Ask about this productRelated genes to: PCDGF antibody
- Gene:
- GRN NIH gene
- Name:
- granulin precursor
- Previous symbol:
- -
- Synonyms:
- PCDGF, PGRN, CLN11
- Chromosome:
- 17q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-30
- Date modifiied:
- 2019-04-23
Related products to: PCDGF antibody
Related articles to: PCDGF antibody
- Frontotemporal Dementia is an umbrella term for several neurodegenerative disorders that have a similar presentation pattern, which is accompanied by neural damage and brain tissue loss in the frontal and temporal regions. Recent studies have observed that the heterogeneity of Frontotemporal Dementia (FTD) is reflected in clinical features, genetics, and molecular perspectives. Specifically, the major forms of pathology in FTD are linked to abnormal protein accumulation, which includes tau, TAR DNA-binding protein 43 (TDP-43), and fused in sarcoma (FUS). Moreover, genetic research on FTD has identified vital mutations in MAPT (Microtubule-associated protein Tau), GRN (Progranulin Gene), and C9ORF72 genes (Chromosome 9 open reading frame genes). Recent developments in neuroimaging, biomarker levels in body fluids, and molecular profiling have increased diagnostic precision, enabling earlier detection of disease subtypes. Neurofilament light chain (NfL), progranulin, and several other biomarkers, together with novel neuroimaging approaches, are currently being applied for disease classification, prognosis, and disease treatment monitoring. These developments have accelerated the application of precision medicine for FTD, including antisense oligonucleotides, progranulin-restorative drugs, tau-specific therapies, and gene therapy. Despite advances in elucidating the biology of FTD, no disease-modifying therapies have yet been developed, and treatments remain symptomatic until now. Undoubtedly, there are many challenges when taking into account variable presentation, overlapping pathologies, and the lack of robust biomarkers. The aim of this paper is to provide an in-depth analysis of the epidemiology, clinical features, molecular pathologies, biomarkers, and potential therapeutic approaches concerning FTD, with a particular emphasis on the growing role of precision medicine. Omics technologies, biomarker- based patient stratification, and hypothesis-driven clinical trials are undoubtedly essential steps towards personalized therapy for FTD. - Source: PubMed
Publication date: 2026/08/30
Raj KaushikKumari NandaniBharti PragyaKumar RanjeetKumar Dharmendra - Evolvability refers to the capacity of biological systems to generate heritable and adaptive phenotypic variation. Theoretical work has identified general principles linking gene regulatory network (GRN) architecture, including modularity and connectivity, to the generation of such variation, whereas empirical studies have uncovered its molecular basis in specific systems. Despite these advances, the two approaches have largely developed in parallel, with direct tests of theoretically derived hypotheses remaining rare. Recent advances in single-cell omics techniques, GRN inference, and experimental perturbation methods now provide opportunities for a closer link between theory and empirical research on evolvability. Here, we synthesise the main advances on this topic and outline potentially fruitful avenues for investigating how network structure and developmental dynamics shape evolvability across systems. - Source: PubMed
Publication date: 2026/09/07
Jorritsma AlgerKiggen AaronVan Belleghem Stevenvan den Berg Pieter - Gustatory systems drive critical survival behaviors such as feeding, foraging, and social interactions. However, gustation remains one of the least mapped sensory modalities at the connectome level. Here, we present the first complete wiring diagram of the male Drosophila adult gustatory system, comprehensively reconstructing gustatory receptor neurons (GRNs) from peripheral organs in a contiguous electron microscopy volume spanning brain, cervical connective, and ventral nerve cord. Integrating this with existing datasets, we generated a pan-central nervous system (CNS), cross-sex connectome that reveals GRN diversity through connectivity-based clustering, molecular identity mapping, and sexual dimorphism analysis. We mapped all feeding motor neurons and traced complete sensory-to-motor pathways to feeding, foraging, endocrine, and social behavior circuits. The emerging circuit architectures reveal distinct circuits for nutrient assessment, motor control, neuroendocrine regulation, and courtship. This work defines the gustatory system's organization at synaptic resolution and provides a framework for understanding how internal states modulate sensory-driven decisions across behavioral contexts. - Source: PubMed
Tastekin Ibrahimde Haan Vicente InêsBeresford Rory JMorris Billy JBeckett IsabellaSchlegel PhilippGkantia Marina Marin Elizabeth CCosta MartaJefferis Gregory S X ERibeiro Carlos - Given the distinct pathogenic mechanisms of early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD), identifying disease-specific therapeutic targets for each subtype is particularly critical. - Source: PubMed
Publication date: 2026/03/04
Chen LinSun HongxuFang Ming-JuanCheng NanXu Yin - Immunotherapy resistance remains a major clinical challenge in advanced microsatellite instability-high (MSI-H) colorectal cancer (CRC), and the underlying gene regulatory networks (GRNs) distinguishing PD-1-resistant from PD-1-sensitive tumors are poorly defined. - Source: PubMed
Publication date: 2026/02/25
Liang RuiZhang YangXing LuWang WenbinLi YunfengShen TaoCai XinyiYang ZhaoyuLi JibiaoYang XiaotaoZhang XuanWu Tao