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- Immune evasion by Mycobacterium tuberculosis (Mtb) complicates tuberculosis (TB) therapy. Ferroptosis, an iron-dependent form of regulated cell death, is increasingly recognized as a critical process in host-pathogen interactions. We aimed to define the role of poly(C)-binding protein 1 (PCBP1) in macrophage ferroptosis during Mtb infection and to develop a targeted RNA activation (RNAa) nanotherapy to exploit this pathway. - Source: PubMed
Publication date: 2026/05/21
Huang Huan-ShaoChi Jia-XinWang Jia-JunXiao Le-YaoChen LanLai Shi-YingLiu Wan-YiYang FengLiao Kang-ShengPi JiangCong Yan-GuangShao Yi-MingXu Jun-Fa - Fibrosis represents a complex pathological process that culminates in organ damage and failure. Cataract, specifically anterior subcapsular cataract (ASC) and posterior capsular opacity (PCO), is a common manifestation of ocular fibrosis, primarily driven by the epithelial mesenchymal transition (EMT) of lens epithelial cells (LECs). Tripartite motif containing 25 (TRIM25), an E3 ubiquitin ligase and member of the TRIM protein family, plays a pivotal role in various biological processes including protein homeostasis, signaling pathways, immune responses, and cell growth. This study aims to elucidate the role of TRIM25 in LECs EMT and its underlying molecular mechanisms, thereby identifying a novel therapeutic target for the prevention and treatment of fibrotic cataracts. - Source: PubMed
Publication date: 2026/05/15
Liu YifanHuang YihanChen AnlinHan LeiBian LiXu XuanLi Yue - Colorectal cancer (CRC) remains a major cause of cancer-related death, and resistance to chemotherapy and radiotherapy continues to limit durable disease control. Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, has therefore emerged as a potential therapeutic strategy. However, models focused solely on glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11) do not fully explain why CRC cells differ in their sensitivity to ferroptosis. In this review, we examine how ferroptosis in CRC is shaped by iron trafficking and selenium-dependent antioxidant defense. We first discuss the poly(rC)-binding proteins 1 and 2 (PCBP1/2)-nuclear receptor coactivator 4 (NCOA4) axis, which regulates iron storage, trafficking, and ferritinophagy. We then review the AlkB homolog 8 (ALKBH8)-directed selenoprotein network, which supports the detoxification of lipid peroxides and maintenance of redox homeostasis. We next consider how these two systems intersect and how their interplay influences ferroptosis sensitivity. We also discuss why concurrent disruption of iron handling and selenium-dependent defense mechanisms may enhance therapeutic efficacy. Finally, we outline potential clinical applications, including combination strategies and biomarker development. - Source: PubMed
Publication date: 2026/04/29
Tao FulinHe MenghuiDai Yong - Immunotherapies have been widely applied to the treatment of hepatocellular carcinoma (HCC), but to date only a minority of patients exhibit dramatic responses. Tumor-associated macrophages (TAMs) are vital components in the tumor microenvironment and are involved in HCC progression. Herein, we confirm the upregulation of PCBP1 expression in TAMs correlates with poor prognosis in HCC patients. The loss of PCBP1 in TAMs promotes M1 like macrophages polarization and suppresses the migration capability of HCC cells in vitro. Additionally, overexpression of PCBP1 increases M2 macrophage infiltration and promotes tumor growth in vivo. Mechanistically, PCBP1 negatively regulates autophagy flux induction in TAMs to hinder STAT6 degradation from autophagy pathway, thereby facilitating M2-like macrophage phenotype and HCC malignant progression. Collectively, our findings describe the role of PCBP1 in orchestrating TAMs polarization and suggest that blocking PCBP1 is an effective approach in combating the cancerous advancement of HCC. - Source: PubMed
Publication date: 2026/05/10
Luo YueZhang XinyuYang HaoyiYao YuxinWu HaoZhang ZhuYe DongjiePan BanglunWang XiaoqianTang Nanhong - Colorectal cancer (CRC) remains a leading cause of cancer-related death worldwide. Primary sclerosing cholangitis (PSC) increases the risk of CRC, but the biological link is not well understood. Changes in the gut-liver axis, including gut microbiota and microbial metabolites, may contribute to CRC development in PSC. - Source: PubMed
Publication date: 2026/04/24
He ZhaobinSu WeiWang ZhiqiangWang XiaoMa XiaoguangZhao Rui