Ask about this productRelated genes to: LPAR3 antibody
- Gene:
- LPAR3 NIH gene
- Name:
- lysophosphatidic acid receptor 3
- Previous symbol:
- EDG7
- Synonyms:
- LP-A3, Edg-7, RP4-678I3, HOFNH30, LPA3
- Chromosome:
- 1p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-01-02
- Date modifiied:
- 2014-11-19
Related products to: LPAR3 antibody
Related articles to: LPAR3 antibody
- Despite significant advancements in ARTs, nearly 70% of embryo transfers fail, with implantation failure being the primary cause. Proper embryo implantation requires coordinated communication between the blastocyst and a receptive endometrium, particularly through stromal cell decidualization. A thin or poorly responsive endometrium is associated with reduced implantation and pregnancy rates. However, effective treatments for enhancing endometrial receptivity remain limited. Platelet-rich plasma (PRP), which contains growth factors and bioactive molecules, has recently emerged as a promising agent for improving endometrial thickness and fertility outcomes in patients experiencing repeated implantation failure. However, the underlying molecular mechanisms remain unclear. In the present study, we investigated the effects of PRP on the uterus using a pseudopregnant mouse model that mimics the hormonal and endometrial conditions of early pregnancy. We found that intrauterine PRP injection induced decidual-like responses even in the absence of an embryo. Lipidomic analysis revealed that PRP contains high levels of lysophosphatidic acid (LPA), a signaling lipid that promotes decidualization via the G protein-coupled receptor Lpar3. In agreement with the lipidomic data, the injection of pure LPA also evoked decidual reactions. Notably, PRP-induced decidualization was abolished in Lpar3-deficient mice. These findings indicate that PRP exerts its pro-decidual effects through the LPA-Lpar3 axis and provide mechanistic insights into its therapeutic potential for improving implantation success. - Source: PubMed
Publication date: 2026/04/24
Kaku TetsuakiAikawa ShizuKano KuniyukiOkudaira MichiyoFukui YamatoIshizawa ChihiroAoki JunkenHirota Yasushi - Syrup (ABS) is a commonly used traditional Chinese patent medicine for insomnia and amnesia, and also has the potential to anti-aging but lacks scientific support of pharmacological and mechanism research. This study aims to investigate the anti-aging effect of ABS and its underlying mechanism. - Source: PubMed
Publication date: 2026/03/10
Sun YuanfangXia QiWu RuolanLiu GangWang YongkuanYan ShikaiJin HuiziZhang XiuyunXiao XueLi Shasha - In the tumor microenvironment, hypoxia and stromal interactions contribute to enhanced malignant behavior in cancer cells. This study aimed to assess whether pancreatic cancer cells with higher malignancy display stronger responses to hypoxia and stromal cells than their less malignant parental cells, and evaluated the underlying mechanisms, focusing on lysophosphatidic acid (LPA) receptor signaling linked to the acquisition of malignant traits. Highly invasive PANC-M10 cells, derived from the parental pancreatic cancer PANC-1 cells, were cultured at 1% O to mimic hypoxic conditions and co-cultured with lymphatic endothelial SVEC4-10 cells. Exposure to 1% O increased and expression in PANC-M10 cells. Although cell proliferation in response to LPA treatment in 1% O culture also increased in PANC-1 cells, the increase was more pronounced in PANC-M10 cells. PANC-M10 cells displayed markedly elevated invasive activity in 1% O compared with PANC-1 cells. This hypoxia-induced invasion was reduced by AM966 (LPA antagonist) and GRI-977,143 (LPA agonist), while (2 S)-OMPT (LPA agonist) further enhanced invasive capacity, indicating distinct receptor-dependent functions. Co-culture with SVEC4-10 cells at 1% O amplified the invasive behavior of PANC-M10 cells beyond that observed under monoculture. In addition, the supernatant collected from PANC-M10 cells maintained at 1% O more effectively stimulated SVEC4-10 tube formation than the supernatant from PANC-1 cells. These findings demonstrate that highly invasive pancreatic cancer cells undergo hypoxia-driven crosstalk with lymphatic endothelial cells, promoting tumor progression through LPA receptor-mediated signaling pathways. - Source: PubMed
Publication date: 2026/03/14
Nagano ShionTakai MiwaYashiro NarumiShimomura NanamiTamura MoemiKusumoto YukaYamamoto MaoTsujiuchi Toshifumi - Anxiety is an aggravating comorbidity of many psychiatric disorders that is often underdiagnosed and undertreated, and little is known on the mechanisms underlying its regulation. Here, we find that serum LPA16:0 abundance increases with trait anxiety in both humans and mice; while high LPA16:0 levels are sufficient to reduce the in vitro proliferation of adult hippocampal neural stem/progenitor cells. In humans, the main LPA receptor LPA, bears single nucleotide polymorphism variants associated with anxiety. In mice, LPA16:0 decreases hippocampal neurogenesis and stress resilience, whereas LPA antagonism or the reduction of platelets, the main source of circulating LPA16:0, increases adult neurogenesis and resilience to acute stress. Conditional knockdown of LPA₁ receptor in neural stem cells is sufficient to enhance cell proliferation in the dentate gyrus. Finally, the inhibition of adult neurogenesis abolishes the beneficial effect of LPA antagonism on resilience against both acute and chronic stress. Together, these findings identify circulating LPA16:0 as a biomarker of trait anxiety and LPA16:0-LPA signaling as a regulation mechanism of mood-related behavior through the decrease of adult neurogenesis. - Source: PubMed
Publication date: 2026/02/06
Larrieu ThomasGrieco FabioCarron CharlineVilademunt MartaWeber CrystalGinggen KyllianDelacrétaz AurélieGallart-Ayala HectorTsuda Mumeko CCameron Heather AEap Chin BIvanisevic JulijanaMagistretti PierreSalta EvgeniaTosoni GiorgiaAyyildiz DilaraTelley LudovicDayer AlexandrePiguet CamilleToni Nicolas - In solid tumors, cancer cells adapt to hypoxic and nutrient deprived environments to support malignant progression. This study examined whether hypoxic and low glucose conditions enhance malignant behaviors more strongly in highly migratory MG63-R10 cells, which are derived from osteosarcoma MG-63 cells, compared to parental MG-63 cells, and further investigated whether lysophosphatidic acid (LPA) receptor signaling regulates this adaptation. - Source: PubMed
Publication date: 2025/10/13
Taniguchi AnriTamura MoemiYamamoto MaoYashiro NarumiKusumoto YukaNagano ShionShimomura NanamiTakai MiwaTsujiuchi Toshifumi