Ask about this productRelated genes to: ACTA1 antibody
- Gene:
- ACTA1 NIH gene
- Name:
- actin alpha 1, skeletal muscle
- Previous symbol:
- ACTA
- Synonyms:
- NEM3
- Chromosome:
- 1q42.13
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: ACTA1 antibody
Related articles to: ACTA1 antibody
- Fibromatosis-like metaplastic carcinoma (FLMC) of breast is a rare neoplasm that exhibits distinct low-grade cytomorphology, a tendency for local recurrence and a favorable prognosis. This retrospective study aimed to evaluate the clinicopathological and immunohistochemical features of FLMC and assess its clinical behavior. Six female patients with histologically confirmed FLMC were included. Hematoxylin and eosin-stained slides were reviewed, and immunohistochemistry for keratin AE1/AE3, keratin CAM5.2, keratin 5/6, p63, EMA, ACTA1, desmin, and CD34 was performed. The mean age was 57.3 years, and all patients presented with a painless breast mass. Tumors were firm, unencapsulated, and averaged 4.9 cm in size on gross examination. Microscopically, they showed bland spindle cells in fascicular and storiform patterns with infiltrative borders. All tumors were positive for keratin AE1/AE3, keratin CAM5.2, and p63. EMA was positive in 1/3 tumors, keratin 5/6 in 3/3, ACTA1 in 2/3. All tumors were negative for desmin and CD34. No nodal metastasis was identified. On follow-up, one patient developed bone metastasis after 2 years, while the others remained disease-free 3 years post-surgery. FLMC is a rare low-grade epithelial malignancy that can mimic benign spindle cell lesions, making immunohistochemistry essential for diagnosis. Complete surgical excision with clear margins is curative in most patients. - Source: PubMed
Publication date: 2026/06/06
Naveed HaniaIdress RomanaEhsan MaidhaDin Nasir UdKayani Naila - Skeletal muscle actin forms the core structural component of thin filaments, which interact with thick filaments to generate contractile force. In addition to force production, the character of muscle contraction activity itself is thought to provide mechanical cues that influence synaptic development and maturation. In mouse skeletal muscle there is an early post-natal switch from embryonic forms of actin to the adult isoform, ACTA1, which increases both filament stability and force production. Newborn mice deficient for ACTA1 ( ), although initially able to breath, move and suckle, develop profound muscle weakness and die during the early neonatal period, despite a compensatory, increase in expression of embryonic actins. We took advantage of this to better understand the response of the neuromuscular junction (NMJ) to a disruption in contractility and activity-dependent signaling during development. Morphological analyses of the diaphragm in mice revealed that the patterning and formation of the NMJ proceed normally through postnatal day 5 (P5), the day at which pups begin to die. Short-term synaptic plasticity, assessed as the endplate potential (EPP) response to paired-pulse stimulation, was also unchanged, indicating normal presynaptic release of neurotransmitters. In contrast, electrophysiological recordings demonstrated significantly prolonged rise and decay kinetics of miniature and evoked endplate potentials, indicating altered postsynaptic receptor properties. Consistent with these functional changes, quantitative real-time PCR showed a reduced ratio of ε- to γ-acetylcholine receptor (AChR) subunit mRNA, reflecting a delay in the developmental switch from embryonic γ-containing to adult ε-containing AChRs. Together, these findings indicate that α-skeletal actin is dispensable for early NMJ morphogenesis but is required for timely postsynaptic receptor maturation, demonstrating a critical role for muscle contractile activity in coordinating synaptic development at the NMJ. - Source: PubMed
Publication date: 2026/05/26
Liu YunYe QiaohongLin Weichun - Cardiac hypertrophy plays an important role in organ damage caused by hypertension and may progress into heart failure. This study investigated the function and underlying mechanisms of phosphofurin acidic cluster sorting protein 2 (PACS2) in relation to cardiac hypertrophy. - Source: PubMed
Publication date: 2026/05/14
Shen ZhijieZhang YinzhuangFang Li - Genetic disorders are major causes of morbidity and mortality in neonatal intensive care units (NICUs), yet traditional tests like karyotyping and chromosomal microarray (CMA) often fail to provide a diagnosis, resulting in a "diagnostic odyssey". Trio whole-genome sequencing (WGS) has emerged as a comprehensive tool capable of detecting a wide range of variants beyond protein-coding regions, potentially offering higher diagnostic yields and rapid, actionable results for critical care management. - Source: PubMed
Publication date: 2026/05/15
Kim Hyun HoChang Yun SilPark Woong-YangPark Joonhong - Kampung Unggul Balitbangtan (KUB) chicken is a superior Indonesian native breed with high adaptability, good growth potential, and desirable meat quality. Nutritional strategies such as multienzyme supplementation are increasingly applied to improve productivity and meat quality without altering basal diet composition. This study investigated the effects of dietary multienzyme supplementation, consisting of phytase and protease, on growth performance, carcass characteristics, organ development, meat quality, and muscle-related gene expression in KUB chickens. Sixteen one-day-old male KUB chicks were randomly allocated to four dietary treatments: a control diet without multienzymes and three diets supplemented with phytase (200 mg/kg) combined with protease at 300, 500, or 700 mg/kg of feed. Growth performance parameters were measured up to 45 days of age, followed by carcass evaluation, organ weight analysis, meat quality assessment, and transcriptomic and quantitative real-time PCR analyses of breast muscle tissue. Multienzyme supplementation significantly improved final body weight and feed conversion ratio, particularly during the finisher phase, while reducing feed intake at higher enzyme inclusion levels. Carcass percentage and breast weight were enhanced in multienzyme-treated groups, accompanied by favorable changes in digestive and immune organ development. Meat quality analysis showed increased water-holding capacity, reduced cooking loss, and improved color characteristics, notably higher redness and lower yellowness values. Transcriptomic profiling and gene expression analysis revealed significant modulation of key muscle growth-related genes, including ACTA1, MYBPC1, TGFβ2, IGF2, and MYH9, indicating adaptive transcriptional responses associated with improved nutrient utilization rather than direct structural muscle alterations. In conclusion, dietary supplementation with a combination of phytase and protease effectively enhances growth performance, feed efficiency, carcass traits, and meat quality in KUB chickens while modulating growth-related gene expression. Multienzyme inclusion represents a promising and cost-effective nutritional strategy for improving productivity and meat quality in native chicken production systems. - Source: PubMed
Publication date: 2026/04/15
Ayuti Siti RaniLamid MirniWarsito Sunaryo HadiArif Mohammad Anam AlKim Eun JoongShin SangsuHamid Iwan SahrialMafruchati MaslichahAkmal MuslimKhairullah Aswin Rafif