Ask about this productRelated genes to: ADAR1 antibody
- Gene:
- ADAR NIH gene
- Name:
- adenosine deaminase RNA specific
- Previous symbol:
- IFI4, G1P1
- Synonyms:
- ADAR1
- Chromosome:
- 1q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-12-12
- Date modifiied:
- 2019-04-23
Related products to: ADAR1 antibody
Related articles to: ADAR1 antibody
- Cannabis use during pregnancy or lactation is a key topic in healthcare today. It is recommended that patients abstain from perinatal use and healthcare providers are encouraged to discuss use with patients. However, some perinatal individuals continue to use even once educated about the risks. For them, a nuanced approach to counseling that goes beyond warnings of risks is required to promote health and maintain trust. Harm reduction, which views any reduction in harm as a clinical success, is the best evidence-based practice for these patients. However, the essential elements (core components) of this approach have not yet been identified. This limits the approach's readiness for wider implementation, as it is critical that essential elements are maintained during intervention adaptation and scaling. We used the Consensus on Relevant Elements process to generate an initial list of core components for harm reduction counseling of cannabis using-pregnant and breast-feeding patients. We identified five core components within two domains. Within the domain of provider training, the provider 1) is skilled at facilitating conversation, and 2) is educated about cannabis use. Within the domain of patient-facing work, the provider 3) educates patients about cannabis safety and recommendations, 4) screens for cannabis, and 5) provides a brief harm reduction intervention. Future work to achieve a broader consensus of the core components of this approach should be undertaken to confirm these findings. This work serves as an important first step towards equipping healthcare providers to promote health for perinatal cannabis-using patients. - Source: PubMed
Publication date: 2026/04/13
Albanese Ariana MCramer E RubyFrank Hannah ERogers Brooke G - Pegylated interferon alpha (Peg-IFN-α) has the potential for eradicating hepatitis B surface antigen (HBsAg). The aim of our study is to investigate whether the expression levels of adenosine deaminase acting on RNA 1 (ADAR1), NEDD4-binding protein 1 (N4BP1), proteasome activator complex subunit 1 (PSME1) mRNAs in peripheral blood mononuclear cells (PBMCs) of HBeAg-negative chronic hepatitis B virus (HBV) patients are associated with the response to Peg-IFN-α treatment and HBsAg clearance. - Source: PubMed
Publication date: 2026/04/13
Pang HaoFu XinglinChen LüpingYang ShuhanYang FanQin Bo - - Source: PubMed
Publication date: 2026/04/10
Li XiaolingWang YunguanMu Ping - Adenosine deaminase acting on RNA 1 (ADAR1) regulates mRNA fate and function through adenosine-to-inosine (A-to-I) RNA editing and RNA-binding activities. While its role in innate immunity is established, the broader regulatory functions of ADAR1 in macrophages remain poorly defined. Here, we systematically profiled ADAR1 expression across human immune cells and identified marked enrichment in macrophages, driven by selective usage of an alternative transcription start site during monocyte-to-macrophage differentiation. ADAR1 binds, edits, and modulates key macrophage targets involved in efferocytosis, endocytosis, lysosomal processing, lipid metabolism, and proliferation in an isoform-specific manner. We further demonstrate that ADAR1 levels and activity are dynamically regulated in adipose tissue and liver during the progression of metabolic disease. Linked to this, macrophage-specific ablation of ADAR1 co-cultured in organotypic 3D primary human liver spheroids and exposed to metabolic stress resulted in an exacerbated lipid accumulation phenotype. Finally, we identify a lipid-associated macrophage-specific upregulation of ADAR1 in adipose tissue following weight loss interventions, mechanistically driven by free fatty acids. These findings uncover a previously unrecognized role for ADAR1 in lipid-buffering, scavenging, and proliferative macrophage functions, extending its biological relevance beyond canonical interferon-mediated immunity and establishing ADAR1 as a key regulator of macrophage adaptation in metabolic disease. - Source: PubMed
Fardellas AchilleasBarreby EmelieBrice MadaraNock SebastianRussick JulesVankova AnaEdberg CharlotteRobertsen IdaHertel Jens KStål PerMellgren GunnarKarlsson CeciliaHjelmesaeth Jøran SHagström HannesNäslund ErikLauschke Volker MFernø JohanChen PingMorgantini CeciliaAouadi MyriamBjörkström Niklas K - - Source: PubMed
Publication date: 2026/04/25
Pedde MeredithAdar Sara DJang Dae-GyuFeldman Eva LGoutman Stephen A