By investigating biochar application rates (0 %-5.5 %), we identified a critical threshold at approximately 1 %, where weak stimulation optimally balanced substrate bioavailability with microbial activation. This condition sustained high microbial diversity and fostered cooperative, circular network architectures, resulting in a 50.86 %-83.60 % enhancement in A-PHC degradation compared to controls. Conversely, supra-threshold dosages, while initially stimulating activity, triggered a collapse in diversity and the formation of competitive networks, ultimately stalling degradation. Community assembly analysis revealed a shift from deterministic filtering to stochastic, interaction-driven processes under threshold-optimized conditions. Spectroscopic evidence confirmed that enhanced biodegradation was driven by active microbial transformation of dissolved organic matter, distinct from the abiotic adsorption dominance observed at higher dosages. These findings validate the microecological threshold as a critical parameter for precision bioremediation, shifting the focus from simple pollutant reduction to the reconstruction of functional ecosystem networks. - Source: PubMed
Publication date: 2025/11/21
Wang GuoliangLi RuixiangZhang XiaolinWang WenhanKang JiaqiStom DevardLi TianZhou QixingLi NanWang Xin - The aim of this study was to investigate the mediating role of immune cells in the relationship between plasma proteins and the risk of major depressive disorder (MDD). Using a two-step, two-sample Mendelian randomization (MR) approach, we systematically assessed whether immune cells mediate the causal effects of plasma proteins on MDD. We found that eleven plasma proteins (TRABD, CACNB4, EDA, SAR1A, GLRX, COTL1, STOM, CRP, FGF22, and EDA2R) were positively associated with MDD risk, while one protein (SPTLC1) exhibited a negative association. Additionally, seven immune cell phenotypes-including CD14 on CD33dim HLA DR + CD11b + , memory B cells (% of B cells), IgD⁻ CD24⁻ % B cells, CD20 on B cells, CD27 on IgD⁺ CD24⁺, CD27 on IgD⁻ CD38dim, and CD62L on CD62L⁺ DCs-showed potential causal effects on MDD. Further mediation analysis revealed that three immune cell types mediated the effects of four plasma proteins on MDD: CD27 on IgD⁺ CD24⁺ cells mediated the effects of both COTL1 and RNF122 (mediation proportions: 5.13% and 4.50%, respectively); IgD⁻ CD24⁻ % B cells mediated the effect of EDA (12.1%); and CD62L on CD62L⁺ DCs mediated the effect of GLRX (-9.46%). The negative mediation proportion suggests a protective pathway. Sensitivity analyses supported the robustness of these findings.These results provide novel insights into immune-mediated mechanisms linking plasma proteins to MDD and may inform future research into targeted immunotherapeutic strategies. - Source: PubMed
Publication date: 2025/11/13
Jia RuolingNie MingkunWang XunYang Yang