Ask about this productRelated genes to: CREB3L1 antibody
- Gene:
- CREB3L1 NIH gene
- Name:
- cAMP responsive element binding protein 3 like 1
- Previous symbol:
- -
- Synonyms:
- OASIS
- Chromosome:
- 11p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-09
- Date modifiied:
- 2016-10-05
Related products to: CREB3L1 antibody
Related articles to: CREB3L1 antibody
- Sclerosing epithelioid fibrosarcoma (SEF) is a rare variant of fibrosarcoma that primarily arises in the deep soft tissue of the extremities and trunk. Primary SEF in the visceral organs is rare, and only a few cases have been reported. A 20-year-old man was diagnosed with primary renal SEF metastatic to the lymph nodes and bone, which was managed with open right radical nephrectomy and ongoing chemotherapy. Immunohistochemical staining for MUC-4, vimentin, BCL-2, and EMA was positive in tumor cells. Next-generation sequencing revealed the presence of EWSR-CREB3L1 gene fusions and SMARCB1 rearrangement in exon 6. - Source: PubMed
Publication date: 2025/12/31
Alslimah FaislMoazin MaherAlshehri AbdulrahmanAlharbi YasserHowaidi AliAlqahtani SaifAlmalki Salman - Lung fibroblasts are key regulators of tissue homeostasis and extracellular matrix (ECM) remodeling, and their aberrant activation drives the progressive parenchymal scarring characteristic of idiopathic pulmonary fibrosis (IPF), a fatal disease with limited therapeutic options. Despite their central pathogenic role, lung fibroblasts are difficult to isolate due to their embedded position within the ECM, and standard in vitro culture conditions may lead to the loss of their native functional and transcriptional characteristics, hampering the study of fibroblast behavior in disease. The transcriptional heterogeneity of lung fibroblast subtypes and the extent to which culture-induced alterations diverge from native tissue signatures remain poorly understood. Here, we integrated single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics of lung tissue from IPF patients and age-matched healthy donors with transcriptomic profiling of cultured fibroblasts collected at passages 1 and 6 after isolation using three optimized protocols: whole lung cell suspension (WLCS), negative fraction enrichment, and outgrowth. Tissue-based analysis identified six transcriptionally distinct mesenchymal subtypes: alveolar, adventitial, inflammatory, peribronchial, CTHRC1+ and smooth muscle cell (SMC). The fibroblast subtype CTHRC1+ represented the most transcriptionally activated pro-fibrotic subtype, showing the greatest upregulation of ECM biosynthesis genes, a prominent role in intercellular communication, and preferential enrichment within fibroblastic foci in IPF lung tissue. Pseudotime trajectory analysis supported a directional transcriptional continuum from alveolar and inflammatory fibroblasts toward the CTHRC1+ state, driven by coordinated activation of pro-fibrotic transcription factors, including RUNX2, CREB3L1, and SCX. In vitro culture progressively reshaped fibroblast transcriptional identity relative to native tissue, with increased collagen and matrix metalloproteinase (MMP) expression during passaging, loss of distinct CTHRC1+ fibroblasts, and gain of alveolar fibroblasts displaying pro-fibrotic activation across all isolation protocols. These findings provide a high-resolution transcriptional map of lung fibroblast heterogeneity in IPF and highlight critical limitations of standard in vitro culture systems for recapitulating native fibroblast diversity, with important implications for the development and evaluation of fibroblast-targeted therapeutic strategies in IPF. - Source: PubMed
Publication date: 2026/04/10
Vanegas-Avendano N DChen HWellmerling JRodriguez-Lopez JGhobashi APeters VSen CReader B FShilo KGomperts BMa QMora A LTschumperlin D JRojas M - - Source: PubMed
Publication date: 2026/04/06
Li YuhuiChen RongxiMo HuiWu QiLi ZhunHe SaiqiZhou AijunYu ShuhuiDuan ChaohuiNi WenLi Jianming - - Source: PubMed
Publication date: 2026/04/03
Mellor PaulSmith Shari EKendall StephanieKyrylenko LiliiaMonzer AlissarSaxena AnuragGoubran FarahAnderson Deborah H - Analyzing colorectal cancer (CRC) tumor heterogeneity reveals key clues for identifying new therapeutic targets. This study systematically investigates cellular heterogeneity and potential biomarkers in CRC through the integration of single-cell and bulk transcriptomic data. By integrating single-cell and bulk transcriptomic data obtained from databases utilizing Scissor and CIBERSORTx, as well as survival analysis, goblet cells displayed notable distinctions across CRC and normal groups and meaningful links to CRC patient prognosis, leading to their recognition as a key cell subtype. Afterthat, CAPN9, AGR3, KLK1, ERN2, and CREB3L1 were identified as biomarkers, which showed a noteworthy downward trend in the CRC samples. These biomarkers were functionally involved in multiple biological pathways implicated in CRC, such as Retinol metabolism, Cell cycle, and Neuroactive ligand-receptor interaction. Moreover, molecular docking revealed that Permethrin demonstrated high binding affinity toward CAPN9, exhibiting a binding energy of -7.2 kcal/mol. This study showed that goblet cells played a key role in CRC progression. These findings support the understanding of CRC pathogenesis and the development of new therapies. The generated matrix provides a high-precision tool for the cell landscape research of CRC. - Source: PubMed
Publication date: 2026/03/24
Huang ShuzhenXiao ZhengZhao RunkaiLi ZijianLing JunyiDeng GuangceWang YuehuaZhao QiyueGao HanLi Kaishu