Ask about this productRelated genes to: CBP20 antibody
- Gene:
- NCBP2 NIH gene
- Name:
- nuclear cap binding protein subunit 2
- Previous symbol:
- -
- Synonyms:
- NIP1, CBP20, Cbc2
- Chromosome:
- 3q29
- Locus Type:
- gene with protein product
- Date approved:
- 2000-01-17
- Date modifiied:
- 2015-11-09
Related products to: CBP20 antibody
Related articles to: CBP20 antibody
- Cervical cancer is one of the major threats to women's health worldwide. Nuclear Cap Binding Protein 2(NCBP2) plays a significant role in various cancers, and mitophagy, as a cellular homeostasis regulation mechanism, is closely related to tumorigenesis and development. However, the specific mechanisms by which NCBP2 regulates mitophagy in cervical cancer remain unclear. Bioinformatics was used to screen cervical cancer-related genes and mechanisms. The effects of NCBP2 on the viability, migration, and mitochondrial function of cervical cancer cells were investigated using CCK-8, EdU, and Transwell assays. Comprehensive experimental methods, including RT-qPCR and Western blot, were employed to elucidate the potential mechanisms of NCBP2. NCBP2 was found to be significantly upregulated in cervical cancer and promoted the in vitro proliferation, migration, and invasion of cervical cancer cells. Mechanistically, NCBP2 regulated the alternative splicing of KIF23 to facilitate cervical cancer progression. NCBP2 also regulated mitophagy in cervical cancer cells via the KIF23-PGAM5 axis. Moreover, FBXW8 inhibited the overactivation of mitophagy and exerted tumor-suppressive effects by ubiquitinating and degrading NCBP2. This study reveals that NCBP2 regulates alternative splicing and mitophagy to influence cervical cancer progression, providing new potential therapeutic targets and strategies for cervical cancer treatment. - Source: PubMed
Publication date: 2026/03/24
Su YingZhang JuxinWu HenghuiZhang YuZhou Wenlei - RNA-binding proteins play critical roles in RNA processing and are aberrantly expressed in colorectal cancer (CRC). Through comprehensive analysis of multiple gene expression datasets (GSE20916, GSE18105, GSE21510, TCGA-COAD and TCGA-READ), NCBP2 was identified as a potential tumorigenic gene in CRC. NCBP2 expression was significantly elevated in CRC tissues, correlated with tumour invasion and metastasis, and associated with poor patient survival outcomes. Furthermore, overexpression of NCBP2 in CRC cells was shown to increase cell proliferation, migration, and tumour invasion in both in vitro and in vivo models. Mechanistically, the NCBP2 protein stabilised LIPG mRNA via direct binding to the m7G motif in the 5'-cap structure of LIPG mRNA, thereby increasing LIPG expression. Additionally, NCBP2 promoted lipid droplet accumulation in CRC cells in a LIPG-dependent manner. These findings collectively suggest that the NCBP2-LIPG-lipid droplet axis represents a novel mechanism underlying CRC progression and metastasis, providing a promising therapeutic target for CRC treatment. - Source: PubMed
Publication date: 2026/03/24
Liu LiuLu WeiMiao ShengyuanYu YangZhang Xu-BingYe ShouDongWang XiaoxiaoLiu Lin - Cassava production in sub-Saharan Africa is severely impacted by diseases. Most pathogens require interaction with host susceptibility factors to complete their life cycles and cause disease. Targeted DNA methylation is an epigenetic strategy to alter gene expression in plants, and we previously reported that a zinc-finger fused to DMS3 could establish methylation at the promoter of , a bacterial susceptibility gene, and this resulted in decreased disease. Here, we attempt a similar strategy for cassava brown streak disease. This disease is caused by the ipomoviruses CBSV and UCBSV. These viruses belong to the family , which has been shown extensively to require host eIF4E-family proteins to infect plants and cause disease. We previously found that cassava plants with simultaneous knockout mutations in two genes, , resulted in decreased susceptibility to CBSD. Here, we report successful simultaneous targeting of both promoters with methylation using a dCas9-DRMcd-SunTag system. However, in contrast to our previous work with controls indicate that CRISPR interference is occurring in these lines and is sufficient for the reduction of gene expression. Future research will use genetic crosses to segregate away the DNA methylation reagents and, if DNA methylation proves heritable, assess whether methylation alone is sufficient to increase resistance to CBSD. - Source: PubMed
Publication date: 2026/02/06
Lin Zuh-Jyh DanielHernandez Gabriela LStanton Myia KZheng XingguoGilbert Kerrigan BVeley Kira MJensen GregYoder MarisaFeng SuhuaGhoshal BasudevGardiner JasonWang MingJacobsen Steven ECarrington James CBart Rebecca S - The pathogenesis of colorectal cancer is complex and difficult to treat, and there is a risk of metastasis and recurrence. m7G modification as a kind of RNA modification has been widely concerned in the field of tumor. However, there are few research in the field of CRC. This study aims to elucidate the effects of m7G modification on CRC from the perspective of single cell transcriptome and search for potential therapeutic targets. - Source: PubMed
Publication date: 2025/12/17
Hu JieChen ZhihuaMa ChenyangFang YuanLi QuanfaZheng JiebinHe JiannanLin SuyongChen Shaoqin - Unexplained recurrent spontaneous abortion (URSA) poses significant clinical challenges, with immune dysregulation at the maternal-fetal interface implicated in 80% of cases. While RNA modifications like N7-methylguanosine (m7G) are emerging as key regulators of immune pathologies, their role in URSA remains unexplored. - Source: PubMed
Publication date: 2025/12/02
Guo QingWang ShimengSong SujieZhao Xiaoxuan