Ask about this productRelated genes to: HIST1H4E antibody
- Gene:
- HIST1H4E NIH gene
- Name:
- histone cluster 1 H4 family member e
- Previous symbol:
- H4FJ
- Synonyms:
- H4/j
- Chromosome:
- 6p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-07
- Date modifiied:
- 2016-08-15
Related products to: HIST1H4E antibody
Related articles to: HIST1H4E antibody
- Bladder cancer (BC) poses a significant global health and economic burden due to its high recurrence rates, progression risks, and the need for lifelong surveillance. Despite advances in diagnosis and treatment, reliable molecular biomarkers for prognosis and therapeutic targeting remain limited. In this study, we used an integrative bioinformatics approach to identify key dysregulated nuclear genes in BC, focusing on histone variants because of their essential role in chromatin organization and gene regulation. Using RNA-seq data, we performed a quality assessment, aligned reads with STAR, and conducted differential expression analysis using DESeq2. A unique gene expression pattern was seen between the cancer and control groups. From the DEGs, nuclear genes were curated using the NCBI Gene database and analysed their network topology via STRING and Cytoscape. MCODE found the complex cluster, and CytoHubba identified key hub genes, notably histone genes HIST1H3D (H3C4), HIST1H4E (H4C5), and HIST1H4B (H4C2). Functional enrichment via clusterProfiler highlighted roles in chromatin assembly, nucleosome organization, and centromeric dynamics. Notably, pathway analysis revealed links to systemic lupus erythematosus (SLE), neutrophil extracellular trap formation, and transcriptional misregulation, suggesting immunomodulatory roles. Kaplan-Meier survival analysis of patient cohorts using the KM-plotter tool revealed that higher expression of HIST1H4E and HIST1H4B was associated with improved survival outcomes. These findings emphasize the epigenetic and immunological roles of nuclear histone genes in BC progression and lay the groundwork for future translational research aimed at diagnostic and therapeutic advancements. - Source: PubMed
Publication date: 2026/03/25
Elavarasu Santhosh MudipalliAsheem InshaM NihlaS Udhaya KumarMagesh RK SasikumarC George Priya Doss - To investigate whether cuproptosis-related genes contribute to coronary artery disease (CAD) pathogenesis and to develop a robust, blood-based diagnostic model. - Source: PubMed
Publication date: 2025/11/07
Li JiaLei KaiboHu PingZhu ZhanweiWang LinTang Can-ELuo Fanyan - Mendelian randomization (MR) has been used to identify drug targets in many conditions. Height is a classic complex trait affected by genetic and early-life environmental factors. No systematic screening has been conducted to identify drugs that interact with height. We investigated the causal relationship between genes and height, and systematically screened for interactive drugs that may promote or delay growth. - Source: PubMed
Publication date: 2024/11/26
Xi LiCheng RuoqianZhang MiaoyingPei ZhouYe JiangfengZhao Zhuhui - Both and evidence has supported a key role of myeloid cells in immune suppression in melanoma and in promoting melanocytic metastases. Some single-nucleotide polymorphisms (SNPs) have been shown to predict cutaneous melanoma-specific survival (CMSS), but the association between genetic variation in myeloid cell-related genes and cutaneous melanoma (CM) patient survival remains unknown. - Source: PubMed
Publication date: 2021/06/15
He YuanminLiu HongliangLuo ShengAmos Christopher ILee Jeffrey EYang KemingQureshi Abrar AHan JialiWei Qingyi - The purpose of this work was to extract key players such as mRNAs and long non-coding RNA (lncRNAs) in the etiopathogenesis of osteosarcoma (OS). The sequencing analyses (mRNAs and lncRNAs) of OS were conducted followed by differentially expressed mRNAs and lncRNAs (DEmRNAs and DElncRNAs) identification between U-2OS cells with has-miR-590-5p overexpression and negative control cells. Following this, the co-expression and functional enrichment analyses of DEmRNAs and DElncRNAs were carried out. Also, the miRNAs-DElncRNAs-DEmRNAs regulatory network was constructed with DElncRNAs-miRNAs and DElncRNAs-DEmRNAs pairs after the target gene analysis of miRNA. In addition, the ceRNA-has-miR-590-5p was further extracted based on the has-miR-590-5p-DElncRNAs and DElncRNAs-DEmRNAs interactions. Finally, the results of the bioinformatics analysis was verified by reverse-transcription polymerase chain reaction (RT-PCR). Totally, 980 DEmRNAs (539 up-regulated DEmRNAs and 441 down-regulated DEmRNAs) and 682 DElncRNAs (352 up-regulated DElncRNAs and 330 down-regulated DElncRNAs) were extracted between cells with hsa-miR-590-5p overexpression and normal cells. The functional analyses suggested that up-regulated genes were significantly enriched in several GO terms such as signal transduction and cytokine-cytokine receptor interaction pathway while down-regulated genes (, and ) were associated with calcium ion binding, cell surface function and nucleosome assembly. Additionally, the miRNAs-DEmRNAs-DEmRNAs network represented 220 pairs among 41 miRNAs, 38 DElncRNAs and 61 DEmRNAs. Furthermore, the ceRNA-hsa-miR-590-5p network consisted of 70 interaction pairs including hsa-miR-590-5p--CTB-113D17.1, hsa-miR-590-5p--CTB-113D17.1 and hsa-miR-590-5p--CTB-113D17.1) among hsa-miR-590-5p, 30 DEmRNAs and 4 down-regulated DElncRNAs. Meanwhile, the RT-PCR results incidated that compared with the blank (KB) and negative control (NC) group, the mRNA expression of , , and were significantly descreased in mimics group (P value <0.05). The lncRNA CTB-113D17.1 might implicate with OS development probably via serving as a hsa-miR-590-5p sponge to regulate gene targets ( and 4E), which will facilitate the deep understandings of OS progression. - Source: PubMed
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