Ask about this productRelated genes to: CD11d antibody
- Gene:
- ITGAD NIH gene
- Name:
- integrin subunit alpha D
- Previous symbol:
- -
- Synonyms:
- CD11d, ADB2
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-06-09
- Date modifiied:
- 2016-01-15
Related products to: CD11d antibody
Related articles to: CD11d antibody
- In recent years, except for the well-known heart failure with reduced ejection fraction (HFrEF), the incidence of heart failure with preserved ejection fraction (HFpEF) and heart failure with mildly reduced ejection fraction (HFmrEF) among the classification of heart failure (HF) has been increasing. However, due to their complex mechanisms, current research remains insufficient to address clinical needs. - Source: PubMed
Publication date: 2026/01/29
Zhang LeQuan MinxueZhang Xiao-ChengZhang Shi-YaoChen Jia-FengYu Li-QingFu GuoLi GangWang Ruiying - Benign prostatic hyperplasia (BPH) is a common condition in middle-aged and elderly men. Disrupted circadian rhythms (CRD) can directly influence aging, inflammation, metabolic syndrome, and hormonal changes-all of which are closely linked to BPH. This study aimed to investigate whether CRD accelerates prostatic hyperplasia in rats. Twenty male Sprague-Dawley (SD) rats were divided into two batches. A BPH model was established using mixed slow-release pellets of testosterone (T) and estradiol (E2). CRD was induced by continuous light exposure (Cle), while a 12-hour light/12-hour dark cycle defined the control (Con) group. - Source: PubMed
Publication date: 2025/10/15
Huang XiaoxueTang XiaohuXu YuanzhaoLiu ZhiyanLuo Guangheng - Migraine is a chronic neurovascular disease with unclear pathophysiological mechanisms. In this study, its pathogenic mechanisms were investigated through bioinformatics analysis of migraine-related pathways and key genes. Female Sprague Dawley rats were divided into control and migraine model groups. The control group received saline, while the migraine model group received nitroglycerin (NTG) to induce migraines over four weeks. Migraine-like behaviors were assessed within two hours following the final NTG injection. Genes of hypothalamus were identified using DESeq2. Gene ontology enrichment and KEGG pathway analyses were conducted, followed by the identification of hub genes based on protein interaction networks by using algorithms such as Closeness, Degree, and Maximum Neighborhood Component. Rats with NTG-induced migraine showed increased head scratching and cage climbing and a reduced sucrose preference. Transcriptome analysis revealed 1564 differentially expressed genes, with 1233 upregulated and 331 downregulated. Pathways linked to inflammation, PI3K-Akt signaling, and cytokine-cytokine receptor interactions were found to have enriched expression of several genes. Further protein interaction network analysis identified nine hub genes: , , , , , , , , and . These findings suggest that migraine involves PI3K-Akt signaling and cytokine-cytokine receptor interactions, providing insights into molecular mechanisms and potential therapeutic targets. However, the study was limited by a small sample size and reliance on a single experimental model, which may constrain the clinical applicability of the findings. - Source: PubMed
Publication date: 2025/03/30
Chen Qiao-WenMeng Run-TianKo Chih-Yuan - Systemic lupus erythematosus (SLE) is characterized by the overproduction of autoantibodies, and B cells are considered to be the primary cells involved in the development of SLE. Studies have shown that DNA damage responses play a role in B cell activity in SLE. However, the exact role of DNA damage-induced transcript 3 (DDIT3) in humoral immune response and SLE pathogenesis remains unknown. We observed increased expression of DDIT3 in B cells of SLE patients and this expression was positively correlated with disease activity. In DDIT3-knockout mice, we observed disturbances in B cell development and differentiation, inhibition of B cell activation, and BCR signaling. In addition, DDIT3 deficiency leads to a reduction in T-cell-dependent humoral immune responses. Mechanistically, we found that DDIT3 promotes the transcription and expression of , which enhances PI3K signaling and B cell activation. Finally, we found that DDIT3 deficiency attenuated lupus autoimmunity and reduced germinal center responses. In conclusion, our study reveals for the first time the role of DDIT3 in adaptive immune responses, especially in B cell homeostasis, B cell activation, BCR signaling, and B cell function. These findings provide a new potential target for therapeutic intervention in SLE. - Source: PubMed
Publication date: 2025/03/03
Dai XinYu JialiZhang YunfeiWang ZhimingDai YunyanHu YingWang XiaocuiTian BinbinWu MinhuiChen HaoSong RuigaoMa DanWang Cong-YiYe DaweiZheng ZiliangZhang LiyunLuo JingJing Yukai - The purpose of this study was to identify molecular subtypes and hub genes in fibromyalgia [FM] based on immune-related genes [IRGs]. - Source: PubMed
Zhao WeiWang Pengcheng