Ask about this productRelated genes to: PCDGF antibody
- Gene:
- GRN NIH gene
- Name:
- granulin precursor
- Previous symbol:
- -
- Synonyms:
- PCDGF, PGRN, CLN11
- Chromosome:
- 17q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-30
- Date modifiied:
- 2019-04-23
Related products to: PCDGF antibody
Related articles to: PCDGF antibody
- Progranulin (PGRN), a glycosylated protein, is expressed in most tissues, including bones, and its level is elevated in the serum and joints of individuals with inflammatory bone loss disorders such as rheumatoid arthritis (RA). Previously, using global and macrophage-specific deletion mice, we demonstrated that loss of PGRN protects against age-related bone loss selectively in females, suggesting a sex-dependent role for macrophage-derived PGRN in skeletal homeostasis. Here, we investigated the role of PGRN in the regulation of macrophage-mediated inflammation and bone formation. Immune-phenotyping revealed that vs. WT mice exhibited higher percentages of Mac2 subsets in both sexes. Transcriptomic analysis of Mac2 vs. Mac2 from WT mice showed reduced expressed expression of and at baseline in both sexes. Further, vs. WT M-CSF-dependent macrophages (BMMs) revealed decreased expression of and following LPS challenge in vivo in both sexes. Consistent with this, mice displayed markedly reduced IL-1β production in serum and paw joints, and attenuated bone erosion in the STA-induced RA model, indicating altered NLRP3 inflammasome signaling in mice. Notably, PGRN deficiency enhances the osteoanabolic capacity of macrophages: female BMMs potentiated osteogenic differentiation of mesenchymal stem cells, and , females exhibited higher trabecular bone formation in response to intermittent PTH. Collectively, PGRN deficiency in BMMs is negatively associated with expression and IL-1β production and causes reduced inflammation and bone erosion in mice subjected to STA-induced RA. Furthermore, PGRN limits the bone-anabolic action of PTH in a female sex-specific manner. - Source: PubMed
Publication date: 2026/05/06
Nissenson RobertPiprode VikrantWang LipingKohli GursimarNicolae PetronelaWang YueWang ChunMbalaviele GabrielNakamura Mary - Neuropathic pain (NP) is a chronic pain condition caused by injury to the nervous system. Although alternative splicing dysregulation has been implicated in NP, the contribution of RNA-binding proteins (RBPs) to this process remains unclear. - Source: PubMed
Publication date: 2026/05/15
Zhou JunJia YifanSong WeiZhang YingXia Zhongyuan - Single-cell RNA sequencing (scRNA-seq) enables high-resolution studies of gene regulation, capturing gene expression at the individual cell level. We previously developed scRAPID, a computational pipeline for predicting protein-RNA interactions and identifying hub RNA-binding proteins (RBP) and RNAs through the integration of gene regulatory network (GRNs) inference from scRNA-seq data and catRAPID predictions. To make this tool accessible to a broader audience, we introduce scRAPID-web, a user-friendly web server for the prediction of RBP-RNA and RBP-RBP interactions from scRNA-seq data across eight model organisms. - Source: PubMed
Publication date: 2026/05/14
Fiorentino JonathanArmaos AlexandrosMontrone ChiaraColantoni AlessioTartaglia Gian Gaetano - Circadian rhythms are mainly generated by a gene regulatory network (GRN) constituted by transcription factors (TFs). Comparisons between plant and mammalian circadian clock GRNs suggest conservation of the network architecture rather than its components. Therefore, a rhythm-generating capacity is not restricted to canonical circadian clock GRNs. Here, we showed that although the circadian clock GRN was arrhythmic, circadian rhythms were maintained in refrigerated postharvest strawberries. Through systematic dual-luciferase assays and network analysis, we discovered a noncanonical GRN pillared by five uncharacterized TFs. We developed a heterologous reconstitution system and demonstrated the rhythm-generating ability of this GRN. Subsequent systematic evolution of ligands by exponential enrichment followed by high-throughput sequencing (SELEX-seq), electrophoretic mobility shift assay (EMSA), and DNA affinity purification (DAP)-qPCR analyses suggested that this GRN was responsible for the circadian rhythms of downstream genes. Fruit-specific perturbation of this GRN led to enhanced susceptibility to Botrytis cinerea. Collectively, our study identified a noncanonical quasi-circadian GRN, realized the heterologous reconstitution of eukaryotic circadian GRNs, and demonstrated its function in immune regulation. - Source: PubMed
Publication date: 2026/05/12
Wang ShuyuSu YanningXu YufengWang ZhaoqiYao LiWu YueHu YanfeiLiu HongyeKou JunrongLi PeikaiWang XingweiLi YuxinZhang LinDeng JunyiWang LijunHuang YunWei JinfengZhou JunhuiYou XiongZhou MianHe HangWang Wei - Computed coronary tomography angiography (CCTA) is an important diagnostic tool in patients with suspected acute coronary syndromes (ACS). We present a case of vasculitis and coronary involvement, in which CCTA provided critical insights for both diagnosis and management. - Source: PubMed
Publication date: 2026/05/11
Sagris MariosWinkler ManuelChristiaens NoorGéraud CyrillKorosoglou Grigorios