Ask about this productRelated genes to: DGKK antibody
- Gene:
- DGKK NIH gene
- Name:
- diacylglycerol kinase kappa
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- Xp11.22
- Locus Type:
- gene with protein product
- Date approved:
- 2005-11-25
- Date modifiied:
- 2016-01-14
Related products to: DGKK antibody
Related articles to: DGKK antibody
- : Emerging evidence suggests that biological sex shapes glioma biology and therapeutic response. : We performed a sex-stratified analysis of CGGA (Chinese Glioma Genome Atlas) RNA sequencing data comparing low-grade glioma (LGG) with high-grade glioma (HGG) and glioblastoma (GBM). Using the 3PodR framework, we integrated differential expression analysis with Gene Set Enrichment Analysis (GSEA), EnrichR, leading-edge analysis, and iLINCS drug repurposing. : These comparisons provide a proxy for biological processes underlying malignant transformation. In LGG vs. HGG, 973 significantly differentially expressed genes (DEGs) were identified in females and 1236 in males, with 15.5% and 33.5% unique to each sex, respectively. In LGG vs. GBM, 2011 DEGs were identified in females and 2537 in males, with 12.6% and 30.7% being unique. Gene-level contrasts included GLI1 upregulation in males and downregulation in females, GCGR upregulation in males, MYOD1 upregulation in females, and HIST1H2BH downregulation in males. Additional top DEGs included PRLHR, DGKK, DNMBP-AS1, HOXA9, CTB-1I21.1, RP11-47I22.1, HPSE2, SAA1, DLK1, H19, PLA2G2A, and PI3. In both sexes, LGG-HGG and LGG-GBM grade comparisons converged on neuronal and synaptic programs, with enrichment of glutamatergic receptor genes and postsynaptic modules, including GRIN2B, GRIN2A, GRIN2C, GRIN1, and CHRNA7. In contrast, collateral pathways diverged by sex: females showed downregulation of mitotic and chromosome-segregation programs, whereas males showed reduction of extracellular matrix and immune-interaction pathways. Perturbagen analysis nominated signature-reversing compounds across sexes, including histone deacetylase inhibitors, Aurora kinase inhibitors, microtubule-targeting agents such as vindesine, and multi-kinase inhibitors targeting VEGFR, PDGFR, FLT3, PI3K, and MTOR. : Glioma grade comparisons reveal a shared neuronal-synaptic program accompanied by sex-specific transcriptional remodeling. These findings support sex-aware therapeutic strategies that pair modulation of neuron-glioma coupling with chromatin- or receptor tyrosine kinase/angiogenic-targeted agents, and they nominate biomarkers such as GLI1, MYOD1, GCGR, PRLHR, and HIST1H2BH for near-term validation. - Source: PubMed
Publication date: 2025/12/24
Rami Reddy Madhu Vishnu Sankar ReddyWood Jacob FNorris JordanBecker KathrynMurphy Shawn CDoddi SishirImami AliRyan V William GNguyen JenniferSchroeder JasonEisenmann KathrynMcCullumsmith Robert E - To reveal the molecular basis of knee osteoarthritis (KOA) with Yang deficiency and blood stasis syndrome by analyzing the gene expression profiles in synovial fluid and blood of KOA patients with this syndrome. - Source: PubMed
Hua Hao-TianZhang Zhong-YiJin Zhao-KaiLou Peng-QiangMeng ZhuoZhang An-QiZhang YangTong Pei-Jian - To explore the gut microbiota and proteomic characteristics of hypothyroidism in the first half of pregnancy (referred to as hypothyroidism in the first half of pregnancy) and its association with Th (T helper cells, Th)1/Th2 balance using metagenomics combined with proteomics. - Source: PubMed
Publication date: 2025/05/15
Zhang ChenchenXu YajuanZhang MiaoLi JingjingSun ZongzongWang YixinLin Pengkun - X-chromosome variants contribute significantly to hypospadias risk but have not been fully elucidated in the Chinese population. Here we aim to assess how X-chromosome variants contribute to hypospadias susceptibility in the Chinese population. - Source: PubMed
Publication date: 2025/05/07
Liu YanqingLi BinyaoDeng FumingZhao XinyingLiu ZhihaiZhao JingluFu WenZhang YanZuo Xiaoyu - - Source: PubMed
Publication date: 2024/10/28
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